EORTC Virtual Tumor Bank (VTB)
<ul><li>Tumor Bank Steering Committee, which is  composed of representatives of the EORTC Pathology Group and EORTC Data C...
EORTC Tumor Bank - Aims <ul><li>To standardize and support histology review across  EORTC trials (quality of research) </l...
Histology review Tumor banking Translational research Virtual tumour bank and  real tumour bank
Glass Slides Paraffin Embedded Tissue Blocks Real Tumor Bank (EORTC Data Center)
Material and Data Flowchart during histology review
Support for Translational Research within EORTC protocols
Patient information Sheet/Informed consent (PIS/IC) <ul><li>in case of  optional  research on biological material  separat...
Virtual Tumor Bank (VTB) - Goals <ul><li>Design and construction of a pathology database for pathology and material data a...
Virtual slides can be produced from the glass slides collected and stored with the tissue records within the VTB.  This wi...
Panel Review  (if required) Panel Member (PM) Panel Chairperson (PC) Panel Member (PM) Panel Member (PM) VTB  System VISTA...
Current Tumor Bank Project supported trials/groups <ul><li>GU Group (30993 + 30994) </li></ul><ul><li>Gynecological  Cance...
Future hopes and goals for the EORTC Tumor Bank and TuBaFrost <ul><li>Short Term: </li></ul><ul><li>use the VTB for centra...
Screenshots of the Virtual Tumor Bank (VTB) System
 
 
 
 
 
 
 
EORTC Tumor Bank Website:   www.eortc.be/vtb/tumorbank
Upcoming SlideShare
Loading in...5
×

Virtual Tumor Bank (VTB) System

764

Published on

Published in: Economy & Finance, Business
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
764
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
8
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide
  • The steering committee is made up of members from the EORTC Pathology group and EORTC Data center. The EORTC Tumor Bank is also supported by the EORTC IT unit and number of other EORTC committees (executive, TRAC, TRU, laboratory division etc..).
  • Aims of the TB: create a centralized tumor bank of glass slides (stained+unstained) and paraffin blocks. This physical tumor bank together with a virtual bank (online access to information about material, images, diagnostic data and clinical data and search engine) allows the tumor bank to standardize and improve histology review as well as support translational research (access to online information and material). Rules and access for use of tissue (in and between the different EU states) will be investigated as well as legal issues concerning patient informed consent for use of material for research.
  • The Real and Virtual Tumor Bank will support both histology review and translational research within EORTC protocols.
  • One of task of the project is to create a centralized (at the EORTC data center) tumor bank of glass slides (stained+unstained) and paraffin blocks.
  • During Histology review supported by the EORTC Tumor Bank, the EORTC Tumor Bank Office will request pathology forms, reports and material from local pathologists and will send to the review pathologists for pathology review. This way the EORTC Tumor Bank acts as a central management tool for histology review in EORTC clinical trials. It will also be the role of a pathologist (most cases review pathologist) to digitize images from the glass slides and upload them into the patient case ONLINE. In the future this will also, hopefully, be supported by a virtual microscope system installed at the EORTC Data Center.
  • A researcher will be able to access the VTB search online and search for material of interest to his/her project. They can then make requests for the material (via translational research project applications) and the EORTC Tumor Bank will organize the collection and sending of the relevant material from the EORTC Data Center (if centrally stored) or the original pathology labs (if locally stored). The EORTC Tumor Bank will also be responsible for returning the left over material after the research has been conducted on the material.
  • One of the tasks of the project was to develop a Patient Information sheet/Informed consent that would allow patients to consent to use of their biological material for research purposes. Two such types of PIS/IC were developed: one for optional research on biological material and one for mandatory research on biological material.
  • Goals of the Virtual Tumor Bank (VTB): 1. design and construct a pathology database in order to collect pathology and tissue material data (stored either centrally at the EORTC or locally in pathology labs) and link this database to the EORTC VISTA clinical database. 2. Construct a website (VTB system) to allow users (pathologists and researchers) to access anonymized patient data (pathology, clinical and tissue material data) online to support histopathology review. 3. Construct an online search engine available to researchers to search for tissue material and data that would be of interest to their research projects.
  • Virtual slides can be produced from the glass slides collected and stored with the tissue records within the VTB. This will support histology review and provide further assistance to researchers.
  • Pathology Panel review can also take place through the VTB website which allows panel members to access the clinical and diagnostic data as well as the images associated with a patient case. They can then submit their individual diagnoses of the patient case directly via the VTB website online. A panel chairperson is then allocated to make the final consensus panel diagnosis of the case.
  • These are the current EORTC disease-orientated groups that our involved in the Tumor Bank Project. The Tumor Bank unit is either supported them through central histology review, translational research or both.
  • Screenshots of the Virtual Tumor Bank System will follow.
  • Once a user (participating in a study) logs into the VTB system he will select the study and be presented with a list of patient cases which he can select.
  • He/she will be then presented with a ‘Patient Case Record’ containing clinical data, material information, and diagnostic data.
  • The user will also be able to view the virtual and representative slide images associated with material collected for the case.
  • Clicking on a image will allow the user to further view the images at higher magnification.
  • Pathologists involved in the case will also be able to upload their own representative images into the patient case.
  • Panel committee pathologists will be able to submit their own diagnosis for a particular case.
  • Researchers will be able to access an online search engine to find material of interest to their research projects.
  • This is the web link for the official EORTC Tumor Bank project website where there is also a link to a demonstration of the VTB system.
  • Virtual Tumor Bank (VTB) System

