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16:   Ribosome at work ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
16:  Ribosome with mRNA and tRNA ,[object Object]
Ribosome is a ribozyme ,[object Object],[object Object],[object Object],[object Object],[object Object]
Initiation of translation ,[object Object],[object Object],[object Object],[object Object]
Initiation of translation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
17:  Initiation of prokaryotic translation ,[object Object],[object Object],[object Object],[object Object]
18:  Elongation cycle
18:  Elongation cycle
18:  Elongation cycle
18:  Elongation cycle Every coupling  costs 2 x GTP
19:  Termination of translation ,[object Object],[object Object]
19:  Termination of translation ,[object Object],[object Object]
19:  Termination of translation ,[object Object],[object Object]
Translation movie 2 movies Film 2 = ‘movie 11 translatie’ in WebCT
How starts and ends a ribosome? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Eukaryotic differences ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Initiation of eukaryotic protein synthesis From Alberts, Essential cell biology ,[object Object],[object Object],[object Object],[object Object],[object Object]
Initiation of eukaryotic protein synthesis From Alberts, Essential cell biology ,[object Object],[object Object],[object Object],[object Object],[object Object]
Initiation of eukaryotic protein synthesis From Alberts, Essential cell biology ,[object Object],[object Object],[object Object],[object Object],[object Object]
Initiation of eukaryotic protein synthesis From Alberts, Essential cell biology ,[object Object],[object Object],[object Object],[object Object],[object Object]
22:  Difference eu- and prokaryotes ,[object Object],[object Object],[object Object],[object Object]
24:  Poly(ribo)somes ,[object Object],[object Object]
22:  Difference eu- and prokaryotes ,[object Object],[object Object],[object Object],[object Object]
After synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
21:  Targeting proteins to organelles ,[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
22:  Mutations can cause disease ,[object Object],[object Object]
22:  Mutations can cause disease ,[object Object],[object Object]
Types of mutations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of mutations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
23:  Types of mutations
23:  Types of mutations
25:  Summary of Tc and Tl
Summary-test yourself! DNA synthesis RNA synthesis Protein synthesis Start Stop
Summary-test yourself! DNA synthesis RNA synthesis Protein synthesis Start Stop Ori
Summary-test yourself! Replication fork/telomere DNA synthesis RNA synthesis Protein synthesis Start Stop Ori
Summary-test yourself! Replication fork/telomere DNA synthesis RNA synthesis Protein synthesis Promoter  (TATAA) Start Stop Ori
Summary-test yourself! Replication fork/telomere DNA synthesis RNA synthesis Protein synthesis Promoter  (TATAA) RNA sequence or terminator Start Stop Ori
Summary-test yourself! Replication fork/telomere DNA synthesis RNA synthesis Protein synthesis Promoter  (TATAA) RNA sequence or terminator AUG Start Stop Ori
Summary-test yourself! Replication fork/telomere DNA synthesis RNA synthesis Protein synthesis Promoter  (TATAA) RNA sequence or terminator STOP or UAA, UAG, UGA AUG Start Stop Ori
From bp to aa ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],mRNAs are longer than the amino acid encoding part

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