11 © 2009 PerkinElmer© 2009 PerkinElmer© 2009 PerkinElmer© 2009 PerkinElmer
Buckeye Growth Partners
Solect
Kevin Hrusovsky...
22
Buckeye
Growth
Partners
Buckeye
Growth
PartnersAgenda
Personalizing Global Health
1
2
3
State of Health
Personalized He...
33
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Life Expectancy Gains are Slowing
Lifestyle is Undermining Medical Prog...
44
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Jaring Timmerman, 100
World record for backstroke
Jiroemon Kimura, 115
...
55
Buckeye
Growth
Partners
Buckeye
Growth
Partners
US Healthcare: Poorer Outcomes - Greater Cost
Forbes (March 2013)
$3 tr...
66
Buckeye
Growth
Partners
How Safe is US Healthcare?
CDC (2003); NHS National Patient Safety Agency & the Health Foundati...
77
Buckeye
Growth
Partners
Buckeye
Growth
Partners“One Size Fits All” Does not work; $1 Trillion Wasted
Adverse drug react...
88
Buckeye
Growth
Partners
Buckeye
Growth
PartnersDrugs’ Toxic Side Effects
Warnings
Users may be at a higher risk of
 Ul...
99
Buckeye
Growth
PartnersJapan is Living Longer than US
Life Expectancy
U.S. Health in International Perspective: Shorter...
1010
Buckeye
Growth
Partners
Buckeye
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PartnersCancer: #1 Killer in the World and Japan
http://www.jcancer.jp/english...
1111
Buckeye
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PartnersJapan is Using Less Energy and Living Longer than US
Life Expectancy at Birth
(Men, Women)
U.S...
1212
Buckeye
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Partners
Buckeye
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PartnersJapan has one of the lowest levels of obesity
http://steadfastfinances...
1313
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Buckeye
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PartnersJapan Public Health Centre
Source: American Journal of Clinical Nutrit...
1414
Buckeye
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Partners
Buckeye
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Partners2/3 of People are Overweight
 Obesity is a global epidemic
 Costs qu...
1515
Buckeye
Growth
Partners
Buckeye
Growth
PartnersAchieving food addiction is a SCIENCE
70% consumed by Americans is pro...
1616
Buckeye
Growth
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Buckeye
Growth
Partners
Globally, We Use More Energy and Eat Bigger Meals
1717
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Earth
4.5B years old
Life
2B years old
Industrial Revolution; 11:59:5...
1818
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Earth
4.5B years old
Life
2B years old
Industrial Revolution; 11:59:5...
1919
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Earth
4.5B years old
Life
2B years old
Industrial Revolution; 11:59:5...
2020
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Earth
4.5B years old
Life
2B years old
Industrial Revolution; 11:59:5...
2121
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Earth
4.5B years old
Life
2B years old
Industrial Revolution; 11:59:5...
2222
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Subsidies Sugarcane
Corn
$
Prices
Lowered
Subsidies lead to Unintende...
2323
Buckeye
Growth
Partners
Buckeye
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Sugarcane
Corn
Cows
Salmon
Chicken
Pesticides
Growth Hormones
Antibio...
2424
Buckeye
Growth
Partners
Buckeye
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Cows
Salmon
Chicken
Cancer
Heart
Disease
Diabetes Stroke
Over-Stimula...
2525
Buckeye
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Buckeye
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69 year old truck driver
Photoaging - Sun exposure
2626
Buckeye
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Buckeye
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PartnersBreast Cancer - Rising Incidence on a Global Scale
Obesity & exercise
...
2727
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Buckeye
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Personalized Medicine
2828
Buckeye
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Buckeye
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Personalized Medicine Health
INFORMATICS
2929
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Buckeye
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PartnersAgenda
Revolutionizing & Personalizing Global Health
1
2
3
State of He...
3030
Buckeye
Growth
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Buckeye
Growth
PartnersPersonalized Health – Asymptomatic Medicine…
Source: http://www.slides...
3131
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Buckeye
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GLOBAL HEALTH REVOLUTION
Extend Productive Life Economically
77 100
3232
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Take Away Goes Here
Translating Genomics into Precision Medicine
Structure of
genomes
Biology...
3333
Buckeye
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Partners
Buckeye
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Commercial Prospects for Genomic Sequencing Technologies
Nature Revie...
3434
Buckeye
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DRUG TARGET COMPANY INDICATION STATU...
3535
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Buckeye
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Propelling personalized medicine through MDx
Profound Growth of Molec...
3636
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Biomarker Tests to Improving Efficacy / Safety
$2B
$4B
$5B
REQUIRES biomarker test for
26 app...
3737
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“A major breakthrough in metastatic melanoma
treatment.”
NEJM Editorial, August 26, 2010
“We ...
3838
Buckeye
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Buckeye
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Dumb Cancers
• Single dominant mutation
• Small mutation load
• Monot...
3939
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Buckeye
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Gaddy Getz, Broad Institute 2011
Lung cancer has high rate of somatic...
4040
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Epigenetics
Only 20% of disease
linked to germ line
mutations
Science (2010)
Diet
Drugs
Infec...
4141
Buckeye
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Buckeye
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Javier and Carlos
6 years old
Ann...
4242
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 WHO estimates 6m deaths
from smoking and 0.6M
deaths from SHS
 ¼ o...
4343
Buckeye
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PartnersEpigenetic changes in tumor progression
Increased Histone-modification imbalance
Increased fre...
4444
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Human Microbiome - “The Second Human Genome”
Our bodies contain >100x...
4545
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Microbiome Research is Rising Exponentially
Explosive Growth in Micro...
4646
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Fact or Fallacy
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‘Needing’ forms the
basis of addiction
– you can’t turn it off anymore
4848
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Buckeye
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PartnersFACT -- Defining food addiction
Robert Lustig
Food Provocateur
4949
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Buckeye
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Partners7 Criteria of Addiction:
1
2
3
4
5
6
7
Tolerance – need more substance...
5050
Buckeye
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Buckeye
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PartnersThe Key Players that Determine our Metabolic Fate
DOPAMINE (neurotrans...
5151
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Buckeye
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All Calories
Are NOT Equal
Food as a
Hormone
5252
Buckeye
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PartnersAll Calories are NOT Created Equal
Proteins require 10-20 times as much
energy to digest as fa...
5353
Buckeye
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Buckeye
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PartnersA Big Mac, Large French Fries & Large Coke
The “typical” fast food mea...
