WIDESPREAD PURIFYING SELECTION
ON RNA STRUCTURE IN MAMMALS
Martin A. Smith , Tanja Gesel, Peter F. Stadler, John S. Mattic...
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Widespread Purifying Selection on RNA Structure in Mammals - Martin Smith

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Widespread Purifying Selection on RNA Structure in Mammals - Martin Smith

  1. 1. WIDESPREAD PURIFYING SELECTION ON RNA STRUCTURE IN MAMMALS Martin A. Smith , Tanja Gesel, Peter F. Stadler, John S. Mattick Garvan Institute, Sydney, Australia [m.smith@garvan.org.au] Robust benchmarking Pan-mammalian genome-wide screen SISSIz 2.0 SISSIz 2.0 [+R] RNAz 2.0 >4.2 million high confidence, evolutionarily conserved RNA 2D structure predictions 48% 5% 17% 13% 2% 4% Sensitivity 100% 10% Specificity 13.6% 1% Intergenic 41% Intronic 55% 3% Exonic 3% 8% 2% 3’UTR CDS 5’UTR Non-coding (0.3%) 60% 40% 20% 0% 9.2% 80% >88% of which do not overlap with annotated sequence constrained elements

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