Applying innovative commercial technology to deliver on the promise of personalized medicine -  Enakshi	Singh
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Applying innovative commercial technology to deliver on the promise of personalized medicine - Enakshi Singh

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CityAge: The Data Effect

CityAge: The Data Effect

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  • 1. Applying  innova,ve  commercial  technology  to   deliver  on  the  promise  of  personalized  medicine     Enakshi  Singh,  M.Sc.   SAP  Product  Management     SAP  HANA  Pla6orm  for  Healthcare   Public  
  • 2. SAP powers analytics that SAP customers represent 86% of Global Fortune 500 companies. 74% of the world’s transaction revenue touches an SAP system. Our customers produce more than 82% of the world’s medical devices. track more than 6 billion U.S. stock trades per day to identify fraud and protect investors. Our customers distribute more than 76% of the world’s healthcare products. Our customers produce more than 77% of the world’s beer. Public  
  • 3.     But  can  you  apply  the  latest   technology  developments  and   capabili>es  to  further  healthcare   research?   Dr. Hasso Plattner, Founder and Chairman of SAP Supervisory Board Public  
  • 4. Our  Vision:  Enable  Personalized   Medicine     Lifestyle  Data   SAP  HANA     Pla@orm   For   Healthcare   Clinical  Data   (EMRs)   Biological  Data   (-­‐Omics  Data  +   Annota>ons)   Can  we  interpret  all  pa>ent  data   during  a  pa>ent’s  visit?   Real-­‐>me  Data     Capture  &  Analysis   All  Relevant  Medical     Informa>on   Public  
  • 5. Vision:  SAP  HANA  Healthcare   Pla6orm   Informa>on  and  Feedback  within  the  Window  of  Opportunity   Pa>ents   Doctors   Insurers   Researchers   Real-­‐Time  Data  Capture   and  Analysis   SAP  HANA  Healthcare  Pla6orm   Biological  Data   (e.g.  genomics)   Clinical  Data   (e.g.  EMRs)   Lifestyle  Data   (Care  Circles)   Lifestyle  Data   ... All  Relevant  Medical  Informa>on   Public  
  • 6. In-­‐Memory  Technology  Building   Blocks   ● ● ● ● Read Event Read Event Repositories Repositories Combined  column   and  row  store     +   up to 2.000 up to 2.000 requests requests per second per second Minimal   projec>ons   Any  aVribute   as  index   Bulk  load   Discovery Service Discovery Service Mul>-­‐core/   paralleliza>on   SAP HANA SAP HANA No  aggregate   tables   On-­‐the-­‐fly   extensibility   Map  reduce   P P t   A A Lightweight   Compression   Par>>oning   SQL   Analy>cs  on   historical  data   Single  and   mul>-­‐tenancy   Object  to     rela>onal   mapping     Group  Key   SQL  interface  on   columns  &  rows   Reduc>on  of   layers   x x P Ac>ve/passive   data  store   Dynamic  mul>-­‐ threading   within  nodes   +  +  +   up to 8.000 read up to 8.000 read event notifications event notifications per second per second Insert  only   for  >me  travel   +   +   +  +   A Verification Verification Services Services T   Text  Retrieval   and  Extrac>on   No  disk   Public  
  • 7. ● ● ● ● Read Event Read Event Repositories Repositories Verification Verification Services Services SAP  HANA  Database  Technology   up to 8.000 read up to 8.000 read event notifications event notifications per second per second up to 2.000 up to 2.000 requests requests per second per second Discovery Service Discovery Service T   SAP HANA SAP HANA Bulk  load    P A A P Fast  inser,on  of    large   genomic  datasets  or   other  relevant   datasets     Text  Retrieval   and  Extrac>on   Search  doctor’s  notes,   diagnoses,  etc. (unstructured  data)     Lightweight   Compression   Fit  big  data  in  main   memory  while   allowing  fast  retrieval     SQL   +  +  +   Mul>-­‐core/   paralleliza>on   Speedup  of  relevant   queries  across  many   nodes   SQL  interface  on   columns  &  rows   Easily  connect   with  other  tools   (e.g.  Rstudio)   On-­‐the-­‐fly   extensibility   Adap,ng  to  new   format  requirements   without  going  offline   (e.g.  changing  VCF   files)   Public  
