Summary of
New Products Introduced:
September 9-13, 2013
For more detailed product info visit: https://www.caymanchem.com/...
600870 TAF1 bromodomain 1 TR-FRET Assay Kit
600930 TAF1 bromodomains 1 & 2 TR-FRET Assay Kit
TAF1
• a component of transcr...
700880 p-Aminohippuric Acid (PAH) Assay Kit
colorimetric method for detecting PAH from plasma and urine
used to measure ef...
700910 Catalase Assay Kit (without Hydrogen Peroxide)
this assay utilizes the peroxidatic function of CAT to
determine enz...
14170 MDC1 BRCT domains (human recombinant)
MDC1
• contains two BRCA1 C-terminal (BRCT)
domains, which recognize linear ph...
14701 JARID1B/PLU1 (C-Term) Polyclonal Antibody
Antigen: JARID1B human protein (amino acids
1534-1544) · Host:rabbit · App...
14904 GPR120 (Internal) Polyclonal Antibody
Antigen: human GPR120 amino acids 247-258
(SEITKASRKRLT) · Host:rabbit · Appli...
HMG-CoA reductase inhibitors
10010334 Fluvastatin
• (Ki = 0.3 nM)
• trade name Lescol® for the treatment of hypercholester...
11878 Salicylcurcuminoid
synthetic curcuminoid
antioxidant and anticarcinogenic properties
increases the activity of quino...
14749 Fostriecin (sodium salt)
inhibits serine/threonine protein phosphatases
(PP2A IC50 = 3.2 nM)
(PP4 IC50 = 3 nM)
incre...
sPLA2 inhibitors
14902 Luffariellolide
• reversibly inhibits sPLA2 isoforms from bee venom (IC50 = 230
nM) and snake venom...
14915 Oxymatrine
natural alkaloid isolated from the root of S.
flavescens, an herb used in traditional
Chinese herbal medi...
14916 Protocatechuic Acid
dihydroxybenzoic acid phenolic compound found in many edible
and medicinal plants
major metaboli...
Receptor Antagonists
14914 NBQX (sodium salt)
• AMPA- and kainate-sensitive glutamate receptor antagonist
• (IC50 = 0.15 a...
14962 Ryanodine
poisonous alkaloid found in the South American plant R. speciosa
prototypical ligand for ryanodine recepto...
14963 Tetrodotoxin
potent marine-derived neurotoxin that reversibly inhibits the
inward sodium current through voltage-act...
Dyes and Indicators
14919 XTT (sodium salt)
• cell-impermeable, negatively charged tetrazolium dye that produces a
water-s...
New Forensic Products
14292 ADB-FUBINACA
designer drug identified in synthetic cannabis blends in Japan in 2013
14897 N-me...
Upcoming SlideShare
Loading in …5
×

New Cayman Chemical Products - Sept 17th, 2013

787 views

Published on

Cayman Chemical: Weekly report of new products highlighting some key features of each...

Published in: Health & Medicine, Technology
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
787
On SlideShare
0
From Embeds
0
Number of Embeds
305
Actions
Shares
0
Downloads
3
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

