Alzheimer s disease___memory
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Alzheimer s disease___memory






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    Alzheimer s disease___memory Alzheimer s disease___memory Presentation Transcript

    • Alzheimer’s Disease & Memory By: Erica Gaspard ECE 275, Summer 2012
    • Background Information First described by Alois Alzheimer in 1906 Most common form of Dementia German Psychiatrist and Neuropathologist
    • Facts & Figures A progressive, degenerative, and fatal. Most often diagnosed in people 65 and older  Approximate life expectancy is 7 years post diagnosis  About 3% of diagnosed make it 14 or more years Early symptoms are often mistake for “age-related” concerns No cure for this disease One of the MOST costly diseases in today’s society!
    • Signs and Symptoms Confusion or difficulty remembering recent events Irritability with aggression Mood swings Trouble with words and language Long-term memory loss Eventual loss of body function and control  Resulting in death ALL SYMPTOMS CAUSE THE AFFECTED PERSON TO WITHDRAW FROM FAMILY AND SOCIETY.
    • Progression of Alzheimer’s: Pre-Dementia Experience problems with executive functions of attention. The symptoms are associated with aging/stress since they most often affect Daily Living Activities.  Forget whole experiences  Never can recall forgotten information  Lose ability to follow instructions  Find less benefit in/from memory aides such as notes and lists
    • Progression of Alzheimer’s: Early Stages Experience problems with language (shrinking vocabulary) and more executive functions Problem with perception and movement Memory becomes further affected in the episodic, semantic, and implict Affected person may require assistance/supervision with the more demanding activities.
    • Progression of Alzheimer’s: Moderate Stage Memory problems continue to worsen.  Long-term memory becomes impaired Behavioral & neuropsychiatric changes are prevalent now.  Recognizable by wandering, irritability, outbursts of aggression, and language issues Affected person will fail to recognize family and close relatives
    • Progression of Alzheimer’s: Advanced Stage Language becomes single words or is gone completely. Affected person experiences extreme apathy and exhausted. Becomes completely bedridden due to complete loss of muscle mass and mobility. Affected person is COMPLETELY dependent on others for help.
    • Cause of Alzheimer’s Disease The presence of two specific anatomic abnormalities:  Plaques: deposits of proteins called Beta-Amyloids  Tangles: twisted fibers of Tau proteins Researchers believe a deterioration of cell bodies, dendrites, and axons takes place.  Disrupts/blocks communication among nerve cells • Overall result = Gross atrophy of cells and surrounding regions.
    • Treatment Only known treatment currently is cholinergic drugs:  an enzyme blocker that works by restoring the balance of natural substances (neurotransmitters) in the brain • Tacrine • Donepezil • Rivastigmine • Galantemine
    • EBSCO Article Since Alzheimer’s is characterized by memory loss, was speculated that different patterns of repetition would show this too. Found that an increasing amount of physical information was needed – bottom up processes. End result was that the longer the lag time between picture and answer, the more information was forgotten.
    • Bibliography “Alzheimer’s Disease Fact Sheet.” National Institutes of Health: National Institutes on Aging. 27 June 2012. 8 Aug. 2012. < publication/alzheimers-disease-fact-sheet> “What is Alzheimer’s?.” Alzheimer’s Association. 8 Aug. 2012. <> Viggiano, M. Galli, G., Righi, S. Brancati, C. “Visual Recognition Memory in Alzheimer’s Disease: Repetition-Lag Effect.” Experimental Aging Research. 2008. EBSCO. 1 Aug. 2012.