The Clinical and Translational Science Awards (CTSA) Program: What can it do for you?


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Meeting: Physician-Scientist Career Development Meeting, New York Academy of Sciences, November 3-5, 2010

Panel: Successful Strategies for the Physician-Scientist

Presentation: The Clinical and Translational Science Awards (CTSA) Program: What can it do for you?

Speaker: Lisa Guay-Woodford, M.D., Professor and Vice Chair of Genetics, CTSA director, University of Alabama, Birmingham

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The Clinical and Translational Science Awards (CTSA) Program: What can it do for you?

  1. 1. The Clinical and Translational Science Awards (CTSA) Program: What can it do for you? <br />Lisa M. Guay-Woodford, MD<br />Professor and Vice Chair<br />Department of GeneticsDirector, Center for Clinical and Translational Science<br />University of Alabama at Birmingham<br />Physician-Scientist Career Development Meeting<br />New York Academy of Sciences<br />November 04-05, 2010<br />
  2. 2. Translational Research<br />Phase 1 translation (T1) research:move a basic discovery into a candidate health application. <br />Phase 2 translation (T2) research: assess the value of T1 application for health practice leading to the development of evidence-based guidelines. <br />Phase 3 translation (T3) research: move evidence-based guidelines into health practice, through delivery, dissemination, and diffusion research. <br />Phase 4 translation (T4) research: evaluate the "real world" health outcomes of a T1 application in practice. <br /> <br />Pre-clinical<br />T1<br />T2<br />T3<br />T4<br />
  3. 3. Translational Research: Lessons from Goldilocks <br />
  4. 4. chasm<br />Over the past 30 years or so …..<br /><ul><li>Enormous resources have been expended for biomedical research. For example, the NIH budget doubled from $13.6 billion in 1998 to $27.3 billion in 2003.
  5. 5. This investment has fueled huge strides in understanding human disease mechanisms.
  6. 6. BUT the commensurate gains in new treatments, diagnostics and prevention have been limited.</li></ul>Butler (2008) Nature 453:840-842<br />
  7. 7. ? too hot<br />? too cold<br />The 2002 NIH budget totaled $22.1 billion<br /><ul><li>$13 billion for basic research
  8. 8. $9.1 billion for applied and developmental research
  9. 9. $787 million for health services research </li></ul>Woolf (2008) JAMA 299:211-213<br />
  10. 10. Impetus for the CTSA Program<br />The Clinical and Translational Science Award Consortium<br />To ensure new discoveries lead to improved public health, clinical science must evolve to better:<br />Implement biomedical discoveries.<br />Develop, test, and bring new prevention strategies into medical practice more rapidly.<br />Catalyze change - lower barriers between disciplines. <br />Encourage creative and innovative approaches.<br />
  11. 11. Building a National CTSA Consortium<br />Building a National CTSA Consortium<br />WA<br />ME<br />MT<br />ND<br />VT<br />MN<br />OR<br />NH<br />ID<br />WI<br />NY<br />SD<br />MA<br />MI<br />RI<br />WY<br />CT<br />IA<br />PA<br />NJ<br />NE<br />NV<br />OH<br />IN<br />DE<br />IL<br />UT<br />MD<br />CO<br />WV<br />VA<br />KS<br />MO<br />CA<br />KY<br />NC<br />TN<br />AR<br />AZ<br />OK<br />SC<br />NM<br />GA<br />AL<br />MS<br />TX<br />LA<br />AK<br />FL<br />HI<br />PR<br />Participating Institutions<br />New members 2010<br />Members<br />CTSA States<br />
  12. 12. The CTSA Philosophy<br />Team Science<br />Working together as a national consortium, CTSA institutions share a common vision to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research. <br />Connectivity<br />Partnerships<br />Collaboration<br />Breaking Down Institutional Barriers<br />
  13. 13. Cultivating Networks: The National Consortium<br />The NIH and CTSA Institutions have established a committee structure to execute the vision and goals of the CTSA Consortium. <br />The consortium will reach 60 member institutions by 2011.<br />
