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Chromatography: Biopharm Higher Order Structure & Conformation Stability Analysis with HDX

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(originally aired 03-27-12) …

(originally aired 03-27-12)

Regulators are encouraging the biopharmaceutical industry to improve therapeutic antibody characterization of protein therapeutics when performing drug safety evaluations, especially important for higher order structure integrity, conformation stability, and epitope mapping. However, previously there was no widely available, high-resolution, analytical method to characterize protein therapeutics in solutions. Hydrogen/deuterium-exchange mass spectrometry (HDX-MS) is increasingly popular with academia and industry investigating protein dynamics, as well as protein-ligand and protein-protein interactions. Join experts in the field to learn the fundamentals of HDX-MS, and how recent development of automation and data-extraction software enables its application to biopharmaceutical protein characterization and development.


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