DNA-Guided Medicine                                              15 September 2011Why are We Investing in Personalized Med...
Genomas OverviewBringing DNA-Guided Medicine to Healthcare Today Genomas has developed and is marketing a unique biomedica...
Hartford Hosp., IOL, CLP, THOCC, UPRGenomas Partners in DNA-Guided Medicine        Biotechnology                  DNA-Guid...
Genetic Prescription System: Drug GPSPhyzioType Systems + DNA-Guided Medicine            PHYZIOTYPE         S Y S T E M S ...
PhyzioType SystemsMedical Device for DNA-Guided Medicine          PHYZIOTYPE        S Y S T E M S                         ...
LPH Laboratory of Personalized HealthClinical Lab, Commercial Launchpad    Pioneering high complexity              LABORA...
LPH Laboratory of Personalized HealthClinical Lab, Commercial Launchpad                               CLP Patient         ...
PHP Personalized Health PortalDecision Support for Clinical Practice                         M.D.                         ...
DRUG SELECTION TABLE: 80 BrandsANTIDEPRESSANTS: Generic (Brand) & Drug Selection                                          ...
HILOmet PhyzioType System  Continued Successful Growth Track                       Cumulative Test Volume by Quarter      ...
The BioMed Model in HealthcareIT + Dx, Translational Medicine Critical to CT                                        Phyzio...
Business Models in Healthcare IndustryAttractive features of the BioMed business            BioMed                        ...
Drivers for Personalized MedicineAlignment of Quality Healthcare, Insurance                PhyzioType Systems  Diagnosis  ...
Drivers for Personalized MedicineThe Consumer formerly known as Patient• Genomics is expected to  arrive at the clinic• Ne...
Drivers for Personalized MedicineFDA and Regulatory Policy              “The FDA and the drug industry both              f...
Drivers for Personalized MedicineEntrepreneurs                                    16
DNA-Guided Medicine: Beyond AverageMedical GPS: Genetic Prescription System                      20th Century:          21...
Thank You !g.ruano@genomas.net     860-545-3773 www.genomas.comDNA-Guided Medicine   18
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CVG’s Venture Connection-Gualberto Ruano on the opportunity for innovation in the translation of Biomedics into clinical practice

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Great potential for innovation and impact on patient outcomes in personalized medicine lies in theranostics according to personal medicine pioneer Gualberto Ruano. Ruano spoke at CVG’s Venture Connection program at UConn’s Business School in Hartford earlier this month. He sees the prime opportunity for innovation in the translation of Biomedics into clinical practice. Greg Zaic, principal at NMT Capital spoke about the development of pharma into very individualized treatments He foresees our children receiving very specific, highly successful therapies. However, the cost of research and development for all those solutions to disease management when before there were only a few options will be very expensive.

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CVG’s Venture Connection-Gualberto Ruano on the opportunity for innovation in the translation of Biomedics into clinical practice

