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In the past few years JChem for Excel has become an acknowledged data analysis tool mostly in the pharma industry, due to its wide range of integrated functions and customizability. This talk will demonstrate its improved usability focusing on new layouts for filter, search and related processes. Re-organized ribbon sets will also be presented for beginners and advanced users, classified chemical functions with more detailed help descriptions are giving assistance to users to get more familiar with the product. A few one-click solutions facilitate JChem for Excel’s opening to the integration with other Office products.