Welcome to the Basel area Over the past 100 years, the Basel area in the Upper Rhine region has grown to become one of the most successful life sciences clusters in the world today – with about 900 com- panies and an annual turnover of 100 billion dollars. The Basel area contributes significantly to making Switzer- land the world’s most competitive economy.* Located at the borders of Germany and France, and with residents coming from over 150 nations, the region pulses with diversity and dynamism. Dynamism and intellectual capacity have made Basel a world- leading center of innovation: nowhere in the world are more patents registered per capita than in the Basel area. Here, dynamism means world-class openness to new ideas, people, and companies. There is a spirit of successful entre- preneurship in Basel that companies moving into the region sense immediately: here they find all of the necessary frame- work conditions for success and growth. The best of quality is available – whether infrastructure, financial sector, services, suppliers, or highly qualified employees. That is why world-leading companies in the pharmaceuti- cals, biotechnology, medical technology, and agribusiness are headquartered in Basel: they invest steadily and strongly in the region. Together with the outstanding quality of life in the region, these excellent success conditions make the Basel area the location of choice for the life sciences industry. Dr. Hans-Peter Wessels CEO BaselArea Business Development * Global Competitiveness Report 2006 – 2007, World Economic Forum, September 26 th 2006
At the center of Europe lies the meeting place ofSwitzerland, France, and Germany. This is the Baselarea, one of the most successful life sciences clustersin the world: with 900 companies achieving an annualturnover of 100 billion dollars.
“In northwestern Switzerland the spirit of entrepreneurship is pervasive. This makes Basel a place for successful investments in the life sciences.” Thomas Straumann, president of the board of Medartis and member of the board of StraumannThe pulse of the life sciences industryEvery industry has a heart, a center, where the pulse of the A heart for the life sciencesindustry beats, generating bursts of energy to the industry For new medications, implants, diagnostics, novel seeds, orthe world over. For the life sciences, this heart beats in Basel. innovative materials to be developed and later successfullyHere the economy, research, government policy, and society introduced on the market, numerous ingredients have to comemove to the rhythm of the life sciences. The life sciences have together. Basel has them all: the latest research, ground-thus become the dominant industry in the Basel area – and breaking technology, and strong business experience comethe Basel area has become one of the most successful life together with ideal framework conditions.sciences clusters in the world. The result of this recipe is success that is rooted in a longThe figures are impressive: tradition: Basel’s silk dye works of the eighteenth century• Life sciences companies in the Basel area achieve an developed into leading chemical companies of the nineteenth annual global turnover of over 100 billion dollars and an and twentieth centuries. And because Basel recognized and annual profit of close to 20 billion dollars. tapped the potential of molecular biology early on, the last• Over 900 companies in the region are active in the life sci- 50 years have seen the development of extremely productive ences. pharmaceuticals, agribusiness, food, and medical technol-• Of the one million people living in the region, about one ogy industries. person out of ten is employed in the life sciences – as a researcher, technician, lawyer, manager, bus driver, Over the centuries, Basel not only became the heart of the plant worker, university professor, or student. And there is life sciences industry but also developed a heart for the life employment growth of about 1,000 to 2,000 new jobs in sciences: for here there is far-reaching good will and support the industry each year. for the life sciences and the industry. The Basel area is a highly attractive location to companies from the world over: year afterDynamic growth is assured: the many companies in the Basel year, Basel welcomes dozens of new firms.area life sciences cluster and the competition among themassure the continuously increasing productivity of the clusterand drive the firms towards excellence.
The Basel area is a vibrant environment for the life sci-ences, with the best conditions for success and growth.Along with global leaders in pharmaceuticals, agribusi-ness, and chemicals, new successful enterprises in thelife sciences are constantly emerging, and more andmore established firms are relocating to Basel.
