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Gene structure; which mRNAs? HIV 2008   LTR: promoter long terminal repeat Splice variants    Vpu from same mRNA as Env
6.  First role of Vpu: degradation of CD4 from: Bour and Strebel,   Microbes and Infection 5 (2003) 1029–1039 ,[object Object],[object Object],[object Object],[object Object],HIV 2008
6. Second role of Vpu: release of maturing virus HIV 2008   HIV  Vpu HIV.WT Neil et al., 2008  Nature 451, 425-430
6. Second role of Vpu: release of maturing virus HIV 2008   Varthakavi et al.,  Nature med. 14, 2008, 641-647 Göttlinger Nature AOL, 160108 HIV  Vpu HIV.WT Neil et al., 2008  Nature 451, 425-430
6. Second role of Vpu: release of maturing virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008   Varthakavi et al.,  Nature med. 14, 2008, 641-647 Göttlinger Nature AOL, 160108 HIV  Vpu HIV.WT Neil et al., 2008  Nature 451, 425-430
6. Second role of Vpu: release of maturing virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008   ,[object Object],[object Object],[object Object],Varthakavi et al.,  Nature med. 14, 2008, 641-647 Göttlinger Nature AOL, 160108 HIV  Vpu HIV.WT Neil et al., 2008  Nature 451, 425-430
Animation of viral life cycle I ,[object Object],[object Object],[object Object],HIV 2008
Niet leren! Achterhaald HIV 2008   YouTube filmpje over replicatie? Kijk naar: http://www.flabber.nl/archief/022970.php
AIDS in 1988 Gallo and Montagnier, Sci Am 259-4, 1988, 25-32 ,[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008
HIV budding from microvillus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008
Virus in EM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008
Virus in EM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008   Original first photo of HIV (LAV), made in Pasteur-institute, Paris, on Friday February 4, 1983 by Charlie Dauguet  Nature Med 9, 2003, 845
Koch’s postulates  Gallo and Montagnier   ,[object Object],[object Object],[object Object],[object Object],HIV 2008
Koch’s postulates  Gallo and Montagnier   ,[object Object],[object Object],[object Object],[object Object],HIV 2008
Koch’s postulates  Gallo and Montagnier   ,[object Object],[object Object],[object Object],[object Object],HIV 2008
Koch’s postulates  Gallo and Montagnier   ,[object Object],[object Object],[object Object],[object Object],HIV 2008
Koch’s postulates  Gallo and Montagnier   ,[object Object],[object Object],[object Object],[object Object],HIV 2008
Literatuur ,[object Object],[object Object],[object Object]
HIV causes AIDS ! ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],HIV 2008
Main targets of HIV  ,[object Object],[object Object],[object Object],[object Object],HIV 2008   ,[object Object],[object Object],[object Object],[object Object], ,[object Object],[object Object],[object Object],[object Object]
Ongoing HIV gene therapy trials: Jon Cohen, Science 317, 2007, 612-614 HIV 2008   Investigators  Sponsors  Vector  Transduced Genes Encode  Protocol  Development Stage  Jerome Zack and Ronald Mitsuyasu, UCLA  Johnson& Johnson Research, Sydney, Aus  Moloney murine leukemia virus  Ribozyme that targets HIV  tat   CD34 +  cells, no conditioning  74 patients in randomized, controlled phase II trial. Results expected early 2008 Carl June, Univ of Pennsylvania  VIRxSYS, Gaithersburg, Maryland, NIH Modified HIV  Antisense that targets HIV  env   CD4 +  cells, no conditioning  Two studies with 65 patients. First results expected in fall  Carl June  Sangamo BioSciences, Richmond, Ca  Adenovirus  