Healthy Healing Biologist Luisa Ann DiPietro:  Reducing Scarring and Speeding Healing
Luisa DiPietro Optimizes Healing <ul><li>Dentist and biologist DiPietro works to change the way we view healing. </li></ul...
Answer:  No Different types of tissue heal better than others. <ul><li>Skin tissue is more likely to scar than are mucous ...
Stages of Healing
Inflammation in Cells <ul><li>Neutrophils are the first cells to respond to injury </li></ul><ul><li>Macrophages clean up ...
Angiogenesis <ul><li>New vessels grow and cover wound </li></ul><ul><li>New vessels bring oxygen and nutrients to wound </...
Too Much of a Good Thing? <ul><li>Excess inflammation can damage healthy, neighboring tissues </li></ul><ul><li>Excess inf...
DiPietro’s Gnawing Problem <ul><li>As a dentist, DiPietro knew that severe scarring is rare in tissue with mucous membrane...
Knowledge By Comparison <ul><li>Approach #1 :  Compare how lab-grown, human skin and mouth cells respond to injury </li></...
Many Unanswered Questions <ul><li>What causes scarring? </li></ul><ul><li>Why does your mouth scar so much less severely t...
Research Applications <ul><li>Can you think of a new way to prevent scarring? </li></ul>
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  1. 1. Healthy Healing Biologist Luisa Ann DiPietro: Reducing Scarring and Speeding Healing
  2. 2. Luisa DiPietro Optimizes Healing <ul><li>Dentist and biologist DiPietro works to change the way we view healing. </li></ul><ul><li>Healing </li></ul><ul><li>Is a regenerative series of events </li></ul><ul><li>Involves >12 cell types and >100 molecules </li></ul><ul><li>Can go awry </li></ul>Question: Do all types of tissue heal equally well? Photo: Bill Wiegand
  3. 3. Answer: No Different types of tissue heal better than others. <ul><li>Skin tissue is more likely to scar than are mucous membranes </li></ul><ul><li>Slippery tissues inside the nose, ears, mouth, and other body cavities heal faster than skin tissue </li></ul><ul><li>Diseased tissue in arteries may not completely heal </li></ul><ul><li>Wounds in people with some diseases may heal more slowly than those of healthy people </li></ul>
  4. 4. Stages of Healing
  5. 5. Inflammation in Cells <ul><li>Neutrophils are the first cells to respond to injury </li></ul><ul><li>Macrophages clean up debris </li></ul><ul><li>Mast cells induce swelling, warmth, and redness </li></ul><ul><li>All 3 types of cells summon more immune system cells </li></ul>Wound cells Photo: Copyright Dennis Kunkel Microscopy, Inc.
  6. 6. Angiogenesis <ul><li>New vessels grow and cover wound </li></ul><ul><li>New vessels bring oxygen and nutrients to wound </li></ul><ul><li>Proteins grab the edges of wound and close it, forming a protective mesh </li></ul><ul><li>Excess new vessels die off </li></ul>Scar
  7. 7. Too Much of a Good Thing? <ul><li>Excess inflammation can damage healthy, neighboring tissues </li></ul><ul><li>Excess inflammation can be life-threatening </li></ul><ul><li>Excess angiogenesis can worsen scarring </li></ul>How does this happen? When is inflammation potentially dangerous? In what types of human cells does this NOT occur?
  8. 8. DiPietro’s Gnawing Problem <ul><li>As a dentist, DiPietro knew that severe scarring is rare in tissue with mucous membranes, such as mouth tissue </li></ul><ul><li>As a biological researcher, DiPietro wants to know why the same is not true of other types of tissue, like skin </li></ul>
  9. 9. Knowledge By Comparison <ul><li>Approach #1 : Compare how lab-grown, human skin and mouth cells respond to injury </li></ul><ul><li>Approach #2: Compare healing process of injured skin and tongues in mice </li></ul>In vitro experiment In vivo animal experiment DiPietro’s Approaches to Better Understand Healing
  10. 10. Many Unanswered Questions <ul><li>What causes scarring? </li></ul><ul><li>Why does your mouth scar so much less severely than your skin? </li></ul><ul><li>Can we learn from these differences? </li></ul>
  11. 11. Research Applications <ul><li>Can you think of a new way to prevent scarring? </li></ul>
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