5454
Buckeye
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PartnersAll Calories are NOT Created Equal
More energy is needed to digest raw foods
Source: Science. ...
5555
Buckeye
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PartnersCooking increases Body Mass Index
Source: PNAS (Npvember 2011)
Changes in BMI on sweet potato ...
5656
Buckeye
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PartnersAll Calories are NOT Created Equal
Fruit fiber mitigates most of the negative effects of sugar...
5757
Buckeye
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Buckeye
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PartnersOur Craving for Sugar has Consequences
The craving for sugar has contr...
5858
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The Mediterranean Diet
the Evidence is In!
5959
The Mediterranean Diet – the Evidence is In!
For the first time ever, the protective
effect of the Mediterranean Diet...
6060 Confidential
The Mediterranean Diet – the Evidence is In!
7,447 people with CVD risk (but no prior CVD)
were split in...
6161
Buckeye
Growth
PartnersThe Mediterranean Diet – the Evidence is In!
Control Group
Low Fat Diet
Group 1
MD + Olive Oil...
6262
Buckeye
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Buckeye
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PartnersHormones Determine Our Metabolic Fate
When things are working “properl...
6363
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Buckeye
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PartnersWhen Key Players Go Bad…
Hormone resistance – and metabolic disease
Da...
6464
Buckeye
Growth
Partners
Buckeye
Growth
PartnersAgenda
Revolutionizing & Personalizing Global Health
1
2
3
State of He...
6565
Buckeye
Growth
Partners
Buckeye
Growth
Partners
Framework to Inspire Disruptive Innovation – Di5
Capital
Transitions
...
6666
Buckeye
Growth
Partners
Revolutionize Global Health
Innovation Asymptomatic Personalized Sustainability
United Purpos...
6767
Buckeye
Growth
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Chris Maki is ALL IN!
For my three little girls …
6868
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Buckeye
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Chris, Allie and Tommy will never be forgotten
Contributed photo
6969
Buckeye
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Buckeye
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PartnersBridging The Technology Adoption Gap
Win – Win
Technology PatientD
I
S...
7070
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TECHNOLOGY THEMES
Imaging &
Pathology
Biomarkers
Mdx, Cdx
Cellular
Systems
Molecular
Analysis...
7171
Buckeye
Growth
Partners
Buckeye
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Need relevant
predictive models
Biomarkers are
enabling translation
C...
7272
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Buckeye
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In Vitro In Vivo
Small AnimalCellDNA, RNA
Protein
HumanTissue
Top Cha...
7373
Buckeye
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Pre-ClinicalClinical
Goal
COST OF TESTING
DATAQUALITYDisruptive Innov...
7474
Buckeye
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Buckeye
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CONFIDENTIAL
7575 Confidential
Unification of 25 Companies
Life Sciences &
Technology
7676
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Advances in Sequencing Technology Enable Clinical NGS
Cost Prohibitive
Cost Effective
“Cancer...
7777
Buckeye
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Key Bottlenecks in Next Generation Sequencing
Source: The Global Outlook for Next Generation ...
7878
Buckeye
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PartnersMolecular Tools Creating Sea Change of New Applications
Food ID
Agrogenomics
Human Genomics
In...
7979
Buckeye
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Geospiza LIMS and OmicsOffice Visualization
NGS Sample Prep Workflow Solutions
LabChip XT • A...
8080
Buckeye
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PartnersCustomers, Partners & Advocates
AGBT 2012
AGBT 2011
*not a comprehensive list,
over 500 NGS cu...
8181
Buckeye
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PartnersMolecular Tools Creating Sea Change of New Applications
Food ID
Agrogenomics
Human Genomics
In...
8282
Buckeye
Growth
PartnersCancer Treatment Trends at 2013 AACR
Early Detection &
Predisposition
Heterogeneity & Resistan...
8383
Buckeye
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More Testing with Smaller Samples
NGS Multiplex Assays CTC Imaging
Tumor Section Core Biopsy ...
8484
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Buckeye
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Next Gen Pathology
Imperative to Embrace the Sequencing / Imaging Rev...
8585
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Buckeye
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AQUA avoids ~20% ER false negat...
8686
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Buckeye
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Partnerski67 examples (4 patients w/ diff. morphologies)
Pathology today
Nearl...
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Buckeye
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PartnersWe add a tumor marker (red) to guide image analysis.
Can’t be done vis...
8888
Buckeye
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Buckeye
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PartnersinForm generates a tumor mask using pattern recognition
8989
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Buckeye
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PartnersIndividual tumor nuclei are scored pos/neg (blue neg, brown pos)
9090
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Buckeye
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ki67 positivity: 0%
ki...
9191
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Buckeye
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C
BA
D
C
A
B
High AQUALow AQUA
Ki67 Heterogeneity Quantitation
9292
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Buckeye
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DAPI PhalloidinKi67
KeratinSignaling 1 Signaling 2
Circulating Tumor ...
9393
Buckeye
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Buckeye
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PartnersFluorescence-guided surgery example
Color Fluorescence Overlay
• Nu/nu...
9494
Buckeye
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PartnersMolecular Tools Creating Sea Change of New Applications
Food ID
Agrogenomics
Human Genomics
In...
9595
Buckeye
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Buckeye
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Tests
55 available tests
Newborn screening global market opportunity
...
9696
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Buckeye
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Why Autism?
9797
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Buckeye
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Clinically important, scienti...
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What is Autism?
98
9999
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Buckeye
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99
Impaired
Communication
I...
100100
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Buckeye
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100
5 – 20% Genetics
• DNA
•...
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Buckeye
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Buckeye
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101
19 months or earlier
Parents’...
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Buckeye
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Buckeye
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“20% of children have the autism l...
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80% of children with autism are missed before age three
Visit Pedia...
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SynapDx test could identify 90% of children by age three
Get SynapD...
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SynapDx: Accelerate Time to Diagnosis
105
Autism CenterPediatrician...
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Neonatal Diagnosis in Two Days: STAT-Seq
“A lot of people are going to realize that this
is the future.”
Richard Gi...
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Buckeye
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We are building ridiculously small, and
elegantly simple purpose-bu...
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Centralized Model of Scientific Research
Strategic Research
Routi...
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The „Personal Mass Spec‟ Disrupts Scientific Workflows
“Core Faci...
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Human Health Environmental
Health
Side Effects
Dosage
Medicine
Symptoms
Biomarkers
Food Pat...
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N-of-One’s Solutions: Timely  Succinct  Transparent  Clinically ...