  14. 14. CTSA Strategic Goals<br />To set a national research agenda, CTSA consortium leaders have identified five overarching strategic goals that guide consortium-wide activities:<br />Goal 1: Build national clinical and translational research capability. <br />Goal 2: Provide training and improve career development of clinical and translational scientists. <br />Goal 3: Enhance consortium-wide collaborations.<br />Goal 4: Improve the health of our communities and the nation.<br />Goal 5: Advance T1 translational research to move basic laboratory discoveries and knowledge into clinical testing.<br />
  15. 15.
  16. 16.<br />
  17. 17. Institutional Structure<br />Each CTSA institution has created a home for clinical and translational science that supports areas of research expertise such as biostatistics, clinical trial design and community engagement. <br />Input from the NIH and other federal agencies, industry, and private and community organizations helps guide the work of every CTSA institution.<br />
  18. 18. Transforming Clinical and Translational Research<br />The CTSA National Consortium is transforming clinical and translational research by:<br /><ul><li>Enhancing young scientist career development through improved training and mentoring.
  19. 19. Equipping diverse research teams to solve complex problems in medical research, e.g., supplying cost-effective, centralized biostatistical and informatics support.
  20. 20. Working collaboratively to improve clinical research management efficiency, and to develop best practices, policies and procedures.
  21. 21. Maximizing results by working with private companies and other partners to advance medical discoveries.
  22. 22. Enhancing public trust by reaching out to underserved populations, including racially and ethnically diverse groups as well as those living in rural and inner-city areas.
  23. 23. Bringing technologies to market to help increase and accelerate global access to research tools.</li></li></ul><li>Working Together to Improve Research<br />Through innovative partnerships and collaborations, CTSAs work collectively to benefit the research community by:<br /><ul><li>Providing specialized infrastructure support to NIH-funded scientists.
  24. 24. Maximizing investments in core and other resources increases efficiency and helps NIH support a wide range of researchers and projects.
  25. 25. Creating new fields of study or new uses for technologies.
  26. 26. Engaging community partners to ensure that research moves successfully into clinical practice.
  27. 27. Creating public and private partnerships to speed innovation.</li></li></ul><li>Maximizing Return on Investments<br />New tools and resources generated by the CTSA consortium:<br /><ul><li>ResearchMatch is a secure, electronic volunteer recruitment registry designed to provide individuals nationwide with opportunities to be considered for participation in research studies, including clinical trials.
  28. 28. CTSA-IP is a web-based intellectual property search engine that aggregates and promotes technologies from CTSA institutions and the NIH to enhance research activity and encourage private partnerships across the consortium.
  29. 29. The CTSA Pharmaceutical Assets Portal provides scientists with information about compounds evaluated for specific diseases that might have therapeutic applicability in other conditions.</li></li></ul><li>Academic Drug Discovery<br />✔<br />CCTS Drug Discovery Pilot 2009<br />Project team<br />SRI<br />✔<br />✔<br />✔<br />CCTS Nascent Project Panel<br />Junior-stage Parkinson disease investigator <br />R01 planned for February 2011<br />
  30. 30. The CTSA Program: What can it do for you? <br /><ul><li>Educational support, structured mentoring, and career development.
  31. 31. Guidance with project development, grant applications, manuscript preparation.
  32. 32. Bioinformatics resources and consultation; access to biostatistical support.
  33. 33. Specialized resources (e.g., nursing and bionutrition) for human studies with support in new technologies, regulatory compliance, and the responsible conduct of research.
  34. 34. Access to community networks for community-based participatory research; creation of public and private partnerships to speed innovation.
  35. 35. Social networking within your institution and across the country that enhances connectivity and lower barriers for collaborative research.</li></li></ul><li>Working together as a national consortium, the CTSA institutions share a common vision to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research.<br />YOU are at the center of this vision.<br /><br />