  • 8. Genomics  &  Big  Data   Public  
  • 9. SAP  and  Stanford   Human  Popula>on  Genomics  and  Global  Health   “   ”   "We  have  been  thrilled  to  work  with  SAP  and  HPI  on  a  collabora,on  to  accelerate  DNA  sequence  analysis.  In  our  pilot   projects,  we  are  seeing  drama,c  speedups  in  compu,ng  on  human  genome  varia,on  data  from  many  samples.  We  are   dreaming  of  what  will  soon  be  possible  as  we  integrate  phenotype,  genomics,  proteomics,  and  expose  data  to  empower   complex  trait  mapping  using  millions  of  health  records.”     -­‐  Professor  Carlos  D.  Bustamante  at  the  Stanford  University  School  of  Medicine       Dr. Carlos D. Bustamante   Analyze  genome  wide  paVerns  of  varia>on  within  and   between  species  to  address  fundamental  ques>ons  in   biology,  anthropology,  and  medicine:  implica,ons  for  global   health  and  disease   SAP  HANA  to  contribute  to  all  parts  of  computa>onal  pipeline     Sequencing   Pa>ent   Samples   Alignment   Raw  DNA   Reads     Mapped   Genome   Variant  Calling   Annota,on  and  Analysis   Discovered     Variants   Follow-­‐up   and   Valida>on   Public  
  • 10. SAP  HANA  for  Healthcare:     Genome  Analysis  Applica>on   Computa>onal  Pipeline   e.g.  Bioinforma>cian   Sequencing  Service/Lab   e.g.  Biologist   Sequencing   Pa>ent   Samples   •  Alignment   Raw  DNA   Reads   Computa>onal  Analysis   e.g.  Clinicians  AND  Researchers   Variant  Calling   Mapped   Genome   Annota,on  and  Analysis   Discovered     Variants   Follow-­‐up   and   Valida>on   All  steps  a`er  sequencing  will  be  supported  within  the  genome  analysis   applica>on  (from  raw  DNA  reads  to  annota>on  &  analysis)   -    Real-­‐>me  analyses  of  large-­‐scale  genome  variant  datasets   -  Implement  read  alignment,  variant  calling  &  all  other  relevant  “-­‐omic”  algorithms  in   HANA  database     -  Create  data  models  to  have  readily  available  latest  annota>ons  (literature/metadata)   from  open-­‐source  (and  poten>ally  commercial)  biological  databases     Public  
  • 11.   SAP  and  NCT   •  Medical  Explorer  For  ALL  Pa>ent  Data   The National Center for Tumor Diseases (NCT) Heidelberg provides patient   care, cancer research and cancer prevention united under one roof. •  Integrated content from various sources of structured (tumor documentation, medical records, clinical trials) and unstructured (doctor letters, treatment guidelines, trial reports, publications) nature. •  Medical records from 150,000 patients and 3,600,000 interactions, and a selection of doctor letters from 120 doctors A  search  for  lung  carcinoma  pa>ents  (only  NSCLC)  with  an  overexpressed  Epidermal  Growth  Factor  Receptor  (EGFR)  known  to  be  a  target  for   Tyrosine  Kinase  Inhibitors  (TKIs)  which  inhibit  the  EGFR  pathway.  In  this  example,  the  informa>on  on    EGFR  is  gathered  by  a  seman>c  text  analysis   of  the  pa>ents’  doctor  leVers.   Public  
