CHANGE IN STRUCTURE OFCHROMOSOMESSY, Claire Darren L.ROPAL, Roravelle N.AAPD-2B
4 TYPES OF CHROMOSOMAL MUTATIONS1.   Deletion2.   Duplication3.   Inversion4.   Translocation
DELETION Is   also called gene deletion, deficiency, or deletion mutation. Is   a mutation (a genetic aberration) in whi...
2 KINDS OF DELETION:1.   Terminal Deletion2.   Intercalary Deletion / Interstitial     Deletion
TERMINAL DELETIONa deletion that occurs towards the end of a chromosome.
INTERCALARY DELETION /INTERSTITIAL DELETIONa deletion that occurs from the interior of a chromosome.
DUPLICATION orchromosomal  duplication or gene  amplification. isany duplication of a  region of DNA that  contains a ge...
4 KINDS OF DUPLICATION1.   Tandem2.   Reverse tandem3.   Displaced homobrachial4.   Displaced heterobrachial
TANDEMThe occurrence of two identical sequences, one following the other, in a chromosome segment.
REVERSE TANDEMis a non-tandem duplication that brings the new copy to a region that is transcribed in the opposite direct...
DISPLACED HOMOBRACHIALThe  repeated segment doesn’t foolow the arc.
DISPLACED HETEROBRACHIALThe  repeated segent is found on the other side of the arc.
INVERSIONis a chromosome rearrangement in which a segment of a chromosome is reversed end to end.
2 KINDS OF INVERSION1.   Paracentric Inversion2.   Pericentric Inversion
PARACENTRIC INVERSIONdo  not include the centromere and both breaks occur in one arm of the chromosome.
PERICENTRIC INVERSIONincludethe centromere and there is a break point in each arm.
TRANSLOCATION isa chromosome  abnormality  caused by  rearrangement of  parts between  nonhomologous  chromosomes
2 KINDS OF TRANSLOCATION1.   Reciprocal2.   Non reciprocal
RECIPROCAL areusually an exchange of material between nonhomologous chromosomes.
NON RECIPROCAL type of rearrangement involves two acrocentric chromosomes that fuse near the centromere region with loss ...
THE END
Change in structure of chromosomes ( sy, claire & ropal, roravelle)
Change in structure of chromosomes ( sy, claire & ropal, roravelle)
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Change in structure of chromosomes ( sy, claire & ropal, roravelle)

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Types of chromosomal mutations ( SY, Claire Darren L. & ROPAL, Roravelle N.)

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Change in structure of chromosomes ( sy, claire & ropal, roravelle)

  1. 1. CHANGE IN STRUCTURE OFCHROMOSOMESSY, Claire Darren L.ROPAL, Roravelle N.AAPD-2B
  2. 2. 4 TYPES OF CHROMOSOMAL MUTATIONS1. Deletion2. Duplication3. Inversion4. Translocation
  3. 3. DELETION Is also called gene deletion, deficiency, or deletion mutation. Is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is missing.
  4. 4. 2 KINDS OF DELETION:1. Terminal Deletion2. Intercalary Deletion / Interstitial Deletion
  5. 5. TERMINAL DELETIONa deletion that occurs towards the end of a chromosome.
  6. 6. INTERCALARY DELETION /INTERSTITIAL DELETIONa deletion that occurs from the interior of a chromosome.
  7. 7. DUPLICATION orchromosomal duplication or gene amplification. isany duplication of a region of DNA that contains a gene.
  8. 8. 4 KINDS OF DUPLICATION1. Tandem2. Reverse tandem3. Displaced homobrachial4. Displaced heterobrachial
  9. 9. TANDEMThe occurrence of two identical sequences, one following the other, in a chromosome segment.
  10. 10. REVERSE TANDEMis a non-tandem duplication that brings the new copy to a region that is transcribed in the opposite direction so that the copy actually produces the same amino acid as the original
  11. 11. DISPLACED HOMOBRACHIALThe repeated segment doesn’t foolow the arc.
  12. 12. DISPLACED HETEROBRACHIALThe repeated segent is found on the other side of the arc.
  13. 13. INVERSIONis a chromosome rearrangement in which a segment of a chromosome is reversed end to end.
  14. 14. 2 KINDS OF INVERSION1. Paracentric Inversion2. Pericentric Inversion
  15. 15. PARACENTRIC INVERSIONdo not include the centromere and both breaks occur in one arm of the chromosome.
  16. 16. PERICENTRIC INVERSIONincludethe centromere and there is a break point in each arm.
  17. 17. TRANSLOCATION isa chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes
  18. 18. 2 KINDS OF TRANSLOCATION1. Reciprocal2. Non reciprocal
  19. 19. RECIPROCAL areusually an exchange of material between nonhomologous chromosomes.
  20. 20. NON RECIPROCAL type of rearrangement involves two acrocentric chromosomes that fuse near the centromere region with loss of the short arms.
  21. 21. THE END
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