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Basic Formal Ontology (BFO) is a small, domain-neutral, upper-level ontology that is used to support integration of domain-specific ontologies in scientific, military, clinical and other areas.
Like Lowe's 4CO, BFO divides reality into particulars and universals. But it replaces 4CO's dichotomy of substantials and non-substantials with a trichotomy of independent continuants, dependent continuants, and occurrents.
I will sketch the BFO ontology and show how it is being used as a starting point for the creation of domain ontologies to support data integration in scientific research.