  1. 1. DNA-Guided Medicine 15 September 2011Why are We Investing in Personalized Medicine? DNA-Guided Healthcare in All-Too-Real-time Gualberto Ruaño, M.D., Ph.D. President, Genomas Inc. Director of Genetics Research, Hartford Hospital 1
  2. 2. Genomas OverviewBringing DNA-Guided Medicine to Healthcare Today Genomas has developed and is marketing a unique biomedical platform that utilizes proprietary biomarkers, treatment algorithms, and a web-based physician portal delivery system to provide clinical decision support for physicians and personalized drug treatment for patients  Products are DNA-guided to improve the therapeutic benefit of widely used prescription drugs while also reducing the risk of significant side effects  Patented technology platform, proprietary algorithms and physician interface portal can be extended to a wide range of drug categories  Powerful technology platform initially offered for mental health and already extended to diabetes medications (lipid and glucose lowering)  Currently focusing primarily on Mental Health: Antidepressants (SSRIs, SNRIs), Neuroleptics (first and second generation antipsychotics), Stimulants  Technology platform applicable to numerous disease states; current pipeline in Cardiovascular and Diabetes: Statins, TZDs, Incretins  Founded in 2004, located at in Hartford Hospital, Hartford CT 2
  3. 3. Hartford Hosp., IOL, CLP, THOCC, UPRGenomas Partners in DNA-Guided Medicine Biotechnology DNA-Guided Pharmaceutical Medicine Discovery Development Diagnostic Treatment Technology Biologicals Personalized Healthcare Databases Drugs Prescription Management 3
  4. 4. Genetic Prescription System: Drug GPSPhyzioType Systems + DNA-Guided Medicine PHYZIOTYPE S Y S T E M S LABORATORY OF PERSONALIZED HEALTH Prescribe Right LPH Bringing DNA-Guided Medicine to Healthcare Today 4
  5. 5. PhyzioType SystemsMedical Device for DNA-Guided Medicine PHYZIOTYPE S Y S T E M S PERSONALIZED HEALTH PHP P O R T A L SB12789 SB12781 SB1501 SB1825 SB1541 SB1727 SB1461 SB3039 CR-1 233 202 126 192 227 145 215 225 238 169 149 110 121 104 200 218 168 241 105 214 148 191 132 216 29 26 21 72 40 55 81 58 74 50 54 80 16 34 70 C2 C3 C1 2 SNP Ensemble Biomathematical Physician Assays Algorithms Interface 5
  6. 6. LPH Laboratory of Personalized HealthClinical Lab, Commercial Launchpad  Pioneering high complexity LABORATORY OF PERSONALIZED HEALTH pharmacogenetics laboratory + clinical practice  Anchor for commercialization of PhyzioType Systems throughout New England and nationally LPH  Licensed by CT Dept of Public  Referral Center for Institute of Health (#CL-0644) + R.I.  CLIA certified and registered Living + Mood Disorders Program (Clinical Laboratory Improvement Amendments)  ID #07D1036625 CMS (Centers for  CT-wide distribution and Medicare and Medicaid)  4 successful biannual inspections reimbursement agreement with (most recent June 2011) Clinical Lab Partners  Reimbursement rate >95%  Used by 195 Clinicians in 2010  1141 Patients referred in 2010  53 patient service centers in CT  Subsidiary of Hartford Healthcare 6  3272 PhyzioType tests in 2010
  7. 7. LPH Laboratory of Personalized HealthClinical Lab, Commercial Launchpad CLP Patient Laboratory of Personalized Physician 1 2 3 Service Personalized Health Clinician + Billing Health Portal Physician requests Phlebotomist acquires Genomas prepares HILOmet PhyzioType sample and enters the Messengers bring reports for uploading System and sends requisition into the blood sample to into the PHP, sends patients for a blood CLP system, including Genomas CLIA lab for hard copy results to draw to CLP patient activation of claims. DNA extraction and requesting physician. service centers. genotyping. PAYORS CLP files 3 claims per HILOmet PhyzioType System with payors based on generic molecular diagnostic codes. CLP remits payment to Genomas at a contractually agreed upon rate per 7 component test. 7
  8. 8. PHP Personalized Health PortalDecision Support for Clinical Practice M.D. M.D. M.D. Patient M.D. Clinical Referral M.D. M.D. M.D. M.D. Practice LABORATORY OF M.D. M.D. PERSONALIZED HEALTH PERSONALIZED HEALTH DNA-Guided Medicine PHP LPH P O R T A L PHYZIOTYPE S Y S T E M S DNA Typing Decision Support 8
  9. 9. DRUG SELECTION TABLE: 80 BrandsANTIDEPRESSANTS: Generic (Brand) & Drug Selection 9
  10. 10. HILOmet PhyzioType System Continued Successful Growth Track Cumulative Test Volume by Quarter 2008 2009 20103500 3500 35003000 3000 30002500 2500 25002000 2000 20001500 1500 15001000 1000 1000500 500 500 0 0 0 Qtr 1 Qtr 2 Qtr 3 Qtr 4 Qtr 1 Qtr 2 Qtr 3 Qtr 4 Qtr 1 Qtr 2 Qtr 3 Qtr 4 Ordering Tests Patients Ordering Tests/ Clinicians Ordered Tested Docs Doc 2008 Actual 44 339 124 7.7 2009 Actual 92 820 293 8.8 10 2010 Actual 195 3272 1141 16.7
  11. 11. The BioMed Model in HealthcareIT + Dx, Translational Medicine Critical to CT PhyzioTypeTM Systems Health Personalized Decision Support for Drug Precision Treatment Mental Illness, Diabetes/Cardiovascular 11
  12. 12. Business Models in Healthcare IndustryAttractive features of the BioMed business BioMed BioTech Doctors and Hospitals Big Pharma Personalized health Blockbuster drug $10M investment $100M investment Utility clinical studies Phase I-III Clinical trials 2 years to revenue 10 years to revenue CLIA or device approval FDA drug approval IP on diagnostics and IT IP on biologicals New industry Acquisition by Pharma 1,000’s service tech jobs 100’s selective science jobs 12
  13. 13. Drivers for Personalized MedicineAlignment of Quality Healthcare, Insurance PhyzioType Systems Diagnosis Treatment Doctors Patients Improved Better Patient Care Outcome Reimbursement Payers Superior Value on Health Insurance 13
  14. 14. Drivers for Personalized MedicineThe Consumer formerly known as Patient• Genomics is expected to arrive at the clinic• New medication diagnostics may be required for patient safety• Personalized healthcare will be expected by patients• Health spending accounts and personal choice on healthcare use 14
  15. 15. Drivers for Personalized MedicineFDA and Regulatory Policy “The FDA and the drug industry both foresee a time when physicians will tailor drug treatments for individual patients based on variations in their DNA sequence.” 15 7 January 2004
  16. 16. Drivers for Personalized MedicineEntrepreneurs 16
  17. 17. DNA-Guided Medicine: Beyond AverageMedical GPS: Genetic Prescription System 20th Century: 21st Century: Public Health Personal Health AVERAGE INDIVIDUALIZEDNumber of People You are Here You are Here SD SD Side Effect Risk Side Effect Risk 17
  18. 18. Thank You !g.ruano@genomas.net 860-545-3773 www.genomas.comDNA-Guided Medicine 18

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