4 faces of diabetes

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There are four diabetes types one and two
gestational and that caused by iron overload the question is are they all caused by too much iron

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4 faces of diabetes

  1. 1. <ul><li>Type I Juvenile Diabetes (genetic) </li></ul><ul><li>Type II Adult onset (acquired) </li></ul><ul><li>Gestational (war in the womb) </li></ul><ul><li>Iron Overload (Fe induced) </li></ul><ul><li>Only in one of these Diabetes is the cause known </li></ul>Chris YUKNA Science General Ecole des Mines Saint Etienne [email_address]
  2. 2. Type 1 diabetes formerly, juvenile diabetes <ul><li>pancreatic beta cells in the Islets of Langerhans are destroyed decreasing endogenous insulin production. </li></ul><ul><li>One theory, by DeLisa Fairweather et al, ,[13] proposes that type 1 diabetes is a virally triggered autoimmune response in which the immune system attacks virus infected cells along with the beta cells in the pancreas. The Coxsackie virus family or Rubella is implicated, although the evidence is inconclusive. </li></ul><ul><li>There is a growing body of evidence that diet may play a role in the development of type 1 diabetes, through influencing gut flora, intestinal permeability, and immune function in the gut; wheat in particular has been shown to have a connection to the development of type 1 diabetes, although the relationship is poorly understood.[15] </li></ul><ul><li>Some researchers believe that the autoimmune response is influenced by antibodies against cow's milk proteins.[16 </li></ul>Chris YUKNA Science General Ecole des Mines Saint Etienne [email_address]
  3. 3. Diabetes mellitus type 2 <ul><li>is often initially managed by increasing exercise and dietary modification </li></ul><ul><li>Insulin resistance is a precurser </li></ul><ul><li>Low salt diets increase insulin resistance </li></ul><ul><li>Long-term complications can include increased risk of heart attacks, strokes, kidney failure loss of hearing, eyesight, and cognitive ability has also been linked to this condition. </li></ul><ul><li>Obesity is a risk factor </li></ul><ul><li>About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes </li></ul>Chris YUKNA Science General Ecole des Mines Saint Etienne [email_address]
  4. 4. Gestational Diabetes <ul><li>Women exhibit high blood glucose levels during pregnancy (especially during third trimester of pregnancy) because they do not produce enough insulin. It is widely accepted as a disease only in the United States, there is some question whether the condition is natural during pregnancy . </li></ul><ul><li>babies born to mothers with gestational diabetes are typically at increased risk of problems such as being large for gestational age , low blood sugar, and jaundice. </li></ul><ul><li>Women with gestational diabetes are at increased risk of developing type 2 diabetes mellitus (or, very rarely, latent autoimmune diabetes or Type 1) after pregnancy, as well as having a higher incidence of pre-eclampsia and Caesarean section; their offspring are prone to developing childhood obesity, with type 2 diabetes later in life </li></ul><ul><li>BTW pre-eclampsia is just a fancy name for pregnancy-induced hypertension </li></ul><ul><li>Women who have recently given birth have a short-term increase in (cancer) risk that declines after about 10 years. The reason for this temporary increase is not known, but some researchers believe that it may be due to the effect of high levels of hormones on microscopic cancers or to the rapid growth of breast cells during pregnancy (15). </li></ul>Chris YUKNA Science General Ecole des Mines Saint Etienne [email_address]
  5. 5. Iron Overload or iron storage disease <ul><li>“ The most important causes are hereditary hemochromatosis (HHC), a genetic disease, and transfusional iron overload, which can result from repeated blood transfusion.” Wikipedia Iron Overload </li></ul><ul><li>This ignores African iron overload or African siderosis a condition first observed in sub-Saharan Africans. This is a diet related overload principally from beer brewed in iron containers. </li></ul><ul><li>Iron overload causes diabetes due to pancreatic islet cell failure </li></ul><ul><li>Iron overload is multi-symptomatic as opposed to multi-factorial </li></ul><ul><li>Both the genetic as well as the acquired form strike men more often than women because women can regulate in part their iron load via menstration. </li></ul>Chris YUKNA Science General Ecole des Mines Saint Etienne [email_address]
  6. 6. Iron & Gestational Diabetes <ul><li>Women often take multivitamins with iron even worse there are neonatal protocols that suggest to women that they should take iron supplements during pregnancy. Here is a typical example Bayer's Elevit B9 which contains 60 mgs of iron (Ferrous Fumarate) in each dose . </li></ul><ul><li>babies born to mothers with gestational diabetes are larger (typical of iron suppliments) jaundiced typical of too much iron affecting the liver . </li></ul><ul><li>Pre-eclampsiae or pregnancy-induced hypertension is symptomatic of iron overload </li></ul><ul><li>Wouldn't pregnant women, who do not menstruate, would have a similar profile to a man? </li></ul><ul><li>Women who have recently given birth have a short-term increase in (cancer) risk that declines after about 10 years. Links between cancer and iron have been documented since the 1950s </li></ul><ul><li>Biro-accumulation and placental exchanges would mean that the children of iron loaded mothers would themselves start out life with a higher iron load. </li></ul>Chris YUKNA Science General Ecole des Mines Saint Etienne [email_address]
  7. 7. Diabetes mellitus type 1 & 2 <ul><li>Type 2 Americans, in particular, live in a world where a bowl of fortified cornflakes has more iron than a hamburger. Becoming iron loaded enough to provoke diabetes should be child's play. </li></ul><ul><li>What explosive effect would industrialised iron enriched food have on the microbiota living in the gut? Would they shift from a symbiotic relationship to one of parasitism? Could this explain why a higher salt diet might temper insulin resistance? </li></ul><ul><li>Pancreatic cancer patients having glucose intolerance or frank diabetes would be logical if the root cause is the same </li></ul><ul><li>This goes double for increased risk of heart attacks, strokes, kidney failure etc which are well know complications of Iron Overload. </li></ul><ul><li>Is Obesity linked to iron? </li></ul><ul><li>Type I An iron overload baby who will develop type one diabetes, would be more vulnerable to a viral attack. However this aspect still needs more work. But it is interesting that two highly iron enriched foods wheat and milk have been linked to type I. </li></ul>Chris YUKNA Science General Ecole des Mines Saint Etienne [email_address]
  8. 8. <ul><li>Chris Yukna </li></ul><ul><li>EMSE </li></ul><ul><li>Science General </li></ul><ul><li>[email_address] </li></ul><ul><li>Sources </li></ul><ul><li>Pancreatic cancer & diabetes </li></ul><ul><li>http://www.molecular-cancer.com/content/2/1/4 </li></ul><ul><li>Low salt diets increase insulin resistance </li></ul><ul><li>http://www.sciencemag.org/content/293/5535/1673.short </li></ul><ul><li>Unfinished </li></ul>Chris YUKNA Science General Ecole des Mines Saint Etienne [email_address]

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