POPULOMICS AND PERSONALIZED
MEDICINE
Bradford W. Hesse, PhD
Chief, NCI Health Comm. and Informatics Research
Friday, March...
Wired Magazine, July 2010
•Invested $50 million in
Parkinson’s research
•Started public blog on
LRRK2
•Is leveraging the p...
Data-Intensive Research Paradigm
to Speed Discovery?
Traditional Model
•Hypothesis
•Studies
•Data aggregation
•Analysis
•W...
Data-Intensive Research Paradigm
to Speed Discovery?
Genetics Initiative
•Tool construction
•Recruitment
•Analysis
•Presen...
A Fourth Paradigm in Science?
Friday, March 14, 14
A New Era in Health?
:,
DPE,.LJ
IERLTH
mAP OF DISIUPTILsE IWWDIIRTIORJ
The Institute for the Future’s Health Horizons Prog...
A Fourth Paradigm in Science?
Molecules to Populations
Genomics
Nanotechnology
ProteomicsPopulomics
Forman MR, Greene SM, ...
Platforms for participation
Harnessing collective
intelligence
Data as the new “Intel
Inside”
End of the software
release ...
Platforms for participation
Harnessing collective
intelligence
Data as the new “Intel
Inside”
End of the software
release ...
Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun.
ACM. 1993;36...
Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun.
ACM. 1993;36...
Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun.
ACM. 1993;36...
Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun.
ACM. 1993;36...
Hesse, B. W., Hansen, D., Finholt, T., Munson, S., Kellogg, W., & Thomas, J. C. (2010). Social Participation in Health
2.0...
Hesse, B. W., Hansen, D., Finholt, T., Munson, S., Kellogg, W., & Thomas, J. C. (2010). Social Participation in Health
2.0...
• Software above single device
Hesse BW. Enhancing Consumer Involvement in Health Care. In: Parker JC, Thornson E, eds. He...
Hesse BW. Time to reboot: resetting health care to support tobacco dependency treatment services. Am J Prev Med.
Dec 2010;...
The Learning Healthcare System
Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine...
The Learning Healthcare System
Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine...
The Learning Healthcare System
Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine...
Hesse BW. Public Health Informatics. In: Gibbons MC, editor. eHealth Solutions for Healthcare
Disparities. NewYork, NY: Sp...
Stay Tuned!
Friday, March 14, 14
Upcoming SlideShare
Loading in …5
×

Populomics, personalized medicine

379 views

Published on

An explanation for why the catalytic effects of networked science is the only way to move precision medicine beyond its current production line logjam.

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
379
On SlideShare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
7
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Populomics, personalized medicine