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Buckeye
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Pfizer, Sutent ...
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Buckeye
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Personalizing Global Health
1
2
3
State of Health
Personalize...
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Buckeye
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Dr. David Rimm - Yale
Dr. Laur...
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2013 Bioscience Vision Summit - Kevin Hrusovsky: Inspiring a Global Health Revolution

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Kevin Hrusovsky, Former CEO and President of Caliper Life Science and President of PerkinElmer's Life Sciences and Technology group will tackle the current global state of healthcare and will deliver a framework for inciting a global health revolution. He will also discuss how disruptive technologies are enabling personalized health - Cradle to Grave.

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  • Need to personalize specific theraptutics – lots of money wasted in the older pharma model – recent report described that adverse drug reactions are now the 4th leading cause of death – and in terms of efficacy – some of the best thereputics until recently were only 60% efficacious – some particularly cancer therapeutics much worse
  • With transition
  • Figure 1
  • Start off with an example of a collaboration we have with CMH where LST technologies are impacting some of the non-direct production costs …and this team NGS programs are in fact at the cusp of being a really clinically translational tool.Started working with Stephane Kingsmore 4 or 5 years ago when he was at NCGR – with Darrell Dinwiddie…implementing automation and uF to streamline Sample prep. Couple year ago – move to CMH ..implement some of the approaches they had developed in a clinical setting.Developed an NGS based test for 595 recessive monogenic diseases suing NGS …started to implement if clinically
  • N-of-One SAMPLE CASE STUDIES.
  • 2013 Bioscience Vision Summit - Kevin Hrusovsky: Inspiring a Global Health Revolution

    1. 1. 11 © 2009 PerkinElmer© 2009 PerkinElmer© 2009 PerkinElmer© 2009 PerkinElmer Buckeye Growth Partners Solect Kevin Hrusovsky Managing Director BGP Ex - Caliper CEO / PerkinElmer President LST BioForward Vision Summit Cradle To Grave, Health is Personal
    2. 2. 22 Buckeye Growth Partners Buckeye Growth PartnersAgenda Personalizing Global Health 1 2 3 State of Health Personalized Health – Molecular Revolution Inspiring Disruptive Innovation – Di5
    3. 3. 33 Buckeye Growth Partners Buckeye Growth Partners Life Expectancy Gains are Slowing Lifestyle is Undermining Medical Progress First time in 200 years, children’s life expectancy is shorter than parents By 2030 1900 2000Birth Year LifeExpectancy 0 10 20 30 40 50 60 70 80 90 Gains are Plateauing Cancer kills ~8 m/yr: ~72% Diabetes 350M: double Autism 1/88: 57x Asthma / allergies: double
    4. 4. 44 Buckeye Growth Partners Buckeye Growth Partners Jaring Timmerman, 100 World record for backstroke Jiroemon Kimura, 115 World’s Oldest Man Buster Martin, 101 Marathoner, Life Enthusiast Ruth Frith, 100 Shot-put gold medalist Fauja Singh, 100 World’s Oldest Marathon Runner "If you live to the age of a hundred you have it made, because very few people die past the age of a hundred.” - George Burns (1896-1996) Living Longer and Doing More Country 100 yrs + Per 100k China 17,800 1.3 Canada 3,795 11.5 UK 9,330 15 France 14,994 25 Japan 36,376 28 USA 95,548 31
    5. 5. 55 Buckeye Growth Partners Buckeye Growth Partners US Healthcare: Poorer Outcomes - Greater Cost Forbes (March 2013) $3 trillion wasted / year
    6. 6. 66 Buckeye Growth Partners How Safe is US Healthcare? CDC (2003); NHS National Patient Safety Agency & the Health Foundation (2008) 100,000 10,000 1,000 100 10 1 1 10 100 1,000 10,000 100K 1M 10M Number of encounters for each fatality Totalliveslostperyear How safe is Healthcare? Driving in US Chartered Flights Healthcare (1 in ~600) Dangerous (>1/1,000) Ultra Safe (<1/100K) Scheduled Commercial Airlines European Railroads Nuclear Power Chemical Manufacturing Bungee Jumping Mountain Climbing More Dangerous than Bungee Jumping!
    7. 7. 77 Buckeye Growth Partners Buckeye Growth Partners“One Size Fits All” Does not work; $1 Trillion Wasted Adverse drug reactions 4th leading cause of death Toxicity Cancer (all types) 25% Alzheimer disease 30% Hepatitis C 47% Osteoporosis 48% Diabetes 57% Asthma 60% Cardiac arrhythmias 60% Schizophrenia 60% Depression 62% 0% 10% 20% 30% 40% 50% 60% 70% Efficacy Cost: $200B / yr Depression Schizophrenia Cardiac arrhythmia Asthma Diabetes Osteoporosis Hepatitis C AD Cancer 38 cancer drugs approved 2000 - 2010 Increased toxicity for targeted agents • GREATER MORTALITY • GREATER MORBIDITY • MORE SEVERE ADVERSE EVENTS
    8. 8. 88 Buckeye Growth Partners Buckeye Growth PartnersDrugs’ Toxic Side Effects Warnings Users may be at a higher risk of  Ulcers  Amnesia  Heart Attack  Stroke  Enlarged breasts in men  Insomnia  Suicide  Loss of smell & taste  Internal Bleeding  Birth Defects  Loss of Libido  Weight Gain  Seizures
    9. 9. 99 Buckeye Growth PartnersJapan is Living Longer than US Life Expectancy U.S. Health in International Perspective: Shorter Lives, Poorer Health (2013) Correlation Death from Noncommunicable Diseases Life Expectancy at Birth (Men, Women)
    10. 10. 1010 Buckeye Growth Partners Buckeye Growth PartnersCancer: #1 Killer in the World and Japan http://www.jcancer.jp/english/cancerinjapan/ Japan
    11. 11. 1111 Buckeye Growth PartnersJapan is Using Less Energy and Living Longer than US Life Expectancy at Birth (Men, Women) U.S. Health in International Perspective: Shorter Lives, Poorer Health (2013) World Bank (2011) Energy Consumption per Capita (kg of oil equivalent per capita) Inverse Correlation Life Expectancy Energy Consummption
    12. 12. 1212 Buckeye Growth Partners Buckeye Growth PartnersJapan has one of the lowest levels of obesity http://steadfastfinances.com/blog/2010/09/23/global-obesity-rates-making-money-on-the-obesity-epidemic/ Japan has 8x lower rates of obesity than the USA and consumes 10x less sugar 0 5 10 15 20 25 30 India China Japan South Korea Italy Sweden France Netherlands Poland Brazil Turkey Finland Germany Russia Spain Greece Iceland South Africa Chile Canada Britain Australia New Zealand United States Mexico
    13. 13. 1313 Buckeye Growth Partners Buckeye Growth PartnersJapan Public Health Centre Source: American Journal of Clinical Nutrition (October 2012) 21% higher risk of stroke if one soft drink per day Risk of ischemic stroke 83%. Strong evidence linking sweetened soft drinks to obesity, cardiovascular disease, diabetes and cancer. 20% of USA caloric intake
    14. 14. 1414 Buckeye Growth Partners Buckeye Growth Partners2/3 of People are Overweight  Obesity is a global epidemic  Costs quadrupling; $400B (NEJM, 2005; AHRQ, 2006; CBO, 2008; CDC, 2009)
    15. 15. 1515 Buckeye Growth Partners Buckeye Growth PartnersAchieving food addiction is a SCIENCE 70% consumed by Americans is processed food BLISS POINT = optimal sugar, fat & salt Use science (eg. brain scans) to achieve BLISS POINT Irony: Healthy food is not profitable
    16. 16. 1616 Buckeye Growth Partners Buckeye Growth Partners Globally, We Use More Energy and Eat Bigger Meals
    17. 17. 1717 Buckeye Growth Partners Buckeye Growth Partners Earth 4.5B years old Life 2B years old Industrial Revolution; 11:59:59 on Dec 31 Humans 150,000 years old 1800 1B Growth Assaulting Ecosystems - Earth is Fighting Back!
