Submit Search
Upload
Xianweijing
•
Download as PPT, PDF
•
1 like
•
1,096 views
Ck Loo
Follow
Report
Share
Report
Share
1 of 16
Download now
Recommended
Transit of Venus 2012 Hong Kong Lecture Series Talk 2, by Mr WC Yue, Hong Kong Astronomical Society
Observations of the Annular Solar Eclipse and the Transit of Venus
Observations of the Annular Solar Eclipse and the Transit of Venus
Sze-leung Cheung
中華民國 高中物理教材 99課綱-基礎物理2B-CH4 牛頓運動定律-1 注意：部分動畫無法顯示 參考資料 陈玉芳，物理學史簡明教程 郭奕玲，沈慧君，物理學演義 維基百科 高二物理課本，99課綱 DeltaMOOCx
2019 高三基礎物理-4-5
2019 高三基礎物理-4-5
阿Samn的物理課本
画面剪辑艺术
画面剪辑艺术
fujun
眼睛視力是可以訓練的
眼睛保健
眼睛保健
mogi
摄像布光1
摄像布光1
fujun
4 3光的折射及透鏡
4 3光的折射及透鏡
wu lin syang
測試PPT
望遠鏡2(光軸)
望遠鏡2(光軸)
brian00782002
光的反射與面鏡成像
光的反射與面鏡成像
popoljung
Recommended
Transit of Venus 2012 Hong Kong Lecture Series Talk 2, by Mr WC Yue, Hong Kong Astronomical Society
Observations of the Annular Solar Eclipse and the Transit of Venus
Observations of the Annular Solar Eclipse and the Transit of Venus
Sze-leung Cheung
中華民國 高中物理教材 99課綱-基礎物理2B-CH4 牛頓運動定律-1 注意：部分動畫無法顯示 參考資料 陈玉芳，物理學史簡明教程 郭奕玲，沈慧君，物理學演義 維基百科 高二物理課本，99課綱 DeltaMOOCx
2019 高三基礎物理-4-5
2019 高三基礎物理-4-5
阿Samn的物理課本
画面剪辑艺术
画面剪辑艺术
fujun
眼睛視力是可以訓練的
眼睛保健
眼睛保健
mogi
摄像布光1
摄像布光1
fujun
4 3光的折射及透鏡
4 3光的折射及透鏡
wu lin syang
測試PPT
望遠鏡2(光軸)
望遠鏡2(光軸)
brian00782002
光的反射與面鏡成像
光的反射與面鏡成像
popoljung
Lets.play.basketball
Lets.play.basketball
teaguear
Garricks-Updated Resume-VA15
Garricks-Updated Resume-VA15
Garrick AUGUSTUS
Bai tap viet cau voi tu goi y trong ngoac
Bai tap viet cau voi tu goi y trong ngoac
phuongpham2003
International Journal of Computational Engineering Research (IJCER) is dedicated to protecting personal information and will make every reasonable effort to handle collected information appropriately. All information collected, as well as related requests, will be handled as carefully and efficiently as possible in accordance with IJCER standards for integrity and objectivity.
Electronic Identification System using RFID
Electronic Identification System using RFID
ijceronline
salvation ppt
salvation ppt
guestf87992
Simplified Receptor Based Pharmacophore Approach to Retrieve Potent PTP-LAR Inhibitors Using Apoenzyme M. Elizabeth Sobhia* Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab 160062, India Abstract: The design of biological active compounds from the apoenzyme is still a challenging task. Herein a simple yet efficient technique is reported to generate a receptor based pharmacophore solely using a ligand-free protein crystal structure. Human leukocyte antigen-related phosphatase (PTP-LAR) is an apoenzyme and a receptor like transmembrane phosphatase that has emerged as a drug target for diabetes, obesity and cancer. The prior knowledge of the active residues responsible for the mechanism of action of the protein was used to generate the LUDI interaction map. Then, the complement negative image of the binding site was used to generate the pharmacophore features. A unique strategy was followed to design a pharmacophore query maintaining crucial interactions with all the active residues, essential for the enzyme inhibition. The same query was used to screen several databases consisting of the Specs, IBS, iniMaybridge, NCI and an in-house PTP inhibitor databases. In order to overcome the common bioavailability problem associated with phosphatases, the hits obtained were filtered by Lipinski’s Rule of Five, SADMET properties and validated by docking studies in Glide and GOLD. These docking studies not only suggest the essential ligand binding interactions but also the binding patterns necessary for the LAR inhibition. The ligand pharmacophore mapping studies further validated the screened protocol and supported that the final screened molecules, presumably, showed potent inhibitory activity. Subsequently, these molecules were subjected to Derek toxicity predictions and nine new molecules with different scaffold were obtained as non-toxic PTP-LAR inhibitors. The present prospective strategy is a powerful technique to identify potent inhibitors using the protein 3D structure alone and is a valid alternative to other structure-based and random docking approaches.
Simplified receptor based pharmacophore approach to retrieve potent ptp lar i...