Zinc finger nucleases that target CCR5  CD4 +  cells, no conditioning  12 patients, expected to start later this year  Donald Kohn, Children's Hospital,  LA, USA  NIH  Modified HIV  RevM10 that overrides HIV  rev   CD34 +  cells, ablation with busulfan  12 patients failing therapy expected to start in early 2008  John Rossi and John Zaia, City of Hope, Duarte, Ca, USA  NIH  Modified HIV  Short RNA anti HIV  rev  and  tat , ribozyme anti CCR5, TAR decoy anti  tat   CD34 +  cells, myeloablation  5 patients with AIDS lymphoma, enrolling  Dorothee von Laer, Georg- Speyer-Haus,   Frankfurt, Fresenius Biotech, Vision7 GmbH, EU  MMLV  Peptide that disrupts HIV's gp41  CD34 + cells, ablation by chemotherapy 5 patients with AIDS lymphoma, start later this year Baltimore, Björkman, Caltech, Pasadena,   Bill and Melinda Gates Foundation  Modified HIV  Lab-designed anti-HIV antibody  CD34 +  cells  Mouse studies  Irvin Chen, UCLA  NIH  Modified HIV  si RNA against CCR5  CD34 +  cells  Monkey studies
Circumcision in the news: Nature 15 december 2006 ,[object Object],[object Object],[object Object],[object Object],HIV 2008   Group HIV cases Circumcised 20 Control 49

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GKA deel 2 college 4

  • 1. Gene structure; which mRNAs? HIV 2008 LTR: promoter long terminal repeat Splice variants  Vpu from same mRNA as Env
  • 2.
  • 3. 6. Second role of Vpu: release of maturing virus HIV 2008 HIV  Vpu HIV.WT Neil et al., 2008 Nature 451, 425-430
  • 4. 6. Second role of Vpu: release of maturing virus HIV 2008 Varthakavi et al., Nature med. 14, 2008, 641-647 Göttlinger Nature AOL, 160108 HIV  Vpu HIV.WT Neil et al., 2008 Nature 451, 425-430
  • 5.
  • 6.
  • 7.
  • 8. Niet leren! Achterhaald HIV 2008 YouTube filmpje over replicatie? Kijk naar: http://www.flabber.nl/archief/022970.php
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21. Ongoing HIV gene therapy trials: Jon Cohen, Science 317, 2007, 612-614 HIV 2008 Investigators Sponsors Vector Transduced Genes Encode Protocol Development Stage Jerome Zack and Ronald Mitsuyasu, UCLA Johnson& Johnson Research, Sydney, Aus Moloney murine leukemia virus Ribozyme that targets HIV tat CD34 + cells, no conditioning 74 patients in randomized, controlled phase II trial. Results expected early 2008 Carl June, Univ of Pennsylvania VIRxSYS, Gaithersburg, Maryland, NIH Modified HIV Antisense that targets HIV env CD4 + cells, no conditioning Two studies with 65 patients. First results expected in fall Carl June Sangamo BioSciences, Richmond, Ca Adenovirus Zinc finger nucleases that target CCR5 CD4 + cells, no conditioning 12 patients, expected to start later this year Donald Kohn, Children's Hospital, LA, USA NIH Modified HIV RevM10 that overrides HIV rev CD34 + cells, ablation with busulfan 12 patients failing therapy expected to start in early 2008 John Rossi and John Zaia, City of Hope, Duarte, Ca, USA NIH Modified HIV Short RNA anti HIV rev and tat , ribozyme anti CCR5, TAR decoy anti tat CD34 + cells, myeloablation 5 patients with AIDS lymphoma, enrolling Dorothee von Laer, Georg- Speyer-Haus, Frankfurt, Fresenius Biotech, Vision7 GmbH, EU MMLV Peptide that disrupts HIV's gp41 CD34 + cells, ablation by chemotherapy 5 patients with AIDS lymphoma, start later this year Baltimore, Björkman, Caltech, Pasadena, Bill and Melinda Gates Foundation Modified HIV Lab-designed anti-HIV antibody CD34 + cells Mouse studies Irvin Chen, UCLA NIH Modified HIV si RNA against CCR5 CD34 + cells Monkey studies
  • 22.