    18. 18. 1818 Buckeye Growth Partners Buckeye Growth Partners Earth 4.5B years old Life 2B years old Industrial Revolution; 11:59:59 on Dec 31 Humans 150,000 years old 1800 1930 1B 2B Growth Assaulting Ecosystems - Earth is Fighting Back!
    19. 19. 1919 Buckeye Growth Partners Buckeye Growth Partners Earth 4.5B years old Life 2B years old Industrial Revolution; 11:59:59 on Dec 31 Humans 150,000 years old 1800 1930 1960 1B 2B 3B Growth Assaulting Ecosystems - Earth is Fighting Back!
    20. 20. 2020 Buckeye Growth Partners Buckeye Growth Partners Earth 4.5B years old Life 2B years old Industrial Revolution; 11:59:59 on Dec 31 Humans 150,000 years old 1800 1930 1960 2011 1B 2B 3B 7B Growth Assaulting Ecosystems - Earth is Fighting Back!
    21. 21. 2121 Buckeye Growth Partners Buckeye Growth Partners Earth 4.5B years old Life 2B years old Industrial Revolution; 11:59:59 on Dec 31 Humans 150,000 years old 1800 1930 1960 2011 1B 2B 3B 7B Growth Assaulting Ecosystems - World is Fighting Back! 4.5B years of stored fossil fuel Greenhouse gas = 400 vs. 250ppm 25k species go extinct/year 80 countries no forest – 52k g w/tree 25 trucks of waste for 1 good Super storms
    22. 22. 2222 Buckeye Growth Partners Buckeye Growth Partners Subsidies Sugarcane Corn $ Prices Lowered Subsidies lead to Unintended Consequences Buckeye Growth Partners
    23. 23. 2323 Buckeye Growth Partners Buckeye Growth Partners Sugarcane Corn Cows Salmon Chicken Pesticides Growth Hormones Antibiotics Increased Productivity – Unintended Consequences on Health Buckeye Growth Partners
    24. 24. 2424 Buckeye Growth Partners Buckeye Growth Partners Cows Salmon Chicken Cancer Heart Disease Diabetes Stroke Over-Stimulated Insulin Growth Hormone Omega 6 Overload Hormone Imbalance Increased Productivity – Unintended Consequences on Health Buckeye Growth Partners
    25. 25. 2525 Buckeye Growth Partners Buckeye Growth Partners 69 year old truck driver Photoaging - Sun exposure
    26. 26. 2626 Buckeye Growth Partners Buckeye Growth PartnersBreast Cancer - Rising Incidence on a Global Scale Obesity & exercise Early puberty Older pregnancies Hormones, & Pesticides Alcohol & Smoking
    27. 27. 2727 Buckeye Growth Partners Buckeye Growth Partners Personalized Medicine
    28. 28. 2828 Buckeye Growth Partners Buckeye Growth Partners Personalized Medicine Health INFORMATICS
    29. 29. 2929 Buckeye Growth Partners Buckeye Growth PartnersAgenda Revolutionizing & Personalizing Global Health 1 2 3 State of Health Personalized Health – Molecular Revolution Inspiring Disruptive Innovation – Di5
    30. 30. 3030 Buckeye Growth Partners Buckeye Growth PartnersPersonalized Health – Asymptomatic Medicine… Source: http://www.slideshare.net/jcanton/future-of-health-care-presentation Probability Of Disease Personalized Medical Intervention Personalized Lifestyle Modification Genes Biomarkers Proteomics SNPs Environmental Impacts Healthier Longer Lives Transform Sick Care into Healthcare
    31. 31. 3131 Buckeye Growth Partners Buckeye Growth Partners GLOBAL HEALTH REVOLUTION Extend Productive Life Economically 77 100
    32. 32. 3232 Buckeye Growth Partners Take Away Goes Here Translating Genomics into Precision Medicine Structure of genomes Biology of genomes Biology of disease Advancing medicine 1990-2003 Human Genome Project 2004-2010 2011-2020 Beyond 2020 Source: Nature v.470, p.204 (2011)
    33. 33. 3333 Buckeye Growth Partners Buckeye Growth Partners Commercial Prospects for Genomic Sequencing Technologies Nature Reviews in Drug Discovery (May 2013)
    34. 34. 3434 Buckeye Growth PartnersSuccessful Genomics – Marketed Drugs & in Clinical Trials DRUG TARGET COMPANY INDICATION STATUS Xalkori EML4-ALK NSCLC FDA Approved in 2011 Zalboraf BRAF kinase Melanoma FDA Approved in 2011 Benlysta BLYS Lupus FDA Approved in 2011 Odanacatib Cathepsin K Osteoporosis Stopped early due to success Atacicept BLYS Receptor Lupus PII/III AMG-785 Sclerostin Osteoporosis PIII LX4211 SGLT1 Diabetes Completed PII, showed POC LX1032 TPH1 Carcinoid Syndrome Completed PII, showed POC Mapatumumab TRAIL-R1 Cancer PII Apomab TRAIL-R2 Cancer PII Dulanermin TRAIL Cancer PII LX-2931 S1P Lyase Rheumatoid Arthritis PII LX-1033 TPH1 IBS PII OC-000459 CRTH2 R Asthma PII DG-041 Prostanoid EPR PAD PII Source: Nat. Rev. Drug Disc. (Jan, 2011) These drugs would not exist had it not been for genomic data This is the tip of the iceberg, since it takes 10-15 years to develop a drug
    35. 35. 3535 Buckeye Growth Partners Buckeye Growth Partners Propelling personalized medicine through MDx Profound Growth of Molecular Test Scope and Availability Source: www.genetests.org Updated as of 9/4/2012 Genetic tests for 2748 diseases in 622 CLIA labs in the US
    36. 36. 3636 Buckeye Growth Partners Biomarker Tests to Improving Efficacy / Safety $2B $4B $5B REQUIRES biomarker test for 26 approved drugs RECOMMENDS biomarker test for 90 approved drugs
    37. 37. 3737 Buckeye Growth Partners “A major breakthrough in metastatic melanoma treatment.” NEJM Editorial, August 26, 2010 “We have never seen 80% response rate in melanoma. This is remarkable.” Paul Chapman, M.D., Memorial Sloan-Kettering Source: Flaherty et al., NEJM (2010) Genomics-Enabled Breakthrough for Melanoma 81% metastatic melanoma patients with BRAF (V600E) mutation responded to treatment Precision Medicine Breakthrough BRAF V600 Test BEFORE AFTER +
