“Attacking the Driver of Increased     Stroke, Heart Disease, and Diabetes”                         Invited Talk       Rig...
During the Last 15 Years, the Fraction of the Population         That is Obese Has Greatly Increased                    So...
Over 1/3 of American Adults are Obese:    This is the Driver of Increased Disease Obesity-related conditions include heart...
I Arrived in La Jolla in 2000 After 20 Years in the Midwest      and Decided to Move Against the Obesity Trend            ...
The Body’s Glucose-Insulin CycleIs at the Heart of Why We Get Fat           “Carbohydrate is            driving insulin is...
Is Government and Medical Advice   Driving the Obesity Epidemic?                        The Low-Carb Alternative  Avoid Hi...
Intermediate Moments    On the Path to Public Health    2012                       1982Glycemic Index:•Potato 126•Table Su...
Reversing the Consumption of High GlycemicSweeteners is Key to Reducing Public Health Risks
I Modified My Diet to Reduce Calories, Sugar,     and Sodium, While Increasing Fiber
Statins Do Change Your Cholesterol LevelsBy Lowering LDL, Thus Lowering Total Cholesterol                                 ...
But What About Fat? Inflammation Is DrivenBy Consuming Excess Omega-6 Essential Fatty Acids                     2004
I Lowered My Body’s Inflammation Driven by Food By Increasing Omega-3s and Reducing Omega-6s                              ...
Goal: Increase My Omega-3 Scores By Diet Changes         To Protect Against Future Heart Disease                          ...
Lower Triglycerides by Increasing Omega-3 Intake    and by Reducing Foods High in Refined Carbs• TG  – High Risk 200-500  ...
New Meta-Analysis Shows Why             Low-Carb Diets Lower Heart Disease Risk     Tian Hu, et al., Tulane University Sch...
mobile   socialSMART             Social Mobile Approach to Reduce Weight                  Source: Kevin Patrick, UCSD SOM ...
Exercise Lowers Risk of Heart Disease and Diabetes     “Weight training was associated with a significantly lower risk of ...
The Biofeedback of Monitoring Enables Me             To Increase My Daily Caloric Burnwww.bodymedia.com                   ...
FitBit Compares Your Stepsto Population of Your Age and Sex
Goal: Use Strength Trainingto Raise My Rest Metabolic Rate                                        3x     Source: Terry Mar...
LS Resting Heart RateYear                  Resting Heart Rate2000                           602005                        ...
Another Example of the Efficacy of Aerobic Exercise            on Lowering Heart Rate            Data from Rajesh Gupta, C...
Blood Pressure Home Monitoring Problem:    Wide Scatter in Results Over Time             LS Feb-March 2010             40m...
Change in LS Blood Pressure Under Different Blood Pressure MedicationsYear       Blood         Average      Average       ...
Quantifying My Sleep Pattern Using a Zeo - Increased My Average to 8 Hours/Night          Stroke risk increased by sleepin...
Challenge-Coupling Personal Sensor Data         With Social Networks Across Private Clouds                                ...
Invited Paper for Focus Issue of Biotechnology Journal,    Edited by Profs. Leroy Hood and Charles Auffray.       Download...
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Attacking the Driver of Increased Stroke, Heart Disease, and Diabetes

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12.11.05
Invited Talk
Right Care Rotating University of Best Practices
Title: Attacking the Driver of Increased Stroke, Heart Disease, and Diabetes
UCSD

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Attacking the Driver of Increased Stroke, Heart Disease, and Diabetes

