New Investigator (NI) - PD/PI who has not yet competed successfully for a substantial NIH research grant (for multiple PIs, all must meet requirement for NI status).
Early Stage Investigator (ESI) - PD/PI who qualifies as a New Investigator AND is within 10 years of completing their terminal research degree or within 10 years of completing their medical residency (or equivalent).
Overall Impact is not a sixth review criterion and is not necessarily the arithmetic mean of the scores for the scored review criteria. Overall Impact is the synthesis/integration of the five core review criteria that are scored individually along with the additional review criteria which are not scored separately.
Does the project address an important problem or critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Applications reviewed in order of preliminary overall impact scores
Applications with initial scores between 7-9 are unlikely to be discussed
All applications receive criterion scores
Criterion scores are not discussed at review
Score Descriptor Additional Guidance on Strengths/Weaknesses 1 Exceptional Exceptionally strong with essentially no weaknesses 2 Outstanding Extremely strong with negligible weaknesses 3 Excellent Very strong with only some minor weaknesses 4 Very Good Strong but with numerous minor weaknesses 5 Good Strong but with at least one moderate weakness 6 Satisfactory Some strengths but also some moderate weaknesses 7 Fair Some strengths but with at least one major weakness 8 Marginal A few strengths and a few major weaknesses 9 Poor Very few strengths and numerous major weaknesses
Assigned reviewers (typically 3 primary) define the range of scores for each specific application
At the time of the review, scores are provided by all present. Any reviewer who plans to score outside the range established by the assigned (primary) reviewers needs to declare their intention, which is based on their determination of overall impact.
Discussed applications receive an overall score from each eligible (non-conflicted) panel member. Scores are averaged to one decimal place and multiplied by 10. Hence, there are 81 possible priority scores that range from 10 to 90.
Critiques: The Critiques below were prepared by the reviewers assigned to this application. These commentaries do not necessarily reflect the position of the authors at the close of the group discussion, nor the final majority opinion of the group , although reviewers are asked to amend their critiques if their position changed during the discussion. The resume and other initial sections of the summary statement are the authoritative representation of the final outcome of group discussion. If there is any discrepancy between the peer reviewers’ commentaries and the action statement for a given component, or the overall score, the action statement for the component, the overall critique, and the overall numerical score on the face page of this summary statement should be considered the most accurate representation of the final outcome of the group discussion .