    38. 38. 3838 Buckeye Growth Partners Buckeye Growth Partners Dumb Cancers • Single dominant mutation • Small mutation load • Monotherapy is effective • Resistance rare, late, same pathway Smart Cancers • Multiple mutational divers • Large mutational load • Multi-targeted therapy required • Resistance common, early Sledge, G. ASCO Presidential address, 2011 Stupid and Smart Cancers
    39. 39. 3939 Buckeye Growth Partners Buckeye Growth Partners Gaddy Getz, Broad Institute 2011 Lung cancer has high rate of somatic point mutations
    40. 40. 4040 Buckeye Growth Partners Epigenetics Only 20% of disease linked to germ line mutations Science (2010) Diet Drugs Infections Life-Style Stress Radiation Pollution Internal Chemical Environment Xenobiotics Inflammation Preexisting disease Lipid peroxidation Oxidative stress Gut flora Environment Linked to Explosion in Disease Epidemic of Chronic Disease Emerging as key link between environment & NCD epidemic
    41. 41. 4141 Buckeye Growth Partners Buckeye Growth PartnersGene Expression in Monozygotic Twins Javier and Carlos 6 years old Anna Marie and Clotilde 66 years old Yellow = concordance http://www.pbs.org/wgbh/nova/body/epigenetics.html 50k Person Sister & Epi-Twin Studies 70+% of Health linked to Environment
    42. 42. 4242 Buckeye Growth Partners Buckeye Growth Partners  WHO estimates 6m deaths from smoking and 0.6M deaths from SHS  ¼ of SHS deaths are children, ½ are women  Smoking alters methylation patterns in epigenome 20 year - 40,000 patient study to examine effects of direct and second hand smoking (SHS) One Billion Smokers Globally Epigenetic effects of Smoking seven automated systems
    43. 43. 4343 Buckeye Growth PartnersEpigenetic changes in tumor progression Increased Histone-modification imbalance Increased frequency of hypermethylation Decrease in total DNA methylation content
    44. 44. 4444 Buckeye Growth Partners Buckeye Growth Partners Human Microbiome - “The Second Human Genome” Our bodies contain >100x more unique bacterial genes than human genes Asthma Atopic dermatitis Colorectal cancer Kidney stones Periodontitis Psoriasis Obesity Irritable bowel disease Crohn’s disease healthy micobiome perturbed… Science Translational Medicine (June 2012) Trends in Genetics (January 2013) …immune and metabolic disease ensue Linked to Human Microbiome
    45. 45. 4545 Buckeye Growth Partners Buckeye Growth Partners Microbiome Research is Rising Exponentially Explosive Growth in Microbiome Research Publications since 2003 Nature Biotechnology (April 2013)
    46. 46. 4646 Buckeye Growth Partners Buckeye Growth Partners Fact or Fallacy
    47. 47. 4747 Buckeye Growth Partners Buckeye Growth Partners ‘Needing’ forms the basis of addiction – you can’t turn it off anymore
    48. 48. 4848 Buckeye Growth Partners Buckeye Growth PartnersFACT -- Defining food addiction Robert Lustig Food Provocateur
    49. 49. 4949 Buckeye Growth Partners Buckeye Growth Partners7 Criteria of Addiction: 1 2 3 4 5 6 7 Tolerance – need more substance to get the same effect Withdrawal – anxiety, depression, tremors Bingeing Desire or attempts to cut down or quit Cravings or seeking Interference with life Use despite negative consequences Emotional Trigger Guilt Craving RitualUsing Addiction Cycle Addiction = 3+ of 7 criteria defined by the American Psychological Association
    50. 50. 5050 Buckeye Growth Partners Buckeye Growth PartnersThe Key Players that Determine our Metabolic Fate DOPAMINE (neurotransmitter) LEPTIN …the result is metabolic disease Work well when in balance, BUT when things go wrong… RESISTANCE RESISTANCE ADDICTION INSULIN
    51. 51. 5151 Buckeye Growth Partners Buckeye Growth Partners All Calories Are NOT Equal Food as a Hormone
    52. 52. 5252 Buckeye Growth PartnersAll Calories are NOT Created Equal Proteins require 10-20 times as much energy to digest as fats Source: Science. (February 2013)
    53. 53. 5353 Buckeye Growth Partners Buckeye Growth PartnersA Big Mac, Large French Fries & Large Coke The “typical” fast food meal is a recipe for cardiovascular mayhem 1360 Calories Total 520 Calories from Fat 89% Daily Total Fat (58g) 89% Daily Total Cholesterol (80g) 63% Daily Total Carbohydrate (190g) 24 teaspoons of sugar (95g) 1/4 the fat as a block of lard… …and 1/2 a cup of sugar
    54. 54. 5454 Buckeye Growth PartnersAll Calories are NOT Created Equal More energy is needed to digest raw foods Source: Science. (February 2013)
    55. 55. 5555 Buckeye Growth PartnersCooking increases Body Mass Index Source: PNAS (Npvember 2011) Changes in BMI on sweet potato diets Raw Whole Raw Pounded Cooked Whole Cooked Pounded { { Raw Cooked
    56. 56. 5656 Buckeye Growth PartnersAll Calories are NOT Created Equal Fruit fiber mitigates most of the negative effects of sugar Source: Science. (February 2013)
    57. 57. 5757 Buckeye Growth Partners Buckeye Growth PartnersOur Craving for Sugar has Consequences The craving for sugar has contributed to the diabetes epidemic Analysis of 175 countries shows: Extra 150 cal/day in sugar 1.1% boost in T2D Extra 150 cal/day in all food0.1% boost in T2D Implies sugar impacting diabetes more than obesity
    58. 58. 5858 Buckeye Growth Partners The Mediterranean Diet the Evidence is In!