  1. 1. POPULOMICS AND PERSONALIZED MEDICINE Bradford W. Hesse, PhD Chief, NCI Health Comm. and Informatics Research Friday, March 14, 14
  2. 2. Wired Magazine, July 2010 •Invested $50 million in Parkinson’s research •Started public blog on LRRK2 •Is leveraging the power of “big data” to accelerate the science •Helped found, with wife Anne Wojcicki, 23andMe Friday, March 14, 14
  3. 3. Data-Intensive Research Paradigm to Speed Discovery? Traditional Model •Hypothesis •Studies •Data aggregation •Analysis •Writing •Submission •Acceptance (NEJM) •Publication Time Elapsed: 6 years Friday, March 14, 14
  4. 4. Data-Intensive Research Paradigm to Speed Discovery? Genetics Initiative •Tool construction •Recruitment •Analysis •Presentation Time Elapsed: 8 months Friday, March 14, 14
  5. 5. A Fourth Paradigm in Science? Friday, March 14, 14
  6. 6. A New Era in Health? :, DPE,.LJ IERLTH mAP OF DISIUPTILsE IWWDIIRTIORJ The Institute for the Future’s Health Horizons Program has developed a new paradigm for disruptive innovation in the global health economy—we call it “Open Health.” This paradigm leverages the concepts and successes of open innovation and open-source software, and applies them to the world of health. Open Health strategies will redefine the research and development process and will require a radically new way of thinking about innovation systems, the institutional culture of firms, partnerships, and collaborations, and the very meaning of health itself. The implications of Open Health are relevant to all stakeholders in the global health economy, be they beauty, food, consumer electronics, biopharma, health care, or medical technology companies. As it diffuses across industries, Open Health will inspire new approaches to meeting significant global health problems, and it will provide a framework for generating and sustaining new business models of tomorrow. We have identified ten core principles that serve as a foundation for implementing Open Health strategies. This map presents these principles in the context of emerging trends and innovation leaders. It describes the external forces that are driving Open Health and emphasizes the networks and culture, the ethos and skills, the business models and strategies, and the tools and platforms that will shape innovation systems in the global health economy over the next decade. The Open Health Map of Disruptive Innovation (SR-1117A) is your guide to putting Open Health into practice. Use it, along with its companion piece, the Open Health Toolkit: A Framework for Innovation (SR-1117B), to build the capacity to innovate to solve health’s pressing problems. A Fourth Paradigm in Science? Friday, March 14, 14
  7. 7. A Fourth Paradigm in Science? Molecules to Populations Genomics Nanotechnology ProteomicsPopulomics Forman MR, Greene SM, Avis NE, et al. Bioinformatics: Tools to accelerate population science and disease control research. Am J Prev Med. Jun 2010;38(6):646-651. Friday, March 14, 14
  8. 8. Platforms for participation Harnessing collective intelligence Data as the new “Intel Inside” End of the software release cycle Lightweight programming models Software above the level of the single device Rich user experience From Web 2.0 to Health 2.0 *Source: http://oreilly.com/web2/archive/what-is-web-20.html Facets of Web 2.0* Friday, March 14, 14
  9. 9. Platforms for participation Harnessing collective intelligence Data as the new “Intel Inside” End of the software release cycle Lightweight programming models Software above the level of the single device Rich user experience From Web 2.0 to Health 2.0 *Source: http://oreilly.com/web2/archive/what-is-web-20.html Facets of Web 2.0*Facets of Web 2.0* Platforms for participation Harnessing collective intelligence Data as the new “Intel Inside” End of the software release cycle Lightweight programming models Software above the level of the single device Rich user experience Friday, March 14, 14
  10. 10. Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101. Friday, March 14, 14
  11. 11. Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101. Friday, March 14, 14
  12. 12. Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101. Friday, March 14, 14
  13. 13. Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101. • Data Liquidity Friday, March 14, 14
  14. 14. Hesse, B. W., Hansen, D., Finholt, T., Munson, S., Kellogg, W., & Thomas, J. C. (2010). Social Participation in Health 2.0. IEEE Computer, 43(12), 45-52. • Platforms for Participation • Harnessing Collective Intelligence Friday, March 14, 14
  15. 15. Hesse, B. W., Hansen, D., Finholt, T., Munson, S., Kellogg, W., & Thomas, J. C. (2010). Social Participation in Health 2.0. IEEE Computer, 43(12), 45-52. • Platforms for Participation • Harnessing Collective Intelligence Friday, March 14, 14
  16. 16. • Software above single device Hesse BW. Enhancing Consumer Involvement in Health Care. In: Parker JC, Thornson E, eds. Health Communication in the New Media Landscape. New York, NY: Springer Publishing Company; 2008:119-149. Friday, March 14, 14
  17. 17. Hesse BW. Time to reboot: resetting health care to support tobacco dependency treatment services. Am J Prev Med. Dec 2010;39(6 Suppl 1):S85-87. ClearPractice, Inc. • Rich User Experience Friday, March 14, 14
  18. 18. The Learning Healthcare System Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine. Translational Behavioral Medicine. 2011;1(1):175-181. Friday, March 14, 14
  19. 19. The Learning Healthcare System Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine. Translational Behavioral Medicine. 2011;1(1):175-181. Friday, March 14, 14
  20. 20. The Learning Healthcare System Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine. Translational Behavioral Medicine. 2011;1(1):175-181. Friday, March 14, 14
  21. 21. Hesse BW. Public Health Informatics. In: Gibbons MC, editor. eHealth Solutions for Healthcare Disparities. NewYork, NY: Springer; 2007. p. 109-129. Data-informed Personalized Medicine Friday, March 14, 14
  22. 22. Stay Tuned! Friday, March 14, 14

×