New Cayman Chemical Products - Sept 17th, 2013

  1. 1. Summary of New Products Introduced: September 9-13, 2013 For more detailed product info visit: https://www.caymanchem.com/NewProducts
  2. 2. 600870 TAF1 bromodomain 1 TR-FRET Assay Kit 600930 TAF1 bromodomains 1 & 2 TR-FRET Assay Kit TAF1 • a component of transcription factor IID • interacts with transcriptional activators to promote transcription • Recognition of acetylated lysine residues via its two bromodomains directs TAF1 binding to the core promoter sequences at the transcription start site •homogeneous TR-FRET assay method • rapid characterization of inhibitors of bromodomain/acetylated peptide interaction •amenable to high throughput format robust, Z’ >0.6 384 wells $495 1920 wells $1,856 9600 wells $8,313
  3. 3. 700880 p-Aminohippuric Acid (PAH) Assay Kit colorimetric method for detecting PAH from plasma and urine used to measure effective renal plasma flow (eRPF) At low doses, PAH is almost completely eliminated from the blood during a single pass through the kidney also be used to measure net tubular organic anion secretion Uptake of PAH from blood into the tubular cells occurs by exchange with intracellular α- ketoglutarate and is mediated by the organic anion transporter 1 96 wells $295 image credit: http://droualb.faculty.mjc.edu/Course%20Materials/Physiology%20101/Chapter%20Notes/Fall%202011/chapter_18%20Fall%202011.htm
  4. 4. 700910 Catalase Assay Kit (without Hydrogen Peroxide) this assay utilizes the peroxidatic function of CAT to determine enzyme activity in plasma, serum, erythrocyte lysates, tissue homogenates, and cell lysates Catalase (CAT) • ubiquitous antioxidant enzyme involved in the detoxification of hydrogen peroxide (H2O2), a toxic product of both normal aerobic metabolism and pathogenic ROS production • catalyzes the conversion of two molecules of H2O2 to molecular oxygen and two molecules of water (catalytic activity) • demonstrates peroxidatic activity, in which low molecular weight alcohols can serve as electron donors 96 wells $270 480 wells $490 2H2O2 2H2O + O2 catalase
  5. 5. 14170 MDC1 BRCT domains (human recombinant) MDC1 • contains two BRCA1 C-terminal (BRCT) domains, which recognize linear phosphoserine or phosphothreonine regions to mediate protein- protein and protein-DNA interactions C-terminal BRCT domains of MDC1 recognize phosphorylated histone H2AX (γH2AX), a marker of DNA damage binds to and retains the Mre11-Rad50-Nbs1 complex at sites of double-stranded breaks in DNA serves as a scaffold for a DNA repair locus which attracts BRCA1 and 53BP1 to effect DNA repair by either non-homologous end-joining or homologous recombination 25 µg $125 50 µg $198 100 µg $374
  6. 6. 14701 JARID1B/PLU1 (C-Term) Polyclonal Antibody Antigen: JARID1B human protein (amino acids 1534-1544) · Host:rabbit · Application(s): FC and ICC · Jumonji AT-Rich Interactive Domain 1B nuclear protein that is a potential histone demethylase JARID1B demethylation of Lys-4 of histone H3 plays an important role in breast cancer cell proliferation through BRCA1 repression also acts as a transcriptional co-repressor of two developmental transcription factors, PAX-9 and BF1, which are crucial for organogenesis 1 ea $229
  7. 7. 14904 GPR120 (Internal) Polyclonal Antibody Antigen: human GPR120 amino acids 247-258 (SEITKASRKRLT) · Host:rabbit · Application(s): ELISA and WB · A G protein-coupled receptor expressed in adipocytes and pro- inflammatory macrophages activated by long chain free fatty acids activation results in elevated Ca2+ and activation of the ERK cascade ω-3 fatty acids initiate GPR120 signaling resulting in anti- inflammatory effects indirectly involved with promoting insulin secretion 1 ea $229 Image credit: Cell, Volume 142, Issue 5, 687-698, 3 September 2010
  8. 8. HMG-CoA reductase inhibitors 10010334 Fluvastatin • (Ki = 0.3 nM) • trade name Lescol® for the treatment of hypercholesterolemia in the prevention of cardiovascular disease • reduced LDL cholesterol levels by 27% after six weeks of treatment with a dose of 40 mg/kg twice a day compared to placebo in clinical trial 10010342 Pravastatin • (Ki = 2.3 nM) • a ring hydroxylated metabolite of mevastatin • marketed as Pravachol™ or Lipostat™ for reducing LDL cholesterol and triglyceride levels and increasing HDL cholesterol in the prevention of cardiovascular disease 10 mg $29 25 mg $65 50 mg $109 100 mg $189 10 mg $29 25 mg $65 50 mg $109 100 mg $189
  9. 9. 11878 Salicylcurcuminoid synthetic curcuminoid antioxidant and anticarcinogenic properties increases the activity of quinone reductase in mouse hepatoma cells in a dose-dependent fashion 1 mg $39 5 mg $176 10 mg $312 See also: 81025 Curcumin 81025.1 Curcumin (technical grade) 10960 Bisdemethoxycurcumin 10961 Demethoxycurcumin 10009986 Dimethoxycurcumin 14451 J 147 11879 2-HBA Image credit: http://www.dallasnews.com/lifestyles/health-and-fitness/health/20110815-researchers-call-curcumin-solid-gold-for-its-curative-properties.ece
