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Airway Management for the
Unborn Patient
Corey W. Iqbal, MD, FAAP
Objectives
• What is an EXIT procedure
• Indications
• Procedural considerations
– Preoperative
– Intraoperative
– Postoperative
• Not that important
Fetal Airway
E.X.I.T. Procedure
Historical Perspective
History of Fetal Surgery
• Michael R. Harrison – 1981
“Father of Fetal Surgery”
• Bladder Obstruction
• CDH
Pulmonary
Hypoplasia
CDH
• 70% survival
– Pulm hypoplasia
– Pulm HTN
CHAOS
Managing the Airway
OOPS!!!
• Operation On Placental Support
• Ex-utero Intra-partum Therapy (EXIT)
NOT A CESAREAN SECTION
EXIT
• Placental Circulation
– Placenta as bypass pump
• Uterine atony
– Deep general anesthesia
– Tocolytics
• Hemorrhage risk*
Cesarean
• Uterine contraction
• No placental circulation
• Regional anesthesia
• “Slash & Dash”
Indications
• Any anomaly where cardiopulmonary
collapse off placental/fetal circulation
– Airway
• Fetal neck mass
• CHAOS
• Micrognathia
– Thoracic lesions
• Lung lesions
• CDH
– Congenital heart disease
– SCT
EXIT-to-???
• EXIT-to-airway
– Oral endotracheal
– Trachesotomy
• EXIT-to-resection
• EXIT-to-ECMO
Fetal Considerations
– Pain – fetal cocktail
– Monitoring
• US
• Pulse Oximetry
• Temperature
– Venous access
Maternal Considerations
• DVT risk
• Position – right side up
• Epidural
• DEEP general anesthesia
– Uterine atony
• Tocolytics
– Nitroglycerin
– Terbutaline
• Hemorrhage risk
Preoperative
• Patient selection
• Fetal Neck Mass
– Obtain MRI – repeat between 30-34 weeks
– TEDI score >12
– Teratoma
– Polyhydramnios
Cass et al. JPS. 2012;47:46-50
Fetal Neck Mass
• Survival without EXIT
– 0-20%
• Survival with EXIT
– 83%
• ALL EXITs 
– UCSF survival 71%
Iqbal et al. In Submission
Fetal Neck Mass
• 36 year old
Fetal MRI
Aerodigestive Compression
Deviated Trachea Small Stomach
Intraoperative
• Low transverse incision to expose uterus
• Placental mapping by ultrasound
• Hysterotomy
• Tocolytics
– Nitro
– Terbutaline
Intraoperative
Intraoperative
• Fetal cocktail
– Fentanyl + rocuronium
• Pulse oximetry
– HR
– SpO2
• Temp probe
• +/-Fetal IV access
– Pressors: epi, atropine
– Fluid resuscitation
Intraoperative
Other Indications
• CDH – Boston data does not support
– EXIT-to-ECMO: 33% vs 50% survival
• Lung lesions
– 100% survival; discharge at 10 days
– 71% survival without EXIT
Buchmiller et al. JPS. 2012;47:1053-1057
Lee et al. JPS. 2013;48:138-144
Other Indications
• Congenital Heart Disease
– HLHS with in tact septum
– Delivery in OR with immediate cath
• Other neoplasms
– SCT
– Little data to support
Congenital Lung Lesions
Delivery
• Secure airway – paralytics on board
• Clamp chord and deliver
– Obtain chord blood gas
• Anesthesia
– Reduce inhalation
– Administer pitocin
• Now becomes a Cesarean
Crowd Control
Postoperative
• Mom  C-sxn
– Pain control
– ADAT
– 4 days
• Baby
– Work-up
– Definitive treatment
Other Scenarios
• CHAOS
– Fetoscopy
Fetal Bronchoscopy
Questions

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Airway Management for the Unborn Patient by Dr. Corey Iqbal, Chief, Section of Fetal Surgery, Children's Mercy Kansas City, Assistant Professor of Surgery, UMKC