    59. 59. 5959 The Mediterranean Diet – the Evidence is In! For the first time ever, the protective effect of the Mediterranean Diet was examined in a large, randomized trial.
    60. 60. 6060 Confidential The Mediterranean Diet – the Evidence is In! 7,447 people with CVD risk (but no prior CVD) were split into three groups: Control Group: Low Fat diet Group 1 Mediterranean diet PLUS given free extra virgin olive oil Group 2 Mediterranean diet PLUS given free nuts
    61. 61. 6161 Buckeye Growth PartnersThe Mediterranean Diet – the Evidence is In! Control Group Low Fat Diet Group 1 MD + Olive Oil Group 2 MD + Nuts 30% LESS LIKELY TO HAVE SUFFERED A CVD EVENT – AFTER 4 YEARS
    62. 62. 6262 Buckeye Growth Partners Buckeye Growth PartnersHormones Determine Our Metabolic Fate When things are working “properly” we maintain a normal healthy weight David on a Mediterranean Diet I’m full Leptin (adipose tissue) • Level: LOW Dopamine (brain) • Level: LOW Insulin (pancreas) • Level: LOW
    63. 63. 6363 Buckeye Growth Partners Buckeye Growth PartnersWhen Key Players Go Bad… Hormone resistance – and metabolic disease David on a High Sugar and Fat Diet Hungry & Lazy Keep Eating Leptin (adipose tissue) • Level: HIGH Dopamine (brain) • Level: HIGH Insulin (pancreas) • Level: HIGH
    64. 64. 6464 Buckeye Growth Partners Buckeye Growth PartnersAgenda Revolutionizing & Personalizing Global Health 1 2 3 State of Health Personalized Health - Molecular Revolution Inspiring Disruptive Innovation – Di5
    65. 65. 6565 Buckeye Growth Partners Buckeye Growth Partners Framework to Inspire Disruptive Innovation – Di5 Capital Transitions Greater Purpose & Vision Governance & Culture Market Immersion & Strategy Innovation & Commercialization
    66. 66. 6666 Buckeye Growth Partners Revolutionize Global Health Innovation Asymptomatic Personalized Sustainability United Purpose: Eradicate Disease - Cancer
    67. 67. 6767 Buckeye Growth Partners Chris Maki is ALL IN! For my three little girls …
    68. 68. 6868 Buckeye Growth Partners Buckeye Growth Partners Chris, Allie and Tommy will never be forgotten Contributed photo
    69. 69. 6969 Buckeye Growth Partners Buckeye Growth PartnersBridging The Technology Adoption Gap Win – Win Technology PatientD I S E A S E S TRANSLATION Government, Hospitals, Pharma and Tools
    70. 70. 7070 Buckeye Growth Partners TECHNOLOGY THEMES Imaging & Pathology Biomarkers Mdx, Cdx Cellular Systems Molecular Analysis Biologics Vaccines Targeted Small Molecule INFORMATICS Personalized Health Solect Solar
    71. 71. 7171 Buckeye Growth Partners Buckeye Growth Partners Need relevant predictive models Biomarkers are enabling translation Cancer, Cardiac, Stroke and Diabetes Current industry trends: 99%+ attrition $1B+ / 15 years Small AnimalCellDNA, RNA Protein HumanTissue The Challenge Facing Our Customers: In Vitro In Vivo TRANSLATION
    72. 72. 7272 Buckeye Growth Partners Buckeye Growth Partners In Vitro In Vivo Small AnimalCellDNA, RNA Protein HumanTissue Top Challenge Facing Our Industry: TRANSLATION
    73. 73. 7373 Buckeye Growth Partners Buckeye Growth Partners Pre-ClinicalClinical Goal COST OF TESTING DATAQUALITYDisruptive Innovation in vitro to in vivo to human Small Animal Cell DNA, RNA Protein Human Tissue Solect Solar
    74. 74. 7474 Buckeye Growth Partners Buckeye Growth PartnersCapturing Value through Hybrid Model CONFIDENTIAL
    75. 75. 7575 Confidential Unification of 25 Companies Life Sciences & Technology
    76. 76. 7676 Buckeye Growth Partners Advances in Sequencing Technology Enable Clinical NGS Cost Prohibitive Cost Effective “Cancer will most likely be transformed by next generation sequencing.” Eric Topol, The Creative Destruction of Medicine
    77. 77. 7777 Buckeye Growth Partners Key Bottlenecks in Next Generation Sequencing Source: The Global Outlook for Next Generation Sequencing: Usage, Platform Drivers & Workflow (2011) BioInformatics LLC. Survey asking 267 scientists currently using Next Generation Sequencing. Sample Prep Informatics
    78. 78. 7878 Buckeye Growth PartnersMolecular Tools Creating Sea Change of New Applications Food ID Agrogenomics Human Genomics Infectious Disease Inherited Disease Epigenomics Transcriptomics Cancer Diagnostics Parental Testing Pathogen Detection Dating Consumer Genomics Food and Environment Neonatal Testing Livestock Breeding Fishery Mgmt
    79. 79. 7979 Buckeye Growth Partners Geospiza LIMS and OmicsOffice Visualization NGS Sample Prep Workflow Solutions LabChip XT • Automated DNA Fractionation and Sizing NGS Workstation Post PCR Isolate Sample Fragment & Sizing Generate Library Quantify Sample Sequence Analyze LabChip GX • HT Bioanalyzer-like QC for DNA and RNA NGS Workstation • Automated High- throughput Sequencing Sample Preparation Molecular Biology Workstation • Nucleic Acid Extraction MBW DS XT GX NGS XT GX NGSW Geospiza LabChip DS • UV-Vis DNA/RNA Quantification Sequencing Service Benefits – Agnostic Protocols • Smaller samples - Better quality • Reduced bias - Higher throughput • Lower costs and Informatics linkages
    80. 80. 8080 Buckeye Growth PartnersCustomers, Partners & Advocates AGBT 2012 AGBT 2011 *not a comprehensive list, over 500 NGS customers AGBT 2013
    81. 81. 8181 Buckeye Growth PartnersMolecular Tools Creating Sea Change of New Applications Food ID Agrogenomics Human Genomics Infectious Disease Inherited Disease Epigenomics Transcriptomics Cancer Diagnostics Parental Testing Pathogen Detection Dating Consumer Genomics Food and Environment Neonatal Testing Livestock Breeding Fishery Mgmt
    82. 82. 8282 Buckeye Growth PartnersCancer Treatment Trends at 2013 AACR Early Detection & Predisposition Heterogeneity & Resistance Combination and Immune therapies Non-invasive and frequent samples
    83. 83. 8383 Buckeye Growth Partners More Testing with Smaller Samples NGS Multiplex Assays CTC Imaging Tumor Section Core Biopsy - FNA Single Cells More Testing Smaller Samples
    84. 84. 8484 Buckeye Growth Partners Buckeye Growth Partners Next Gen Pathology Imperative to Embrace the Sequencing / Imaging Revolution