    1. 1. EORTC Virtual Tumor Bank (VTB)
    2. 2. <ul><li>Tumor Bank Steering Committee, which is composed of representatives of the EORTC Pathology Group and EORTC Data Center: </li></ul><ul><ul><ul><li>Wolter Oosterhuis, EORTC Tumor Bank, chairman </li></ul></ul></ul><ul><ul><ul><li>Alain Spatz, EORTC Pathology group, chairman </li></ul></ul></ul><ul><ul><ul><li>King Lam, EORTC Pathology sub-committee group for Telematics, chairman </li></ul></ul></ul><ul><ul><ul><li>Peter Riegman, pathologist and assistant project leader of the TuBaFrost Project, Erasmus Medical Center, Rotterdam </li></ul></ul></ul><ul><ul><ul><li>Ivana Teodorovic, EORTC Tumor Bank Coordinator, EORTC Data Center </li></ul></ul></ul><ul><ul><ul><li>Martin Isabelle, EORTC Tumor Bank Administrator (TBA), EORTC Data Center </li></ul></ul></ul><ul><li>EORTC IT unit (Pascal Ruyskart, Yves Dohogne and Eric Decossaux) </li></ul><ul><li>EORTC Legal Advisor </li></ul><ul><li>Pilot phase project sponsored by Parthenon Trust (Sept 2000- Sept 2003) </li></ul>EORTC Tumor Bank
    3. 3. EORTC Tumor Bank - Aims <ul><li>To standardize and support histology review across EORTC trials (quality of research) </li></ul><ul><li>Create tumor bank </li></ul><ul><ul><li>Real tumor bank (centralized storage of paraffin embedded tissue blocks and glass slides [stained/unstained] at the EORTC Data Center) </li></ul></ul><ul><ul><li>Virtual tumor bank (information and histological images on centralized and decentralized stored material) </li></ul></ul><ul><ul><li>Legal issues </li></ul></ul><ul><ul><li>Access and use </li></ul></ul><ul><li>Facilitate translational research (by making biological material available to scientists) </li></ul>
    4. 4. Histology review Tumor banking Translational research Virtual tumour bank and real tumour bank
    5. 5. Glass Slides Paraffin Embedded Tissue Blocks Real Tumor Bank (EORTC Data Center)
    6. 6. Material and Data Flowchart during histology review
    7. 7. Support for Translational Research within EORTC protocols
    8. 8. Patient information Sheet/Informed consent (PIS/IC) <ul><li>in case of optional research on biological material separate documents for clinical PIS/IC and the one related to translational research </li></ul><ul><li>in case of mandatory research on biological material within a clinical trial, only one PIS/IC covering both aspects </li></ul><ul><li>explanation about research on biological material must be clear and transparent and should include: </li></ul><ul><ul><li>information about possibility to reveal any kind of hereditary nature of disease </li></ul></ul><ul><ul><li>protection of patient rights and identity </li></ul></ul><ul><ul><li>benefits for research </li></ul></ul><ul><ul><li>voluntary aspects </li></ul></ul><ul><ul><ul><li>in case of optional research </li></ul></ul></ul><ul><ul><ul><li>in using material for future cancer research </li></ul></ul></ul><ul><ul><ul><li>on sending the material to a third party </li></ul></ul></ul><ul><ul><li>agreement for an additional tissue sampling </li></ul></ul><ul><ul><li>explanation about intellectual property rights </li></ul></ul>
