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Canada peptide.com ppt the strategy of peptide synthesis
1. The Strategy of Peptide Synthesis
• Making peptide bonds between two or more
amino acids is not difficult, especially for
biochemists and science enthusiasts.
• The tricky part though is, connecting these
amino acids in the correct sequence which
may not be easy.
3. The Definition
• In organic chemistry, peptide synthesis is defined
as the production of organic compounds (or
peptides) in which amino acid chains are linked
together by amine bonds or peptide bonds.
• Peptides are synthesized by linking the carboxyl
group of one amino acid (or linking the C-
terminal end) to either the C-terminus or N-
terminus of another amino acid. Basically,
peptide synthesis starts at the C-terminal end of a
peptide and ends at the N-terminus of another.
4. The synthesis process
• There are two phases of
peptide synthesis
namely;
• The liquid phase
synthesis
• The solid phase
synthesis
5. The liquid Phase Synthesis
• This is more like a traditional approach to
peptide synthesis.
• As much as it is a classical method, it is used
for large scale peptide productions for
industrial purposes.
6. The Solid Phase Synthesis
• This approach has replaced the traditional
liquid phase synthesis.
• Over the years, this method has shown a shift
within the peptide synthesis community, and
has now become the standard method for
synthesizing peptides and proteins.