  • 12. Co-­‐Innova>on:     SAP  &  PHEMI  Health  Systems   The  speed  of  SAP  HANA  and  the  Privacy  by  Design  infrastructure  of   PHEMI  Health  Systems  will  allow  healthcare  professionals  to  analyze   vast  amounts  of  data  thereby  enabling:   •  Lower  costs  by  quickly  discovering  what  works  and  what  doesn’t.   •  Improve  pa,ent  care  by  analyzing  a  pa>ent’s  DNA  sequence  and   using  that  informa>on  to  decide  on  the  op>mal  drug,  thereby   personalizing  the  pa>ent’s  treatment.   •  Reduce  wait  ,mes  by  improving  hospital  clinic  efficiency  and   forecas>ng  popula>on  health  to  determine  where  and  when  to   increase  health  care  capacity   •  Provide  privacy  of  sensi>ve  pa>ent  informa>on,  an  impera>ve  in   healthcare.     Public  
  • 13. New  Ways  of  Real-­‐Time  Collabora>ve   Personalized  Medicine   Public  
  • 14. Thank  you   Contact  informa>on:   hana-­‐healthcare-­‐pla6orm@sap.com   Enakshi  Singh   Enakshi.Singh@sap.com    
  • 15. ©  2012  SAP  AG.  All  rights  reserved.   No  part  of  this  publica>on  may  be  reproduced  or  transmiVed  in  any  form  or  for  any  purpose  without   the  express  permission  of  SAP  AG.  The  informa>on  contained  herein  may  be  changed  without  prior   no>ce.   Some  so`ware  products  marketed  by  SAP  AG  and  its  distributors  contain  proprietary  so`ware   components  of  other  so`ware  vendors.   Microso`,  Windows,  Excel,  Outlook,  PowerPoint,  Silverlight,  and  Visual  Studio  are  registered   trademarks  of  Microso`  Corpora>on.     IBM,  DB2,  DB2  Universal  Database,  System  i,  System  i5,  System  p,  System  p5,  System  x,  System  z,   System  z10,  z10,  z/VM,  z/OS,  OS/390,  zEnterprise,  PowerVM,  Power  Architecture,  Power  Systems,   POWER7,  POWER6+,  POWER6,  POWER,  PowerHA,  pureScale,  PowerPC,  BladeCenter,  System  Storage,   Storwize,  XIV,  GPFS,  HACMP,  RETAIN,  DB2  Connect,  RACF,  Redbooks,  OS/2,  AIX,  Intelligent  Miner,   WebSphere,  Tivoli,  Informix,  and  Smarter  Planet  are  trademarks  or  registered  trademarks  of  IBM   Corpora>on.   Linux  is  the  registered  trademark  of  Linus  Torvalds  in  the  United  States  and  other  countries.   Adobe,  the  Adobe  logo,  Acrobat,  PostScript,  and  Reader  are  trademarks  or  registered  trademarks  of   Adobe  Systems  Incorporated  in  the  United  States  and  other  countries.   Oracle  and  Java  are  registered  trademarks  of  Oracle  and  its  affiliates.   UNIX,  X/Open,  OSF/1,  and  Mo>f  are  registered  trademarks  of  the  Open  Group.   Citrix,  ICA,  Program  Neighborhood,  MetaFrame,  WinFrame,  VideoFrame,  and  Mul>Win     are  trademarks  or  registered  trademarks  of  Citrix  Systems  Inc.   HTML,  XML,  XHTML,  and  W3C  are  trademarks  or  registered  trademarks  of  W3C®,     World  Wide  Web  Consor>um,  MassachuseVs  Ins>tute  of  Technology.     Apple,  App  Store,  iBooks,  iPad,  iPhone,  iPhoto,  iPod,  iTunes,  Mul>-­‐Touch,  Objec>ve-­‐C,  Re>na,  Safari,   Siri,  and  Xcode  are  trademarks  or  registered  trademarks  of  Apple  Inc.   IOS  is  a  registered  trademark  of  Cisco  Systems  Inc.   RIM,  BlackBerry,  BBM,  BlackBerry  Curve,  BlackBerry  Bold,  BlackBerry  Pearl,  BlackBerry  Torch,   BlackBerry  Storm,  BlackBerry  Storm2,  BlackBerry  PlayBook,  and  BlackBerry  App  World  are   trademarks  or  registered  trademarks  of  Research  in  Mo>on  Limited.   Google  App  Engine,  Google  Apps,  Google  Checkout,  Google  Data  API,  Google  Maps,  Google  Mobile   Ads,  Google  Mobile  Updater,  Google  Mobile,  Google  Store,  Google  Sync,  Google  Updater,  Google   Voice,  Google  Mail,  Gmail,  YouTube,  Dalvik  and  Android  are  trademarks  or  registered  trademarks  of   Google  Inc.   