Be the first to like this
BloodChIP is a user friendly database that integrates genome-wide binding profiles of haematopoietic transcription factors (TFs) in primary
human CD34 positive stem/progenitor cells as well as Megakarocytes, SKNO-1 and K562 cell types. It also includes histone profiles from the Human Epigenome Atlas and gene expression of cell types and CD34 fractions.
An interactive web interface allows users to query BloodChIP and ascertain the relative expression level of their genes of interest across normal and leukaemic stem/progenitor fractions. Importantly, the user is then able to associate expression levels in these cell fractions with chromatin accessibility and transcription factor binding profiles in primary human HSPCs to gain insights into the transcriptional regulation of these genes. The database supports exploration and selection based on either genes or transcription factors of interest. All queries, as well as the complete database, can be exported by the user for further data analysis.
Authors: Diego Chacon, Dominik Beck, Jason WH Wong & John E Pimanda