    9. 9. Virtual Tumor Bank (VTB) - Goals <ul><li>Design and construction of a pathology database for pathology and material data and a link to the EORTC clinical database </li></ul><ul><li>Construction of a website (Virtual Tumor Bank) to allow users to access patient's pathology, clinical and material (including images) data online and allow online pathology review to take place. </li></ul><ul><li>Construction of an online search engine to allow researchers to search for tissue material, view tissue information (including images) and check on tissue availability for their research projects. </li></ul>
    10. 10. Virtual slides can be produced from the glass slides collected and stored with the tissue records within the VTB. This will support histology review and provide further assistance to researchers.
    11. 11. Panel Review (if required) Panel Member (PM) Panel Chairperson (PC) Panel Member (PM) Panel Member (PM) VTB System VISTA DATABASE VTB DATABASE Virtual Tumor Bank
    12. 12. Current Tumor Bank Project supported trials/groups <ul><li>GU Group (30993 + 30994) </li></ul><ul><li>Gynecological Cancer Group (55994 and 55012) </li></ul><ul><li>GI Group </li></ul><ul><li>STBSG Group (62005) </li></ul>
    13. 13. Future hopes and goals for the EORTC Tumor Bank and TuBaFrost <ul><li>Short Term: </li></ul><ul><li>use the VTB for central access to decentralised collections of frozen tissues in further EORTC-affiliated institutions </li></ul><ul><li>prospectively collect paraffin blocks of all patients entered in an EORTC trials </li></ul><ul><li>make the existing collections of material available to investigators for translational research </li></ul><ul><li>engage EORTC-affiliated OECI institutions in building up collections of frozen tissues of patients entered in EORTC trials </li></ul><ul><li>submit a follow up project for TuBaFrost in the 6FP in collaboration with the OECI </li></ul><ul><li>select one Pathology Lab to do the lab work for the Tumor Bank at the DC; the lab of Erasmus MC would be a good candidate in view of its current role in the VTB and the TuBaFrost Project </li></ul><ul><li>set up a Charitable Trust in collaboration with the OECI </li></ul><ul><li>Long Term: </li></ul><ul><li>purchase a machine to make tissue micro-arrays at the DC and make virtual slides of tissue micro-arrays and of the experimental results obtained with them </li></ul><ul><li>create a small lab at the DC for cutting paraffin blocks and staining slides with H and E </li></ul><ul><li>make tissues available to the research community and the private sector through the Charitable Trust, on a not-for-profit basis </li></ul>
    14. 14. Screenshots of the Virtual Tumor Bank (VTB) System
    15. 22. EORTC Tumor Bank Website: www.eortc.be/vtb/tumorbank
    1. A particular slide catching your eye?

      Clipping is a handy way to collect important slides you want to go back to later.

    ×