EWMA 2013 - Ep541 - VALUE OF A SKIN CREAM WITH HYPEROXYGENATED ESSENTIAL FATTY ACIDS IN THE TREATMENT OF HAND-FOOT SYNDROME (HFS)

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C. LLAMBRICH MOLINES, A.S. BOUNIE, C. CHASSAING and R. D’ARGOUGES, M. MARTIN

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EWMA 2013 - Ep541 - VALUE OF A SKIN CREAM WITH HYPEROXYGENATED ESSENTIAL FATTY ACIDS IN THE TREATMENT OF HAND-FOOT SYNDROME (HFS)

  1. 1. VALUE OF A SKIN CREAM WITH HYPEROXYGENATED ESSENTIAL FATTY ACIDS IN THE TREATMENT OF HAND-FOOT SYNDROME (HFS) C. LLAMBRICH MOLINES, A.S. BOUNIE, C. CHASSAING and R. D’ARGOUGES(1) M. MARTIN (2) (1) CISCO Team*, France (2) Laboratoires URGO, Chenôve, France * Emmanuelle Picaud, Tiffany Hubault, Armelle Bichet, Marine Jehl *Brand name: the skin cream is UrgoRepair®
  2. 2. Hand-foot syndrome (HFS or Palmar-Plantar Erythrodysesthesia) is one of the side effects of oral chemotherapy (capecitabin (Xeloda®). It is characterised by palmar-plantar erythema, which may progress to scaling and ulceration, sometimes painful and with functional repercussions. These skin lesions are classified according to 3 grades. The treatment of HFS is not subject to any particular protocol and remains based on local treatments (such as moisturising creams) and/or adjustment of the chemotherapy dosage. The cream emulsion* (hyperoxygenated essential fatty acid glycerides) moisturises and repairs the skin. INTRODUCTION *Brand name: the cream emulsion is UrgoRepair®
  3. 3. OBJECTIVE To assess the efficacy of the cream emulsion* in HFS (Hand-Foot Syndrome) in breast cancer patients. *Brand name: the cream emulsion is UrgoRepair®
  4. 4. METHODOLOGY As part of CISCO nursing consultations at the Outpatient Chemotherapy Clinic (Institut Curie, Paris): • Inclusion of patients treated with capecitabin and presenting grade 1 or 2 HFS (Hand-Foot Syndrome) • Initiation of the cream emulsion* treatment at an initial visit (D0) • Cream emulsion* treatment duration of 6 to 9 weeks • A clinical, photographic and quality- of-life assessment (EQ-5D descriptive scale) was documented at each visit. D0: Presence of erythema on the inner surface of the hand D56: Disappearance of erythema *Brand name: the cream emulsion is UrgoRepair®
  5. 5. RESULTS 25 women with breast cancer treated with capecitabin: • Hands: mostly grade 1 HFS (Hand-Foot Syndrome) • Feet: mostly grade 2 HFS Average age: 64 years (range: 48 - 86 years) Average follow-up period = 49.5 days (median 43 days). Three patients were not seen again for the final visit. The cream emulsion* was applied 2 to 4 times daily in the majority of cases. D0: Presence of hyperkeratosis, skin cracks and erythema D63: Alleviation of symptoms following treatment with the cream emulsion *Brand name: the cream emulsion is UrgoRepair®
  6. 6. All the symptoms of HFS (Hand-Foot Syndrome) demonstrated an improvement following application of this cream, particularly signs such as hyperkeratosis, skin cracks and erythema. RESULTS
  7. 7. RESULTS This reduction in chemotherapy-related side effects is accompanied by an improvement in Quality of Life, particularly in terms of pain:
  8. 8. The patients noted an overall improvement in their quality of life between the initial visit and the final visit. Improvement of 10 points compared to median VAS** score. At the end of follow-up, almost 60% of the patients considered that their HFS symptoms had improved from the second week of application (18.2% of whom after less than a week). No worsening of HFS was reported. No local adverse effects related to the cream were observed during follow-up ** VAS = Visual Analogue Scale RESULTS
  9. 9. CONCLUSION The cream emulsion*, combined with regular nursing and medical follow-up and patient education, offers genuine benefits for the local management of Hand-foot syndrome and appears to improve patients' quality of life. Applied to the hands and feet, the cream emulsion* corrects dry skin and promotes the healing of superficial trophic disorders of the skin. *Brand name: the cream emulsion is UrgoRepair®
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