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Ischemia/Reperfusion: Effect of nor-NOHA on Mycordial Injury
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Ischemia/Reperfusion: Effect of nor-NOHA on Mycordial Injury

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Our data demonstrates the reduction of myocardial infarct size in our most characterized small animal preclinical model. Data set shows selective arginase inhibitor, affects nitric oxide pathway in …

Our data demonstrates the reduction of myocardial infarct size in our most characterized small animal preclinical model. Data set shows selective arginase inhibitor, affects nitric oxide pathway in rats with administered vehicle or nor-NOHA at 15 minutes prior to induction of myocardial ischemia.


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  • 1. Data demonstrating reduction of myocardial infarct size in mostcharacterized small animal preclinical model nor-NOHA - selective arginase inhibitor, affects nitric oxide pathway - rats administered vehicle or nor-NOHA at 15 minutes prior to induction of myocardial ischemia Effect of nor-NOHA on Myocardial Ischemia / Reperfusion Injury in the Rat Ischemic Zone / Area at Risk (%) 45 40 35 30 Vehicle (n=7) 25 20 nor-NOHA 100 mg/kg (n=6) 15 10 5 0