Simplified receptor based pharmacophore approach to retrieve potent ptp lar i...
rajmaha9
Sections and Details for Phoenix Village
S200 s206 phoenix village
S200 s206 phoenix village
Adam Brooke
For further details contact: N.RAJASEKARAN B.E M.S 9841091117,9840103301. IMPULSE TECHNOLOGIES, Old No 251, New No 304, 2nd Floor, Arcot road , Vadapalani , Chennai-26.
Esm
Esm
IMPULSE_TECHNOLOGY
Sistemas1002
Sistemas1002
michellerincon98
All about pronouns.. Hope this will help. :)
Pronouns
Pronouns
Irele Balmaceda
Dans le Design fax n° 967 : Les gros mots du design avec la chronique de Christophe Chaptal de Chanteloup. Cette semaine, "Design Biduling".
Design fax 967 | Les gros mots du design | Design Biduling
Design fax 967 | Les gros mots du design | Design Biduling
Christophe Chaptal de Chanteloup
An English translation of Qiang （羌） references in the Later Han Histories or Hou Han Shu (后汉书）.
Qiang 羌 references in the Book of the Later Han 后汉书
Qiang 羌 references in the Book of the Later Han 后汉书
qianghistory
INSTRUCTOR BLS AED Nu.381-15-114565-02-06
INSTRUCTOR BLS AED Nu.381-15-114565-02-06
Elvir Ligata
Workshop slide deck for iPadpalooza 2016. Please note the videos will not play but they are all in the G+ community https://plus.google.com/u/0/communities/101416752034019971438
Make du Jour ipadpalooza16
Make du Jour ipadpalooza16
Amy Burvall
This solution manual is for CSC 183 (IUBAT)
The solution manual of c by robin
The solution manual of c by robin
Abdullah Al Naser
Matrik
Matrik
bagus222
Could you summarize this passage?
Could you summarize this passage?
fedeunrraorfocheal
Report of Seeds of Empowerment,1001 stories project in India. Read more about Seeds at www.seedsofempowerment.org
1001 stories Seeds of Empowerment
1001 stories Seeds of Empowerment
Seeds Empowerment
Item 18 : Yong Kang 15 (Remaned as Ice Monster) & relocated to 1F.,No.297,Sec.4 Zhongxiao E.Rd.,Da' an Dist.,Taipei City 106,Taiwan.
Taiwanese Cuisines 台灣美食
Taiwanese Cuisines 台灣美食
Roy Chung
Babasaheb javca
Babasaheb javca
Babasaheb Pawar
More Related Content
Viewers also liked
Lets.play.basketball
Lets.play.basketball
teaguear
Garricks-Updated Resume-VA15
Garricks-Updated Resume-VA15
Garrick AUGUSTUS
Bai tap viet cau voi tu goi y trong ngoac
Bai tap viet cau voi tu goi y trong ngoac
phuongpham2003
International Journal of Computational Engineering Research (IJCER) is dedicated to protecting personal information and will make every reasonable effort to handle collected information appropriately. All information collected, as well as related requests, will be handled as carefully and efficiently as possible in accordance with IJCER standards for integrity and objectivity.
Electronic Identification System using RFID
Electronic Identification System using RFID
ijceronline
salvation ppt
salvation ppt
guestf87992
Simplified Receptor Based Pharmacophore Approach to Retrieve Potent PTP-LAR Inhibitors Using Apoenzyme M. Elizabeth Sobhia* Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab 160062, India Abstract: The design of biological active compounds from the apoenzyme is still a challenging task. Herein a simple yet efficient technique is reported to generate a receptor based pharmacophore solely using a ligand-free protein crystal structure. Human leukocyte antigen-related phosphatase (PTP-LAR) is an apoenzyme and a receptor like transmembrane phosphatase that has emerged as a drug target for diabetes, obesity and cancer. The prior knowledge of the active residues responsible for the mechanism of action of the protein was used to generate the LUDI interaction map. Then, the complement negative image of the binding site was used to generate the pharmacophore features. A unique strategy was followed to design a pharmacophore query maintaining crucial interactions with all the active residues, essential for the enzyme inhibition. The same query was used to screen several databases consisting of the Specs, IBS, iniMaybridge, NCI and an in-house PTP inhibitor databases. In order to overcome the common bioavailability problem associated with phosphatases, the hits obtained were filtered by Lipinski’s Rule of Five, SADMET properties and validated by docking studies in Glide and GOLD. These docking studies not only suggest the essential ligand binding interactions but also the binding patterns necessary for the LAR inhibition. The ligand pharmacophore mapping studies further validated the screened protocol and supported that the final screened molecules, presumably, showed potent inhibitory activity. Subsequently, these molecules were subjected to Derek toxicity predictions and nine new molecules with different scaffold were obtained as non-toxic PTP-LAR inhibitors. The present prospective strategy is a powerful technique to identify potent inhibitors using the protein 3D structure alone and is a valid alternative to other structure-based and random docking approaches.
Simplified receptor based pharmacophore approach to retrieve potent ptp lar i...
