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gaba neurotransmitter …

gaba neurotransmitter
function & mechanisms

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  • 1. GABA Aya Ali 431203717 γ-Aminobutyric acid
  • 2. Outline : GABA:  Mechanism of action  Synthesis.  Receptors .  Function .  Deficiency.  Disease related .  Conclusion
  • 3. GABA GABA acts at inhibitory synapse in the brain by binding to specific transmembrane receptor in the plasma membrane of both pre- and postsynaptic neuronal processes. It is most highly concentrated in the substantia nigra & globus pallidus nuclei of the basal ganglia, followed by the hypothalamus, the periaqueductal grey matter.
  • 4. Fig (1)
  • 5. Mechanism of Action open chloride receptorschannels induce cellular hyperpolarisation by increasing intracellular concentration of chloride
  • 6. Synthesis of GABA
  • 7. GABA Receptor GABA exerts its effects via two types of receptors: GABA-A and GABA-B receptors
  • 8. GABA-A
  • 9. GABA-B   Activation of presynaptic GABA-B receptors decreases the release of GABA and of different transmitters. Activation of postsynaptic GABA-B receptors modulates the opening of potassium channels, which induces an intracellular potassium exit and consequently a membrane hyperpolarisation.
  • 10. GABA Function     Relieving anxiety. Improving mood. Relieving premenstrual syndrome (PMS). Regulating the release of sex hormones.
  • 11. GABA Functions… cont       Treating attention deficit-hyperactivity disorder (ADHD). Promoting lean muscle growth. Burning fat. Stabilizing blood pressure. Relieving pain. lower elevated blood sugar levels in diabetics.
  • 12. Deficiency of GABA  It has been suggested that a shortage of GABA may cause panic attacks, since an intake of tranquilizers can increase the level of GABA in the body. GABA may also be effective in treating PMS in women.
  • 13. Health problems can GABA Deficiency cause        Insomnia Depression Mood disorders Excessive stress Hypertension Atherosclerosis Motion sickness low levels of digestive enzymes ADHD Epileptic seizures Panic disorders Bronchitis Growth hormone stimulation
  • 14. Reference   http://www.benbest.com/science/anatmind/anatmd1 0.html#gaba http://www.pharmacorama.com/en/Sections/Gaba.p hp
  • 15. Conclusion GABA is an amino acid made in brain cells from glutamate. It functions as an inhibitory neurotransmitter, meaning it blocks nerve impulses. Without GABA, nerve cells fire too often and too easily.