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Chromatin State Analysis in Model Organisms - Djordje Djordjevic
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Chromatin State Analysis in Model Organisms - Djordje Djordjevic

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Description: This slide gives a brief insight into our work at VCCRI on chromatin state analysis in D. melanogaster, C. elegans and Aspergillus nidulans. We use a novel method called …

Description: This slide gives a brief insight into our work at VCCRI on chromatin state analysis in D. melanogaster, C. elegans and Aspergillus nidulans. We use a novel method called Hierarchically-Linked Infinite Hidden Markov Model (hiHMM) developed by our collaborator in Korea, to jointly infer chromatin state across three developmental stages in fly, and to compare chromatin states between species. Analysis of chromatin state can give very detailed insight into important regulatory regions such as enhancers and promoters, and our joint inference allows us to see how the annotation of a shared chromatin states model changes between species and developmental stages.

This slide consists of three figures.

1) A brief graphical illustration of histone modifications.

2) An example of a shared chromatin state signal matrix and paired statistics for three developmental stages in fly.

3) An example of chromatin state in a genome browser and the visible differences in developmentally regulated genes.

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  • 1. Chromatin state analysis in model organisms Djordje Djordjevic, Ho Lab, Victor Chang Cardiac Research Institute We infer chromatin state jointly across multiple species or developmental stages, from histone modification ChIP-seq profiles using an infinite hidden Markov model. As well as identifying important regulatory regions in fly, worm and fungus, there are many interesting biological questions we are addressing. DNA images sourced from: http://www.bio-rad.com/ and www.integratedhealthcare.eu

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