(Understand &) Explain
                 Pain


 Lorimer Moseley
 NHMRC Senior Research Fellow
 Prince of Wales Medical Res...
Nociception is neither sufficient
        nor necessary for pain



                                  © GL Moseley
       ...
The relationship between
nociception and pain is variable



                                  © GL Moseley
              ...
Pain
       Tissue
       danger




       pain



                Take action –
                remove danger
          ...
© GL Moseley
www.BodyInMind.com.au
Complex reasoning
 mechanisms based on
  experience, context,
environment…MEANING




                    © GL Moseley
   ...
Complex reasoning
p ain    mechanisms based on
          experience, context,
        environment…MEANING




            ...
Complex reasoning
 mechanisms based on
  experience, context,
environment…MEANING

     “How dangerous
      is this reall...
Pain does not provide an accurate
indication of tissue state –

It makes us take action to promote
our well-being (get out...
Every represented byte can modulate




                                  Pain



        ‘Basic’ protective responses


 ...
Every represented byte can modulate




                                  Pain



        ‘Basic’ protective responses


 ...
Every represented byte can modulate




                                  Pain



        ‘Basic’ protective responses


 ...
Every represented byte can modulate




                                  Pain



        ‘Basic’ protective responses


 ...
Every represented byte can modulate




                                  Pain



        ‘Basic’ protective responses


 ...
multi-system
   outputs

“How dangerous
 is this really?”




                              © GL Moseley
                 ...
Every represented byte can modulate

Sum evaluative inputs = “It is not as dangerous as that”




                        ...
Every represented byte can modulate

  Sum evaluative inputs = “It is not as dangerous as that”




                      ...
Every represented byte can modulate

  Sum evaluative inputs = “It is not as dangerous as that”




                      ...
Every represented byte can modulate

  Sum evaluative inputs = “It is not as dangerous as that”




                      ...
Every represented byte can modulate

Sum evaluative inputs = “It is more dangerous that that”




                        ...
Every represented byte can modulate

  Sum evaluative inputs = “It is more dangerous that that”




                      ...
Every represented byte can modulate

  Sum evaluative inputs = “It is more dangerous that that”




                      ...
Every represented byte can modulate

  Sum evaluative inputs = “It is more dangerous that that”




                      ...
Thanks



Lorimer Moseley
NHMRC Senior Research Fellow
Prince of Wales Medical Research Institute, Sydney, Australia


Sen...
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How dangerous is this really?

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The relationship between the brain and our experience of pain

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How dangerous is this really?

  1. 1. (Understand &) Explain Pain Lorimer Moseley NHMRC Senior Research Fellow Prince of Wales Medical Research Institute, Sydney, Australia Senior Fellow The GAMFI project University of Oxford, UK © GL Moseley www.BodyInMind.com.au
  2. 2. Nociception is neither sufficient nor necessary for pain © GL Moseley www.BodyInMind.com.au
  3. 3. The relationship between nociception and pain is variable © GL Moseley www.BodyInMind.com.au
  4. 4. Pain Tissue danger pain Take action – remove danger © GL Moseley www.BodyInMind.com.au
  5. 5. © GL Moseley www.BodyInMind.com.au
  6. 6. Complex reasoning mechanisms based on experience, context, environment…MEANING © GL Moseley www.BodyInMind.com.au
  7. 7. Complex reasoning p ain mechanisms based on experience, context, environment…MEANING © GL Moseley www.BodyInMind.com.au
  8. 8. Complex reasoning mechanisms based on experience, context, environment…MEANING “How dangerous is this really?” © GL Moseley www.BodyInMind.com.au
  9. 9. Pain does not provide an accurate indication of tissue state – It makes us take action to promote our well-being (get out of danger!) © GL Moseley www.BodyInMind.com.au
  10. 10. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
  11. 11. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
  12. 12. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
  13. 13. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
  14. 14. Every represented byte can modulate Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
  15. 15. multi-system outputs “How dangerous is this really?” © GL Moseley www.BodyInMind.com.au
  16. 16. Every represented byte can modulate Sum evaluative inputs = “It is not as dangerous as that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
  17. 17. Every represented byte can modulate Sum evaluative inputs = “It is not as dangerous as that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending inhibition www.BodyInMind.com.au
  18. 18. Every represented byte can modulate Sum evaluative inputs = “It is not as dangerous as that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending inhibition www.BodyInMind.com.au
  19. 19. Every represented byte can modulate Sum evaluative inputs = “It is not as dangerous as that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending inhibition www.BodyInMind.com.au
  20. 20. Every represented byte can modulate Sum evaluative inputs = “It is more dangerous that that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley www.BodyInMind.com.au
  21. 21. Every represented byte can modulate Sum evaluative inputs = “It is more dangerous that that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending facilitation www.BodyInMind.com.au
  22. 22. Every represented byte can modulate Sum evaluative inputs = “It is more dangerous that that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending facilitation www.BodyInMind.com.au
  23. 23. Every represented byte can modulate Sum evaluative inputs = “It is more dangerous that that” Pain ‘Basic’ protective responses Motor system Immune system Autonomic system © GL Moseley Descending facilitation www.BodyInMind.com.au
  24. 24. Thanks Lorimer Moseley NHMRC Senior Research Fellow Prince of Wales Medical Research Institute, Sydney, Australia Senior Fellow The GAMFI project University of Oxford, UK © GL Moseley www.BodyInMind.com.au

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