  10. 10. 14749 Fostriecin (sodium salt) inhibits serine/threonine protein phosphatases (PP2A IC50 = 3.2 nM) (PP4 IC50 = 3 nM) increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation first identified as an antitumor antibiotic 10 µg $145 Image credit: Molecular Cell Volume 41, Issue 6, 18 March 2011, Pages 636–648
  11. 11. sPLA2 inhibitors 14902 Luffariellolide • reversibly inhibits sPLA2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation • blocks the production of PAF in stimulated neutrophils (IC50 = 5 μM) • structural mimic of all-trans retinoic acid (RA) • In RA-sensitive cancer cell lines, induces the expression of RAR target genes and inhibits cell growth 14903 Manoalide • irreversibly inhibits sPLA2 isoforms from human synovium, bee venom, and cobra venom (IC50 = 3.9, 7.5, and 2 μM, respectively) • potently blocks calcium channels (IC50 = 1 μM) • inhibits phospholipase C (IC50 = 1.5 μM) 1 mg $120 1 mg $160
  12. 12. 14915 Oxymatrine natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine antiviral properties = inhibits the replication of hepatitis B prevents fibrosis in a number of organs including liver, by interfering with TGF-β signaling induces apoptosis in certain cancer cells ameliorates inflammation by impairing the translocation of NF-κB 50 mg $39 100 mg $66 500 mg $137 1 g $195 Image credit: http://en.wikipedia.org/wiki/File:Sophora_flavescens.jpg
  13. 13. 14916 Protocatechuic Acid dihydroxybenzoic acid phenolic compound found in many edible and medicinal plants major metabolite of antioxidant polyphenols found in green tea free radical scavenging capability (IC50 = 16.3 μM) anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities 25 g $35 50 g $63 100 g $112
  14. 14. Receptor Antagonists 14914 NBQX (sodium salt) • AMPA- and kainate-sensitive glutamate receptor antagonist • (IC50 = 0.15 and 4.8 µM, respectively) • does not block the NMDA-sensitive glutamate receptor (IC50 > 90 µM) 14959 CTAP • selective µ opioid receptor antagonist (IC50 = 3.5 nM) • 10-fold more potent than naltrexone as an antagonist of diverse compounds with antinociceptive effects through the µ opioid receptor • resists enzymatic metabolism in the blood and passes the BBB 1 mg $45 10 mg $158 50 mg $675 1 mg $79
  15. 15. 14962 Ryanodine poisonous alkaloid found in the South American plant R. speciosa prototypical ligand for ryanodine receptors, a family of calcium release channels located in skeletal and cardiac muscle used as a potent organic insecticide specific against crop-damaging insects investigative tool for identifying the various ryanodine receptor isoforms and characterizing their role in calcium signaling 1 mg $125 •nanomolar concentrations increases the calcium permeability of sarcoplasmic reticulum membranes leading to muscular contractions •micromolar (~100 μM) concentrations irreversibly inhibit ryanodine receptor channel opening, which results in paralysis Image credit: http://www.cs.stedwards.edu/chem/Chemistry/CHEM43/CHEM43/Ryanodine/RyRproject.html
  16. 16. 14963 Tetrodotoxin potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels blocks nerve and muscle action potentials used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials indispensible neuroscience tool to pharmacologically dissect the contribution of the NaV current in excitable neurons used to rationally design compounds for the treatment of neuropathic pain 14964 Tetrodotoxin Citrate = citrate-stabilized form designed better solubility 1 mg $135 1 mg $145 Image credit: http://commons.wikimedia.org/wiki/File:Poisson-lune.jpg
  17. 17. Dyes and Indicators 14919 XTT (sodium salt) • cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular- derived NADH and an electron mediator • frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis 14960 Fluo 3AM • acetoxymethyl (AM) ester of Fluo 3, a fluorescent calcium indicator commonly used in flow cytometry and cell-based experiments to detect changes in intracellular levels • cell permeable and readily taken up by living cells, whereupon the AM moiety is enzymatically removed to produce Fluo 3 25 mg $39 50 mg $62 100 mg $101 250 mg $215 500 µg $155 1 mg $248
  18. 18. New Forensic Products 14292 ADB-FUBINACA designer drug identified in synthetic cannabis blends in Japan in 2013 14897 N-methyl-2-AI (hydrochloride) novel aminoindane with potential for abuse Deuterated Standards for RCS-4 (synthetic JWH 018 cannabinoid analog) metabolites: 14363 RCS-4 N-(4-hydroxypentyl) metabolite-d5 14364 RCS-4 N-(5-hydroxypentyl) metabolite-d5 14365 RCS-4 N-pentanoic acid metabolite-d5

×