INTERMEC  is  a  registered  trademark  of  Intermec  Technologies  Corpora>on.   Wi-­‐Fi  is  a  registered  trademark  of  Wi-­‐Fi  Alliance.   Bluetooth  is  a  registered  trademark  of  Bluetooth  SIG  Inc.   Motorola  is  a  registered  trademark  of  Motorola  Trademark  Holdings  LLC.     Computop  is  a  registered  trademark  of  Computop  Wirtscha`sinforma>k  GmbH.   SAP,  R/3,  SAP  NetWeaver,  Duet,  PartnerEdge,  ByDesign,  SAP  BusinessObjects  Explorer,  StreamWork,   SAP  HANA,  and  other  SAP  products  and  services  men>oned  herein  as  well  as  their  respec>ve  logos   are  trademarks  or  registered  trademarks  of  SAP  AG  in  Germany  and  other  countries.   Business  Objects  and  the  Business  Objects  logo,  BusinessObjects,  Crystal  Reports,  Crystal  Decisions,   Web  Intelligence,  Xcelsius,  and  other  Business  Objects  products  and  services  men>oned  herein  as   well  as  their  respec>ve  logos  are  trademarks  or  registered  trademarks  of  Business  Objects  So`ware   Ltd.  Business  Objects  is  an  SAP  company.   Sybase  and  Adap>ve  Server,  iAnywhere,  Sybase  365,  SQL  Anywhere,  and  other  Sybase  products  and   services  men>oned  herein  as  well  as  their  respec>ve  logos  are  trademarks  or  registered  trademarks   of  Sybase  Inc.  Sybase  is  an  SAP  company.   Crossgate,  m@gic  EDDY,  B2B  360°,  and  B2B  360°  Services  are  registered  trademarks  of  Crossgate  AG   in  Germany  and  other  countries.  Crossgate  is  an  SAP  company.   All  other  product  and  service  names  men>oned  are  the  trademarks  of  their  respec>ve  companies.   Data  contained  in  this  document  serves  informa>onal  purposes  only.  Na>onal  product  specifica>ons   may  vary.   The  informa>on  in  this  document  is  proprietary  to  SAP.  No  part  of  this  document  may  be   reproduced,  copied,  or  transmiVed  in  any  form  or  for  any  purpose  without  the  express  prior  wriVen   permission  of  SAP  AG.   Public  
  • 16. ©  2012  SAP  AG.  Alle  Rechte  vorbehalten.   Weitergabe  und  Vervielfäl>gung  dieser  Publika>on  oder  von  Teilen  daraus  sind,  zu  welchem  Zweck   und  in  welcher  Form  auch  immer,  ohne  die  ausdrückliche  schri`liche  Genehmigung  durch  SAP  AG   nicht  gestaVet.  In  dieser  Publika>on  enthaltene  Informa>onen  können  ohne  vorherige  Ankündigung   geändert  werden.   Google  App  Engine,  Google  Apps,  Google  Checkout,  Google  Data  API,  Google  Maps,  Google  Mobile   Ads,  Google  Mobile  Updater,  Google  Mobile,  Google  Store,  Google  Sync,  Google  Updater,  Google   Voice,  Google  Mail,  Gmail,  YouTube,  Dalvik  und  Android  sind  Marken  oder  eingetragene  Marken  von   Google  Inc.   Die  von  SAP  AG  oder  deren  Vertriebsfirmen  angebotenen  So`wareprodukte  können   So`warekomponenten  auch  anderer  So`warehersteller  enthalten.   INTERMEC  ist  eine  eingetragene  Marke  der  Intermec  Technologies  Corpora>on.   Microso`,  Windows,  Excel,  Outlook,  PowerPoint,  Silverlight  und  Visual  Studio  sind  eingetragene   Marken  der  Microso`  Corpora>on.     IBM,  DB2,  DB2  Universal  Database,  System  i,  System  i5,  System  p,  System  p5,  System  x,  System  z,   System  z10,  z10,  z/VM,  z/OS,  OS/390,  zEnterprise,  PowerVM,  Power  Architecture,  Power  Systems,   POWER7,  POWER6+,  POWER6,  POWER,  PowerHA,  pureScale,  PowerPC,  BladeCenter,  System  Storage,   Storwize,  XIV,  GPFS,  HACMP,  RETAIN,  DB2  Connect,  RACF,  Redbooks,  OS/2,  AIX,  Intelligent  Miner,   WebSphere,  Tivoli,  Informix  und  Smarter  Planet  sind  Marken  oder  eingetragene  Marken  der  IBM   Corpora>on.   