“The building permit for our new biotechnolgy production center was issued by the authorities in only three months’ time. This rapid and depend- able process is of great benefit for patients, the creation of jobs, and fur- ther development of the Basel area.” Matthias M. Baltisberger, Head of Roche BaselBest conditions for successBasel mirrors the conditions and demands of the world mar- company needs in order to move forward is readily availableket: A company achieving growth here will stand the test in Basel – employees, patent lawyers, investors, suppliers,worldwide. It is no wonder that two of the ten largest pharma- and laboratory space.ceutical companies in the world are headquartered in Basel:Roche and Novartis are located here, only walking distance Consultants,apart. patent lawyers Suppliers Private investors andBasel is also home to many other leading life sciences com- mentorspanies and related branches – large corporate groups, such Investors andas agribusiness world leader Syngenta and chemical compa- IT infrastructure venture capitalnies Ciba, Clariant, and Lonza, as well as medical technologycompanies Straumann and Synthes. In addition, numerous International Researchers transport and personnelforeign global companies have invested strongly in the Basel connectionsarea in recent years: DSM Nutritional Products, Huntsman Office and IndustryAdvanced Materials, and Bayer Consumer Care. laboratory space partnersBasel is also especially attractive to start-ups in the life sci-ences industry. In the last ten years, over 100 young com-panies have emerged, working in bioinformatics, develop- The government authorities actively support new and exist-ing antibodies, or building nanoinstruments. Several of these ing companies: thanks to the authorities’ experience in theyoung firms, such as Actelion, Arpida, Basilea, and Speedel, life sciences, investors are rapidly provided with informationsucceeded within a very short time in putting their shares on the requirements for implementation of their projects. Theon the stock market. Other start-ups stand on the verge of necessary permits are reviewed and granted quickly. Public-completing their IPO. private partnership is a reality here.The right temperature This is evidenced by the steady growth of infrastructure forWhat makes this possible for these companies is not only life sciences and the enthusiastic investors and CEOs. Forexcellent science and convincing business models but also Basel has not only the critical mass for success but also thethe very favorable business environment: Everything that a critical temperature.
Although the region already has over 100 , 000 m 2 inlaboratory space, construction of additional laboratoryspace is ongoing in Basel. Private investors have con-fidence in the market, because each year in the lifesciences alone, 1, 000 to 2 , 000 new jobs are created.
“As a start-up company in Basel, we experienced exceptional support in the university environment but also from the cantonal authorities, and this made our rapid development possible.” Ulf Grawunder, Chief Scientific Officer and Cofounder of 4-AntibodyStrong dynamism drives maximum performanceProbably nowhere in the world is there a higher density of This not only puts everything in immediate proximity but alsoresearch specialists in the life sciences than in the Basel area, enables faster and better coordination of work processes.where close to 10,000 researchers are at work. In addition, at Here, research results go to a plant across the street to bethe universities in the region over 5,000 professors, research- converted to medications.ers, and doctoral candidates work in fields connected withthe life sciences. Despite the already strong presence of the life sciences in the Basel area, accelerated growth of the industry is continuing.These 15,000 people invest more than 1.5 billion dollars per Growth rates of 5 % in annual turnover are the rule.year in research development and represent huge potentialand an enormous knowledge base in the life sciences. This not only continues to attract new companies but also drives the companies already located in Basel to record per-But good research alone does not produce a successful life formance. Each year in Basel, they invest over a billion dol-sciences cluster: many companies have chosen Basel as lars in improvements or in construction of infrastructure fortheir location for all activities – from headquarters to research life sciences.departments to production facilities. Founding team of Actelion (from left): Andre Mueller, Jean-Paul Clozel, Martine Clozel, Walter Fischli, Thomas WidmannIn December 199 a research team formerly at Roche was possible because of the unique environmentfounded the biopharmaceutical company Actelion, in the Basel area. “Here we find everything that wewith the goal to use innovative science for the dis- need for success in the life sciences,” says Jean-covery, development, and marketing of Endothelin Paul Clozel, founder and CEO of Actelion. “Not leastReceptor Antagonist (ERA). Today, Actelion employs a large number of motivated, very well educated,over 1,000 people and is the fastest growing biophar- and experienced employees for management andmaceutical company in the world. This rapid growth research.”
The Basel area as a life sciences and research centeris truly a giant campus for the life sciences: the labo-ratories of the universities, the private research insti-tutes, and the RD departments of the companies to-gether form a knowledge pool that provides impetustowards top productivity each and every day.