Simplified receptor based pharmacophore approach to retrieve potent ptp lar i...
rajmaha9
Sections and Details for Phoenix Village
S200 s206 phoenix village
S200 s206 phoenix village
Adam Brooke
For further details contact: N.RAJASEKARAN B.E M.S 9841091117,9840103301. IMPULSE TECHNOLOGIES, Old No 251, New No 304, 2nd Floor, Arcot road , Vadapalani , Chennai-26.
Esm
Esm
IMPULSE_TECHNOLOGY
Sistemas1002
Sistemas1002
michellerincon98
All about pronouns.. Hope this will help. :)
Pronouns
Pronouns
Irele Balmaceda
Dans le Design fax n° 967 : Les gros mots du design avec la chronique de Christophe Chaptal de Chanteloup. Cette semaine, "Design Biduling".
Design fax 967 | Les gros mots du design | Design Biduling
Design fax 967 | Les gros mots du design | Design Biduling
Christophe Chaptal de Chanteloup
An English translation of Qiang （羌） references in the Later Han Histories or Hou Han Shu (后汉书）.
Qiang 羌 references in the Book of the Later Han 后汉书
Qiang 羌 references in the Book of the Later Han 后汉书
qianghistory
INSTRUCTOR BLS AED Nu.381-15-114565-02-06
INSTRUCTOR BLS AED Nu.381-15-114565-02-06
Elvir Ligata
Workshop slide deck for iPadpalooza 2016. Please note the videos will not play but they are all in the G+ community https://plus.google.com/u/0/communities/101416752034019971438
Make du Jour ipadpalooza16
Make du Jour ipadpalooza16
Amy Burvall
This solution manual is for CSC 183 (IUBAT)
The solution manual of c by robin
The solution manual of c by robin
Abdullah Al Naser
Matrik
Matrik
bagus222
Could you summarize this passage?
Could you summarize this passage?
fedeunrraorfocheal
Report of Seeds of Empowerment,1001 stories project in India. Read more about Seeds at www.seedsofempowerment.org
1001 stories Seeds of Empowerment
1001 stories Seeds of Empowerment
Seeds Empowerment
Item 18 : Yong Kang 15 (Remaned as Ice Monster) & relocated to 1F.,No.297,Sec.4 Zhongxiao E.Rd.,Da' an Dist.,Taipei City 106,Taiwan.
Taiwanese Cuisines 台灣美食
Taiwanese Cuisines 台灣美食
Roy Chung
Babasaheb javca
Babasaheb javca
Babasaheb Pawar
Viewers also liked
(20)
Lets.play.basketball
Lets.play.basketball
Garricks-Updated Resume-VA15
Garricks-Updated Resume-VA15
Bai tap viet cau voi tu goi y trong ngoac
Bai tap viet cau voi tu goi y trong ngoac
Electronic Identification System using RFID
Electronic Identification System using RFID
salvation ppt
salvation ppt
Simplified receptor based pharmacophore approach to retrieve potent ptp lar i...
Simplified receptor based pharmacophore approach to retrieve potent ptp lar i...
S200 s206 phoenix village
S200 s206 phoenix village
Esm
Esm
Sistemas1002
Sistemas1002
Pronouns
Pronouns
Design fax 967 | Les gros mots du design | Design Biduling
Design fax 967 | Les gros mots du design | Design Biduling
Qiang 羌 references in the Book of the Later Han 后汉书
Qiang 羌 references in the Book of the Later Han 后汉书
INSTRUCTOR BLS AED Nu.381-15-114565-02-06
INSTRUCTOR BLS AED Nu.381-15-114565-02-06
Make du Jour ipadpalooza16
Make du Jour ipadpalooza16
The solution manual of c by robin
The solution manual of c by robin
Matrik
Matrik
Could you summarize this passage?
Could you summarize this passage?
1001 stories Seeds of Empowerment
1001 stories Seeds of Empowerment
Taiwanese Cuisines 台灣美食
Taiwanese Cuisines 台灣美食
Babasaheb javca
Babasaheb javca
Xianweijing
1.
显微镜下的世界
2.
显微镜的构造 接目鏡 鏡筒 粗調節輪 旋轉盤 接物鏡 細 調 壓條 載物台 拿显微镜的正确方法 節 輪 光圈 反光鏡 17 世纪人类发明了光学显微镜，使人类可以观 察微生物。 座鏡
3.
4.
在玻璃片中央放入要观察的物体 。
5.
6.
显微镜使用时的顺序： ＊先使用低倍物镜 (1) (2) (3) (4) (5) 把玻璃片物体对准镜头圆孔，并固定夹注。 转动粗调节轮 调节反光镜及光圈。 转动粗调节轮。直到看到清楚的标本。 低倍镜观察后，换高倍镜，并细调。
7.
8.
9.
10.
11.
显微镜下放大 25 倍的海 水
12.
螃蟹的幼体
13.
蓝藻
14.
藻类
15.
鱼卵
16.
卢治强师整理 2014
Download now
