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College Medema 1
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College Medema 1

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College Medema 1 College Medema 1 Presentation Transcript

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  • Cell division (1) cytoplasm nucleus Mitosis G1 phase S phase DNA replication G2 phase Cytokinesis Chromosome Segregation (Karyokinesis)
  • Cell division (2) DNA replication Chromosome segregation
  • time activity Cell division (3) replicate replicate replicate divide divide divide
  • Lessons from cell fusion (1) G1 phase Mitosis M-phase Promoting Factor
  • Lessons from cell fusion (2) S phase Mitosis M-phase Promoting Factor G1 phase S-phase S-phase Promoting Factor
  • Lessons from cell fusion (3) G1 phase G2-phase M-phase Delaying Factor S phase G2-phase DNA Re-replication Inhibitor
  • Interdependence DNA replication Chromosome segregation
  • Cyclins (1) cyclins MPF MPF mitosis mitosis interphase cyclins
  • time activity Cyclins (2) Replicate: Cyclin E Divide: Cyclin B Replicate: Cyclin E Divide: Cyclin B Replicate: Cyclin E Divide: Cyclin B
  • Cyclin/cdks G1 S M G2 cdk cdk cyclin cyclin G1 cyclin mitotic cyclin
  • Cyclin/cdks in mammals Cyclin D G2 S G1 S M G2 Cdk1 Cdk2 Cdk2 Cdk4 Cdk6 S Cyclin E M Cyclin A Cyclin B
  • Kinase activity G1 G2 S M Cyclin B /cdk1 (1) Cyclin B CyclinE-cdk2 CyclinA-cdk2 CyclinB-cdk1 Protein level
  • Cyclin B /cdk1 (2) CycB APC Ub Ub Ub Ub Ub Spindle Checkpoint APC E2F CycA cdk2 CycA CycB NF-Y B-Myb FoxM1 Kinase activity G1 G2 S M CyclinE-cdk2 CyclinA-cdk2 CyclinB-cdk1 Cyclin B Protein level
  • Cdk activation (1) Cyclin B Wee1 Cdc25 Cdk1 P P P CAK
  • CyclinB - kinase activity Cdk activation (2) Cdk1 P P Wee1 P CAK Cdc25 + + P P
  • Bistability (1) Cyclin B1 levels Cyclin B1-Cdk1 activity
  • Cyclin Bistability (2) Cdk P P Wee1 P CAK Cdc25 Plk1