“The achievements in research and teaching in Basel have a far-reaching resonance. To this, the university institutes and private research facilities make future-oriented contributions.” Werner Arber, Nobel Prize winner in MedicineA new skyline of research is rising in BaselMüller, Reichstein, Arber, Jerne, Köhler, Tonegawa, Zinker- Four of the top 100 universities are in the Basel areanagel: the names may be unfamiliar to some. But they are The long tradition of success is only possible thanks to inten-all Nobel Prize winners that made their ground-breaking dis- sive research, whether conducted at the leading pharmaceuti-coveries in Basel or are closely associated with Basel. Basel cal companies or at the universities. Basel is the center of anot only has one of the oldest universities in the world but region that has a globally unique density of researchers. Aboutalso a tradition of world-shaking innovation – mainly in the 15,000 highly specialized life sciences researchers work inlife sciences. the region, and there is practically no biomedical research question that researchers in Basel have not made a significantBasel has played an extraordinary role in the history of modern contribution to or are not currently seeking answers to.biology. Did you know that DNA was discovered in Basel?Here Friedrich Miescher extracted the nucleic acids, the Basel also offers a rich pool for the recruiting of young talentchemical substrate of the genetic code, from white blood – after all, four of the world’s best universities are in Baselcells in 1871. Werner Arber, winner of the Nobel Prize in 1978 and the surrounding region, according to the Shanghai Aca-and later president of the University of Basel, discovered with demic Ranking of World Universities. Along with the Univer-his fellow researchers the restriction enzymes and their appli- sity of Basel, these are the University of Freiburg in Freiburgcation to problems of molecular genetics, making him known im Breisgau, the University of Zurich, and the Swiss Federalas the father of genetic engineering. Georges Köhler, winner Institute of Technology Zurich (ETH). Basel’s reputation asof the Nobel Prize in 1983, was the first to construct mono- a knowledge center draws graduate students and doctoralclonal antibodies, conducting his work at the Basel Institute candidates from all over the world. They know that here thefor Immunology. educational opportunities are outstanding and that completing their studies in Basel will open the doors to interesting jobsNot to mention the numerous medications developed in Basel in the life sciences.that have changed the world of medicine and help millionsof patients. 9
The companies and the people of Basel are keen topromote the future of the life sciences in the region:in the coming years, thanks to public investments,Basel will become a center of the nanosciences andsystems biology. Together with new research buildingsfrom companies, Basel area is ensuring that it will con-tinue to take a prominent position on the global re-search map.
The conditions for pharmaceutical industry are ideal in the Basel area. That is why we are making major investments into research, devel- opment, and management at this location.” Michael Plüss, Head Novartis SwitzerlandResearch seminars around the corner Shaping the future todayAs a result, there are strong connections and synergies Such collaborative efforts will continue in the future: sev-between university research and research development eral forward-looking projects have been launched in Baselin industry. Mutual exchange between researchers, whether in recent years. The Swiss Nano Center at the Universityfrom university or industry, is intensive. Day after day, there of Basel, for example, is dedicated, in addition to top-classare dozens of research seminars and lectures. And it is easy basic research in nanoscale science, to applied research infor researchers to attend: the university is such a short dis- collaboration with the life sciences industry. The Center oftance away from the Roche or Novartis laboratories that they Biosystems Science and Engineering of the ETH Zurich inoften choose to walk. Basel, devoted to systems biology, is a pioneering center of its kind in Europe.But the strength of research in the Basel area is also based inthe early and successful investment that was made in basic The industry, too, is investing in the Basel area. Numerousresearch and in new technologies. As early as forty years ago, new research facilities are emerging: The independent bio-the University of Basel recognized the signs of the times and, pharmaceutical company Actelion built ultramodern researchacting on an innovative idea, founded the Biozentrum, the first laboratories in Allschwil. Apart from its newly raised biotechcenter for molecular biology in continental Europe. Together production center Roche is planning a new RD facility andwith the Basel Institute of Immunology (Roche), the Fried- a innovative high-rise building. With its “Campus of Knowl-rich Miescher Institute for Biomedical Research (part of the edge,” Novartis is making its global headquarters into a uniqueNovartis Research Foundation), and further university insti- research, development, and management center.tutes, Basel subsequently became a focal point of researchcollaboration in the life sciences. With these projects, Basel’s impressive research skyline of the 21st century is already taking shape on the horizon. 11
Milestones in research in Basel The University of Basel, Susumu Tonegawa Switzerland’s oldest uni- discovers the genetic versity, is founded in 1460 principle for generation at the instigation of the of antibody diversity in Council of Basel. 1976 (Nobel Prize 1987). Albert Hofmann Erika Böhni develops synthesizes an alkaloid the broad-spectrum from ergot: LSD (1943). antibiotic Bactrim (1969).Friedrich Miescher Andreas Vesalius isis the first to isolate the first to prepare aDNA and characterize it human skeleton for(1869). scientific purposes (1543). Paracelsus (1493–1541), Otto Isler achieves physician and alchemist, synthesis of vitamin A revolutionizes the treat- (1947). ment of wounds and does pioneering work in the use of chemicals in medicine.Georges Köhler and Werner Arber isCésar Milstein describe awarded the Nobel Prizein 1975 the hybridoma in 1978 for his discov-technique for the pro- ery of the restrictionduction of monoclonal enzymes.antibodies of monoclonalantibodies (Nobel Prize1984).