    85. 85. 8585 Buckeye Growth Partners Buckeye Growth PartnersGenoptix: Advancing Precision Medicine AQUA avoids ~20% ER false negatives Conventional IHC: ER/PR ~20-40% disagr. Her2 ~20% disagr. ki67 no standards Her2 ER ki67 PR (4 slides) Vectra simulated H&EDAPIERPRki67Her2all markersfind tumormeasure proteins ER+ (23%) PR- (4%) Ki67+ (16%) Her2+ (100%) (1 slide)
    86. 86. 8686 Buckeye Growth Partners Buckeye Growth Partnerski67 examples (4 patients w/ diff. morphologies) Pathology today Nearly Impossible to accurately determine % of tumor cells Error rates are 10 – 50%
    87. 87. 8787 Buckeye Growth Partners Buckeye Growth PartnersWe add a tumor marker (red) to guide image analysis. Can’t be done visually Hides nuclei and weakly expressing brown stain But ENABLED with image analysis
    88. 88. 8888 Buckeye Growth Partners Buckeye Growth PartnersinForm generates a tumor mask using pattern recognition
    89. 89. 8989 Buckeye Growth Partners Buckeye Growth PartnersIndividual tumor nuclei are scored pos/neg (blue neg, brown pos)
    90. 90. 9090 Buckeye Growth Partners Buckeye Growth PartnersReliable, automated, objective, accurate scores ki67 positivity: 0% ki67 positivity: 6.4% ki67 positivity: 29.5% ki67 positivity: 8.0%
    91. 91. 9191 Buckeye Growth Partners Buckeye Growth Partners C BA D C A B High AQUALow AQUA Ki67 Heterogeneity Quantitation
    92. 92. 9292 Buckeye Growth Partners Buckeye Growth Partners DAPI PhalloidinKi67 KeratinSignaling 1 Signaling 2 Circulating Tumor Cells: Detect 1 Cancer / 1B Normal cells MGH Chip Radiology: Takes weeks to detect Signaling reflects drug response in days 6-color signaling assay Vectra
    93. 93. 9393 Buckeye Growth Partners Buckeye Growth PartnersFluorescence-guided surgery example Color Fluorescence Overlay • Nu/nu mouse with 4T1-luc2 tumor model • CatB-680 probe (2nmol/100mL i.v.) given on day 7 • Surgery 24 hrs post injection of probe • Fluorescence imaging reveals residual tumor after primary resection
    94. 94. 9494 Buckeye Growth PartnersMolecular Tools Creating Sea Change of New Applications Food ID Agrogenomics Human Genomics Infectious Disease Inherited Disease Epigenomics Transcriptomics Cancer Diagnostics Parental Testing Pathogen Detection Dating Consumer Genomics Food and Environment Neonatal Testing Livestock Breeding Fishery Mgmt
    95. 95. 9595 Buckeye Growth Partners Buckeye Growth Partners Tests 55 available tests Newborn screening global market opportunity Total 130M births North Americas Births 4M births $125M $750M* $1B$125M Market Opportunity 6 2 4M births Rest of World 122M births Western Europe 30 100%Screened 95% 45% *Assumes ~60% screened, Average 10 tests/child
    96. 96. 9696 Buckeye Growth Partners Buckeye Growth Partners Why Autism?
    97. 97. 9797 Buckeye Growth Partners Buckeye Growth PartnersAmong the last untapped Dx opportunities Clinically important, scientifically overlooked Current genetic tests fall short Opportunity to lead Opportunity to change the lives of children 97
    98. 98. 9898 Buckeye Growth Partners Buckeye Growth Partners What is Autism? 98
    99. 99. 9999 Buckeye Growth Partners Buckeye Growth PartnersWhat are Autism Spectrum Disorders (ASDs)? 99 Impaired Communication Impaired Social Interactions Repetitive Behaviors / Restricted Interests Autism Spectrum Disorders
    100. 100. 100100 Buckeye Growth Partners Buckeye Growth PartnersNo Easy Answer to “What Causes Autism?” 100 5 – 20% Genetics • DNA • Single gene mutations 80% Unexplained • Environmental? • Age of the father? • Events during pregnancy? • Immune response? SynapDx Test • Expression of genes • Multiple sources of evidence
    101. 101. 101101 Buckeye Growth Partners Buckeye Growth PartnersThe Journey is Long & Time Matters 101 19 months or earlier Parents’ First Concern ~4.5 years Average Age of ASD Diagnosis Get in line for Evaluation at Center ~3.5 years Source: www.cdc.gov, www.iancommunity.org; SynapDx Parent Survey Sept 2010  486,000 children suspected of developmental delay annually in US  A third of patients get diagnosed at autism centers  50,000 diagnosed with ASD annually  Lifetime costs per ASD patient $3.2M
    102. 102. 102102 Buckeye Growth Partners Buckeye Growth PartnersEarly Detection Improves Outcomes “20% of children have the autism label removed when behavioral therapy is begun early.” Geri Dawson, PhD, Chief Science Officer, Autism Speaks, Speaking at an NIH-sponsored biomarker meeting 2011 Every dollar spent on SynapDx testing could save $70 102
    103. 103. 103103 Buckeye Growth Partners Buckeye Growth Partners 80% of children with autism are missed before age three Visit Pediatrician Diagnosed before age 3 (2) = Suspected of Autism Spectrum Disorder (ASD) = Autism Spectrum Disorder Diagnosis Missed before age 3 (8) No evaluation before age 3 Referred and evaluated by age 3
    104. 104. 104104 Buckeye Growth Partners Buckeye Growth Partners SynapDx test could identify 90% of children by age three Get SynapDx Test Missed before Age 3 (1) Diagnosed before age 3 (9) Lower Risk test result Elevated Risk test result
    105. 105. 105105 Buckeye Growth Partners Buckeye Growth Partners SynapDx: Accelerate Time to Diagnosis 105 Autism CenterPediatrician Suspected Patient Other Specialists / Therapists Wait until high index of suspicion Precious Time Lost Today With SynapDx Test Autism CenterPediatrician Suspected Patient ASD Dx ASD Dx 4.5 yrs old 2 yrs old
    106. 106. 106106 Neonatal Diagnosis in Two Days: STAT-Seq “A lot of people are going to realize that this is the future.” Richard Gibbs, Baylor College of Medicine 50 hours to diagnosis for $13,500 One test – 600 rare diseases CONFIDENTIAL
    107. 107. 107107 Buckeye Growth Partners Buckeye Growth Partners We are building ridiculously small, and elegantly simple purpose-built products based on remarkable mass spectrometry technology. From security and defense to life science research and environmental monitoring, bringing MS capability from the centralized lab to the point of need. Answers whenever and wherever you need them.
