Questions asked in previous years from solubility chept

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Questions asked in previous years from solubility chept

  1. 1. Questions asked in previous years• (1)What are application of solubilization technequies & how will you compare the effeciency of each technequies with respect to its application(2008)• (2)Cyclodextrin(2008)• (3)What do you mean by fast dissolving product?Write mechanism for obtaining these product(2008)• (4)Advantages & disadvantages of different technequies to improves solubility of API(2005;08)• (5)factors affecting solubility & dissolution rate(2006;LM-06)• (6)How will you carried out solubilization study in preformulation(06; LM-06)• (7)Explain Dankert’s models of soubility(2006; LM-06)• (8)Elimination rate differ in various condition –Justify the statement using Michales Menton equation(2006; LM-06)• (9)With respect to drug-cyclodextrin complexation Explain the calculation of USD with suitable example(2005;LM-04)• (10)Describe the different method of preparation of beta-cyclo dextrin inclusion complex(2004) 1
  2. 2. (1)Michaelis Mentons equation(LM-08)(2)How vitamin use as solubilizer(LM-04;07)(3)Discuss use of salt formation ,surfactant,adducts,clathrates in solubilization of poorly soluble drug(LM-07)(4)What make drug insoluble & why we want to solubilized them?(LM 06)(5)How can you express solubility in different term?(LM-06)(6)What do you mean by combined technequies of solubilization Explain one of them in detail(LM-06)(7)Give conventional & patent technequies of getting fast dissolving product(LM-06)(8)Discuss factor to be considered in selecting PH for adequate solubility of API(LM-06)1. Micronization as a solubilization technequies(LM-04)(9)Which are newer approaches in micellar system(LM-04)(10)Bioavailability of poorly soluble API is challeng to formulation scientist-Discuss physical & chemical modification to solve this (LM-04)
  3. 3. (11)SHORT QUESTIONS:-1. Explain complexation constant(LM-04)2. Fast dissolving product (LM-04)3. Quick dissolving films(LM-04)4. Combined effect of PH & polysorbate with cyclodextrin on solubilizationwith suiable example(LM-04)

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