  1. 1. “Attacking the Driver of Increased Stroke, Heart Disease, and Diabetes” Invited Talk Right Care Rotating University of Best Practices UCSD November 5, 2012 Dr. Larry SmarrDirector, California Institute for Telecommunications and Information Technology Harry E. Gruber Professor, Dept. of Computer Science and Engineering 1 Jacobs School of Engineering, UCSD
  2. 2. During the Last 15 Years, the Fraction of the Population That is Obese Has Greatly Increased Source: Behavioral Risk Factor Surveillance System, CDC (Obese is BMI ≥30, or ~ 30 lbs. overweightfor 5’ 4” person)
  3. 3. Over 1/3 of American Adults are Obese: This is the Driver of Increased Disease Obesity-related conditions include heart disease,stroke, type 2 diabetes and certain types of cancer, some of the leading causes of preventable death. --CDC www.cdc.gov/obesity/data/adult.html
  4. 4. I Arrived in La Jolla in 2000 After 20 Years in the Midwest and Decided to Move Against the Obesity Trend 1999 2010 2000 Age Age 51 61 I Reversed My Body’s Decline By Altering Nutrition and Exercise
  5. 5. The Body’s Glucose-Insulin CycleIs at the Heart of Why We Get Fat “Carbohydrate is driving insulin is driving fat,” the late George Cahill, formerly at Harvard Medical School.
  6. 6. Is Government and Medical Advice Driving the Obesity Epidemic? The Low-Carb Alternative Avoid High Glycemic Carbs Which Spike Your Glucose-Insulin Cycle
  7. 7. Intermediate Moments On the Path to Public Health 2012 1982Glycemic Index:•Potato 126•Table Sugar 97
  8. 8. Reversing the Consumption of High GlycemicSweeteners is Key to Reducing Public Health Risks
  9. 9. I Modified My Diet to Reduce Calories, Sugar, and Sodium, While Increasing Fiber
  10. 10. Statins Do Change Your Cholesterol LevelsBy Lowering LDL, Thus Lowering Total Cholesterol Began Statin I am Currently on 5mg Crestor Daily
  11. 11. But What About Fat? Inflammation Is DrivenBy Consuming Excess Omega-6 Essential Fatty Acids 2004
  12. 12. I Lowered My Body’s Inflammation Driven by Food By Increasing Omega-3s and Reducing Omega-6s “Silent Inflammation” Chronically Ill I take 6 Fish Oil American Pills Per Day Average “Healthy” American Blood Ratio of Omega 6 to Omega 3 Ideal Range My Range Range Source: Barry Sears My Tests by www.yourfuturehealth.com
  13. 13. Goal: Increase My Omega-3 Scores By Diet Changes To Protect Against Future Heart Disease Graphics from www.anne-marie.ca/ratiokits/If your Omega-3 Scoreis at least 7.2 and your DHA Score is at least 4.5, you are 32% less likely todevelop heart disease If your EPA+DHA Score is at least 4.6, you are 70% lesslikely of dying from a heart attack. = My Values Tested by yourfuturehealth.com Ref: Based on Lemaitre et al., n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. Am. J. Clin. Nutr. 77:319-325 (2003).
  14. 14. Lower Triglycerides by Increasing Omega-3 Intake and by Reducing Foods High in Refined Carbs• TG – High Risk 200-500 – Best <150 – My TG Dropped from 62 (2001) to 37 (2012)• TG/HDL – Ratio >4 Are Pre-Diabetic or Have Type 2 Diabetes – Average American Has a Ratio of ~3.3 – My Ratio 0.6 Is Half What is Was in 2001 “The Ratio of Triglycerides to HDL Cholesterol (TG/HDL-C) is the Single Most Powerful Lipid Predictor of Extensive Coronary Disease.” [Clinics 63, 427-432 (2008)]
  15. 15. New Meta-Analysis Shows Why Low-Carb Diets Lower Heart Disease Risk Tian Hu, et al., Tulane University School of Public Health and Tropical Medicine Am J Epidemiol. 2012;176(Suppl):S44–S54“Compared with participants on low-fat diets, persons on low-carbohydrate diets experienced a slightly but statistically significantly lower reduction in total cholesterol, and LDL, but a greater increase in HDL and a greater decrease in triglycerides.” TG Down, HDL Up  TG/HDL Much Lower
  16. 16. mobile socialSMART Social Mobile Approach to Reduce Weight Source: Kevin Patrick, UCSD SOM & Calit2PURPOSETo leverage social networks, social media, mobile phones, and theweb for weight loss among 18-35 year old young adults.Funded with a 5-year grant from NHLBI/NIH
  17. 17. Exercise Lowers Risk of Heart Disease and Diabetes “Weight training was associated with a significantly lower risk of Type 2 Diabetes, independent of aerobic exercise.Combined weight training and aerobic exercise conferred a greater benefit.”
  18. 18. The Biofeedback of Monitoring Enables Me To Increase My Daily Caloric Burnwww.bodymedia.com Elliptical Gardening Up and Down House Steps 25 Week Average: 2473 Calories Burned/Day 1:19 hr Physical Activity/Day (>3 METs) 6887 Steps/Day (~3.4 Miles) Now Using Fitbit Average 8000 Steps/Day
  19. 19. FitBit Compares Your Stepsto Population of Your Age and Sex
  20. 20. Goal: Use Strength Trainingto Raise My Rest Metabolic Rate 3x Source: Terry Martin, LS Trainer
  21. 21. LS Resting Heart RateYear Resting Heart Rate2000 602005 502010 452012 40
  22. 22. Another Example of the Efficacy of Aerobic Exercise on Lowering Heart Rate Data from Rajesh Gupta, Chair CSE, UCSD
  23. 23. Blood Pressure Home Monitoring Problem: Wide Scatter in Results Over Time LS Feb-March 2010 40mg Benicar Daily
  24. 24. Change in LS Blood Pressure Under Different Blood Pressure MedicationsYear Blood Average Average Pressure Systolic Diastolic Drug2010 Benecar 134 73 20mg2012 Losartan 143 82 100mg2012 Lotrel 125 70 5/10mg combo
  25. 25. Quantifying My Sleep Pattern Using a Zeo - Increased My Average to 8 Hours/Night Stroke risk increased by sleeping less than six hours a night -M. Ruiter, Sleep 2012 REM is Normally 20% of Sleep An Infant Typically Mine is Between 45-65% of Sleep Has 50% REM
  26. 26. Challenge-Coupling Personal Sensor Data With Social Networks Across Private Clouds Withing/iPhone- Blood Pressure Body Media- Calories Burned Lose It-Calories Ingested EM Wave PC- Stress Azumio-Heart Rate Zeo-Sleep
  27. 27. Invited Paper for Focus Issue of Biotechnology Journal, Edited by Profs. Leroy Hood and Charles Auffray. Download Pdfs from my Portal:http://lsmarr.calit2.net/repository/Biotech_J._LS_published_article.pdfhttp://lsmarr.calit2.net/repository/Biotech_J._Supporting_Info_published.pdf

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