    108. 108. 108108 Buckeye Growth Partners// Buckeye Growth Partners Centralized Model of Scientific Research Strategic Research Routine Analysis “Core Facility” Routine Analysis
    109. 109. 109109 Buckeye Growth Partners// Buckeye Growth Partners The „Personal Mass Spec‟ Disrupts Scientific Workflows “Core Facility” Strategic Research  Small Footprint  Simple Operation  Robust  Adequate Performance  Affordable  Broadest Application Platform Legacy Mass Spec  Large Size  Expert Operation  Maintenance  Excess Performance  $150K- $1M+ price  Expansive $2.4Bn/yr Market Biotechnology & Medical Research Pharmaceuticals DiagnosticsAgriculture
    110. 110. 110110 Buckeye Growth Partners Human Health Environmental Health Side Effects Dosage Medicine Symptoms Biomarkers Food Pathogens Chemicals Water Safety Air Quality Pollution Exercise Nutrition My LifePad – Integrating Information for Personalized Health
    111. 111. 111111 Buckeye Growth Partners Buckeye Growth Partners N-of-One’s Solutions: Timely  Succinct  Transparent  Clinically actionable  Non-prescriptive N-of-One® Realizing Precision Medicine 12 yo M: Glioblastoma • NGS identified BRAFV600E mutation, more commonly associated with melanoma • Impact: Oncologist petition for vemurafenib (FDA: melanoma) 25 yo F: Breast Cancer • arrayCGH detected high-level Her2 gain in recurrent tumor • Status post mastectomy: disease free • Impact: N-of-One TrialMatchTM identified Her2 vaccine trial 61 yo F: Lung Cancer • Her2/neu mutation detected by DNA MassARRAY • Impact: Successful petition by oncologist for off-label use of Herceptin; patient in remission nearly 2 years 79 yo M: Pancreatic • High-level c-Met expression detected • Impact: N-of-One TrialMatchTM identified cabozantinib trial (FDA approved: thyroid cancer) N-of-One material confidential. Do not distribute
    112. 112. 112112 Buckeye Growth Partners Buckeye Growth PartnersPKI Technology was Instrumental in these Discoveries Pfizer, Sutent (sunitinib) (kidney and stomach cancer) Pfizer, Lyrica (pregabalin) (HIV) Pfizer, Celsentri (maraviroc) (neuropathic pain) Genentech, Zelboraf (vemurafenib) (melanoma, BRAF V600E mutation) Novartis, Tasigna (nilotinib) (CML, chronic myeloid leukemia, Gleveec resistance) Novartis, Zometa (zoledronic acid) (metastasis of breast, lung, prostate and multiple myeloma) Takeda, Rozerem (ramelteon) (sleep disorders) BMS, Sprycel (dasatinib) (CML, chronic myeloid leukemia, Gleveec resistance) SIRTex, SIR-Spheres (yttrium-90) (liver cancer) Cubist Pharma, Cubicin (daptomycin) (S. aureus infections – MRSA treatment) Phase I: Cell Genesys, CG0070 (Bladder and multiple indications) Nereus Pharma, NPI-0052 (multiple myeloma) Cephalon, CEP-26401 (Alzheimer’s & schizophrenia) Millennium, PS-341 (combo) (Non-Hodgkin’s Lymphoma, others) Insert Therapeutics, IT101 (solid tumors) Novartis, CHIR-258 (Metastatic melanoma) Novartis, AEE788 (Advanced Cancers) Phase II,III: Sanofi-Aventis, Aflibercept (Multiple indications) Boehringer Ingelheim, Oldodaterol (COPD) Xencor, XmAb2513 (Hodgkin’s Lymphoma) Neurogen, DAB-452 (Parkinson) EntreMed, Panzem (Recurrent Glioblastoma) FDA Approved In Clinical Trials
    113. 113. 113113 Buckeye Growth Partners Buckeye Growth PartnersAgenda Personalizing Global Health 1 2 3 State of Health Personalized Health – Molecular Revolution Inspiring Disruptive Innovation – Di5
    114. 114. 114114 Buckeye Growth Partners Buckeye Growth PartnersThank You BioForward Vision Team and… Dr. David Rimm - Yale Dr. Laura Macconaill – Dana Farber Dr. Dan Haber, Dr. Long Le, Dr. Mehmet Toner – MGH Dr. Jay Flatly – Illumina Dr. Kevin Knopp, Dr. Chris Petty – 908 Devices Dr. Stan Lapedis - SynapDx Dr. Andrew Barry, Dr. Nate Cosper, Dr. Mark Roskey Dr. Cliff Hoyt, Dr. Brad Rice, Dr. Josh Moho – PKI Dr. Irene Rombel – Biotech Analyst Google Ventures, NorthBridge Partners, General Catalyst, Arch Ventures Buckeye Growth Partners Solect Solar
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