Linux  ist  eine  eingetragene  Marke  von  Linus  Torvalds  in  den  USA  und  anderen  Ländern.   Adobe,  das  Adobe-­‐Logo,  Acrobat,  PostScript  und  Reader  sind  Marken  oder  eingetragene  Marken  von   Adobe  Systems  Incorporated  in  den  USA  und/oder  anderen  Ländern.   Oracle  und  Java  sind  eingetragene  Marken  von  Oracle  und/oder  ihrer  Tochtergesellscha`en.     UNIX,  X/Open,  OSF/1  und  Mo>f  sind  eingetragene  Marken  der  Open  Group.   Citrix,  ICA,  Program  Neighborhood,  MetaFrame,  WinFrame,  VideoFrame  und  Mul>Win     sind  Marken  oder  eingetragene  Marken  von  Citrix  Systems,  Inc.   HTML,  XML,  XHTML  und  W3C  sind  Marken  oder  eingetragene  Marken  des  W3C®,     World  Wide  Web  Consor>um,  MassachuseVs  Ins>tute  of  Technology.     Apple,  App  Store,  iBooks,  iPad,  iPhone,  iPhoto,  iPod,  iTunes,  Mul>-­‐Touch,  Objec>ve-­‐C,  Re>na,  Safari,   Siri  und  Xcode  sind  Marken  oder  eingetragene  Marken  der  Apple  Inc.   IOS  ist  eine  eingetragene  Marke  von  Cisco  Systems  Inc.   RIM,  BlackBerry,  BBM,  BlackBerry  Curve,  BlackBerry  Bold,  BlackBerry  Pearl,  BlackBerry  Torch,   BlackBerry  Storm,  BlackBerry  Storm2,  BlackBerry  PlayBook  und  BlackBerry  App  World  sind  Marken   oder  eingetragene  Marken  von  Research  in  Mo>on  Limited.   Wi-­‐Fi  ist  eine  eingetragene  Marke  der  Wi-­‐Fi  Alliance.   Bluetooth  ist  eine  eingetragene  Marke  von  Bluetooth  SIG  Inc.   Motorola  ist  eine  eingetragene  Marke  von  Motorola  Trademark  Holdings,  LLC.     Computop  ist  eine  eingetragene  Marke  der  Computop  Wirtscha`sinforma>k  GmbH.   SAP,  R/3,  SAP  NetWeaver,  Duet,  PartnerEdge,  ByDesign,  SAP  BusinessObjects  Explorer,  StreamWork,   SAP  HANA  und  weitere  im  Text  erwähnte  SAP-­‐Produkte  und  -­‐Dienst-­‐leistungen  sowie  die   entsprechenden  Logos  sind  Marken  oder  eingetragene  Marken  der  SAP  AG  in  Deutschland  und   anderen  Ländern.   Business  Objects  und  das  Business-­‐Objects-­‐Logo,  BusinessObjects,  Crystal  Reports,  Crystal  Decisions,   Web  Intelligence,  Xcelsius  und  andere  im  Text  erwähnte  Business-­‐Objects-­‐Produkte  und  -­‐ Dienstleistungen  sowie  die  entsprechenden  Logos  sind  Marken     oder  eingetragene  Marken  der  Business  Objects  So`ware  Ltd.  Business  Objects  ist  ein  Unternehmen   der  SAP  AG.   Sybase  und  Adap>ve  Server,  iAnywhere,  Sybase  365,  SQL  Anywhere  und  weitere  im  Text  erwähnte   Sybase-­‐Produkte  und  -­‐Dienstleistungen  sowie  die  entsprechenden  Logos  sind  Marken  oder   eingetragene  Marken  der  Sybase  Inc.  Sybase  ist  ein  Unternehmen  der   SAP  AG.   Crossgate,  m@gic  EDDY,  B2B  360°,  B2B  360°  Services  sind  eingetragene  Marken     der  Crossgate  AG  in  Deutschland  und  anderen  Ländern.  Crossgate  ist  ein  Unternehmen  der  SAP  AG.   Alle  anderen  Namen  von  Produkten  und  Dienstleistungen  sind  Marken  der  jeweiligen  Firmen.  Die   Angaben  im  Text  sind  unverbindlich  und  dienen  lediglich  zu  Informa>ons-­‐zwecken.  Produkte  können   länderspezifische  Unterschiede  aufweisen.   Die  in  dieser  Publika>on  enthaltene  Informa>on  ist  Eigentum  der  SAP.  Weitergabe  und   Vervielfäl>gung  dieser  Publika>on  oder  von  Teilen  daraus  sind,  zu  welchem  Zweck  und     in  welcher  Form  auch  immer,  nur  mit  ausdrücklicher  schri`licher  Genehmigung  durch     SAP  AG  gestaVet.   Public