Innovative products from Basel-based companies since 1999 2006 Lucentis ® for age-related macular degeneration; NovartisMax Hartmann synthe-sizes Coramin (1924). 2005 PureHeart ™ personal size, seedless watermelon; Syngenta SLActive oral implant with surface which halves oridnary healing times; Straumann 2004 Avastin ® for colorectal cancer; Roche Emselex ® for urinal incontinence; NovartisJean François Borel Tarceva ® for non-small cell lung cancer; Rocheand Hartmann Staehelin 2003 Bondronat ® for osteoporosis; Rochedevelop the firstimmunosuppressant Certican ® for organ transplantation; Novartisagent (Sandimmun) in1970. Emdogain ® easy to use oral tissue regeneration; Straumann Fuzeon ® for HIV infections; Roche Stalevo ® for Parkinson’s disease; NovartisTadeusz Reichsteinis the first to synthesize Zavesca ® for type 1 Gaucher disease; Actelionvitamin C (1933) and lateralso isolates cortisone 2002 Famvir ® for herpes simplex infections; Novartis(Nobel Prize 1950). Xolair ® for asthma; Novartis 2001 Callisto ® maize herbizide; Syngenta Pegasys ® for hepatitis C; Roche Tracleer ® for pulmonary arterial hypertension; Actelion Valcyte ® for retinitis caused by CMV; Roche Zelnorm ® for irritable bowel syndrome; Novartis 2000 PMI selectable marker gene system for use in plant biotechnology; Syngenta Starlix ® for diabetes; NovartisFelix Platter is the firstto classify mental ill- Zometa ® for hypercalcemia of malignancy; Novartisnesses (1602). 1999 Comtan ® for Parkinson’s disease; Novartis Gleevec ® for chronic myeloid leukemia; Novartis Herceptin ® for breast cancer; Roche Tamiflu ® for influenza infections, Roche 1
With the growing multinational community in the Baselarea, the capacities of the international schools are incontinual development: four schools offer internation-ally recognized curricula. And the quality level is high,for Switzerland has one of the best school systemsworldwide and is regarded as a pioneer and model forpublic schools.
“The only thing we miss is American mayonnaise” Keri and Bill Hinshaw and their two sons have lived in their the language of instruction is English, but German is taught to lovely single family house in Pfeffingen, near Basel, for two all pupils by native German speakers. Many of the Hinshaws’ and a half years now. “We have lived in a lot of places and we friends send their children to the International School Basel found a great house that feels like home in the idyllic hills of (ISB), but as Keri explains, “We wanted our boys to learn Ger- Switzerland.” says Bill. The family moved to Switzerland from man in preschool and kindergarten.” The school is very flexible New Jersey, because Bill, a marketing specialist, found an and responsive to parents’ needs and wishes, says Keri. Kai attractive position at Novartis. and Ronan had no difficulties adjusting: “Both of our boys are very happy at the school.” Keri herself has hired a German Bill is from Tennessee, Keri from Wisconsin. Neither Bill nor teacher and is taking private lessons. She has a challenge to Keri is a born city dweller, both coming from more rural set- practice her German, however, because everyone in Basel tings. While Bill would have enjoyed living in a city environ- immediately answers her in English. Even in the shops. ment, the couple chose to settle in the countryside for the benefit of their children Kai (6) and Ronan (4). “And because Don’t the Hinshaws miss anything at all in Switzerland? “Yes, we can hike, bike and jog right outside our house,” adds the we do,” says Keri, laughing, “We miss American mayonnaise, Novartis manager. pancake syrup, and the huge selection of breakfast cereals and cream cheeses available at American supermarkets.” But Safe, clean, and wonderful for children she likes Swiss cuisine a lot and enjoys shopping in France Despite every conceivable kind of help from Novartis and or Germany: “Shopping in Alsace or Südbaden is like a mini- useful tips from Swiss acquaintances, there were also a few vacation.” surprises for Keri and Bill when they first moved here – and mainly positive ones: When they saw a six-year-old boy travel- Paris, Milano, or Vienna for the weekend ing by tram alone one day, they immediately asked him if they You can feel the Hinshaws’ enthusiasm as they list all the could be of help. But the boy needed no assistance and was advantages of the Basel area, mentioning the public trans- not searching for his mother; he was taking the tram to school, portation that takes them to every corner of the region and happily and on his own, as he did every day. “That would be the museums in Basel that their children so enjoy. The fact unthinkable for a child of that age in the United States, the that the museums of Paris, Vienna, or Amsterdam are within safety of Switzerland is very impressive.” fast and easy reach is another of the advantages of the area. Bill: “It is an unbelievably good experience for us to live in the This and other experiences were very convincing to the Hin- heart of Europe and to be able to travel to Milan, Venice, or shaws: “Switzerland is safe and clean and a paradise for Vienna for a long weekend.” children.” Returning from their last vacation in the United States, their older son said, “It’s good that we’re back home The Hinshaw family ideally would like to live in Switzerland in Basel.” for five years and then move again. But they do not want to live abroad forever. Keri: “We want Kai and Ronan to be able Flexible, international schools to spend a part of their youth in America, together with our Keri Hinshaw is a trained physiotherapist, currently at home families and friends.” with the children. Mornings, she takes the two boys to school at Rhein International Academy (RIA). The private school is But for now they want to stay where they are: in their happy specifically designed for the needs of international children; “home” in Pfeffingen. 1
Life Sciences in the Basel area*Swiss companies4-Antibody Chemoforma Konapharma SantheraActelion Chemspeed Lipomed SchweizerhallADD Technologies Cimex Lonza SenTecAnklin CIS Pharma Lubapharm SkanArpida Concentris Medartis SolviasBachem Confarma Mepha Sotax Basilea Covalys MondoBiotech SpeedelBio Concept Diagene Mundipharma StraumannBiolytix Doetsch Grether Necura Pharmaceuticals Swiss BioAnalytics Biopur Drossapharm Nitec Pharma Swiss Pharma ContractBioreba EyeSense Novartis SyngentaBioWay Genedata OncoScore SynphaBaseBMA Biomedicals Herbonis Pentapharm SynthesbSys Hesperion Permamed Thommen MedicalBuhlmann Laboratories Infors HT Phares Drug Delivery TillottsBureco Inotech Polyphor TLT Medical Camlog InPheno RCC Ltd. VitaplantChemgineering Jungbunzlauer Roche Weleda Foreign companiesAntares Pharma Divi’s Laboratories Knoll (Abbott) Robapharm (Pierre Fabre) USA India USA FranceBayer Healthcare Dr. Reddy’s Kontron Medical (Fukuda) Schwarz Pharma Germany India Japan Germany Beiersdorf DSM Nutritional Products LSMW Shogoo Pharmaceuticals Germany Netherlands Germany JapanBioFocus DPI EUCRO Merck Biosciences SkyePharma UK Germany Germany UKCanyon Pharma Elsevier MDL Merz Symyx USA USA Germany USACarbogen AMCIS (Dishman) Evolva Novozymes Teva Pharma India Denmark Denmark IsraelCochlear Gebro Pharma Quintiles Valeant Australia Austria USA USAClinalfa (Merck Biosciences) Genzyme Pharmaceuticals ResMed Zeptosens (Bayer) Germany USA Australia GermanyInstitutionsUniversity of Basel Friedrich Miescher Institute Center of Biosystems, ETHUniversity of Applied Sciences Swiss Tropical Institute Are you interested in the Basel area?If you are considering setting up business in the world’s finest BaselArea Business Developmentplace for life sciences, we are happy to help. BaselArea pro- Aeschenvorstadt 36 4010 Basel Switzerlandvides advice and active support, for a smooth and successful Phone +41 61 295 50 00 Fax +41 61 295 50 09start. Our services are free of charge. BaselArea is sponsored firstname.lastname@example.org the Cantons of Basel-Stadt and Basel-Landschaft andmajor business associations and unions. www.baselarea.ch* Incomplete list without distributors, consultancies and finance
Freiburg France Germany MulhouseInternational Basel areaBasel is Switzerland’s third-largest city. It is also a Rhinehighly cosmopolitan city: not just as the center of Baselan area of 800,000 people living in Switzerland, Ger-many and France, but also as home to citizens of Zurichsome 10 nations. As a large number of leading global BaselAreacompanies have their headquarters in the Basel area,the region also attracts highly skilled specialistsand their families from the widest possible variety Switzerlandof countries. BernThe Basel area especiallystands for ...… a highly developed and productive economyTotal population Basel area 460,000City of Basel 180,000Percent international immigrants over 0%International residents over 10 countriesFull-time employees 20,000… a strong life sciences cluster … outstanding productivity of life sciences companiesContribution of life sciences sector to regional GDP 2004 Index of productivity per hours worked in life sciences companies Basel Basel London London Munich Munich San Francisco San Francisco Boston Boston 0 3 6 9 12 15 0 20 40 60 80 100 120 Source: BAK Monitoring Life Sciences Locations Source: BAK Monitoring Life Sciences LocationsFor more information on life sciences in the Basel area please see:www.lifesciences.ch and www.biovalley.ch