Written Report (BONE)

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  • 1. BONE Chapter 10 A narrative report Submitted by: Bautista, Louis Clyde C. Gatdula, Dave Joseph B. Ong, Charles Adrian P. Santos, Pauleen Ashley R. Torres, Jhoana Marie O.Tria Tirona, Rafaelle Jeanna E. Submitted to:Dr. Marie Antoniette R. Veluz
  • 2. CHAPTER 10: BONEWhat is a bone? A bone is a specialized connective tissue, which consists of intercellular substances and osteocytes. Systematically, it is finally controlled by hormonal factors. Locally it is controlled by mechanical forces including tooth movement, growth factors, cytokines, and piezoelectric conditions. It consists of 67% of inorganic matrix which is a poorly crystallized calcium-deficient Hydroxyapatite crystals (Ca10(PO4)6(OH)2), while 33% is made up of Organic matrix which contains 28% collagen and 5% noncollagenous protein (Osteonectin, osteocalcin, bone morphogenetic protein, bone proteoglycan, bone sialoprotein). The ratio between hard and soft components is sufficient to ensure a degree of elasticity. Bone resists compressive forces best and tensile forces least. There are plenty of functions a bone can perform, and these are the following: Mechanical function includes protection of the internal organs of the body, provides structural framework to keep the body supported, and it provides movement of the body. Synthetic function includes blood production in the bone marrow. This process is called hematopoiesis. Metabolic functions of bone include the storage of important minerals in the body like calcium and phosphorus, storage of important growth factors, and for the storage reserve of fatty acids. The Structural Elements of the bone are the bone cells, bone matrix, sharpey’s fibers, blood vessels, nerves, lymphatic vessels. Bone cells are primarily responsible for the formation, resorption, and maintenance of osteoarchitechture. There are 3 types of bone cells are described with each specific function: Osteoblasts are uninucleated cells that synthesize both collagenous and noncollagenous bone proteins. They are located on the surface of bone or osteoid. Osteoblasts also synthesize the enzyme alkaline phosphatase, which is needed locally for the mineralization of osteoid. When the bone is no longer forming, the surfaces of the osteoblasts become inactive and are called Lining cells. These lining cells retain their gap junctions with osteocytes, creating a syncytium that functions to control mineral hemostasis and ensure bone vitality. Osteoblasts do not divide. They give rise to osteocytes, remain as osteoblasts, or return to the state of osteoprogenitor cells from which they derived. They secrete type I and type V collagen and small amounts of several noncollagenous proteins, and a variety of cytokines. Parathyroid hormone & vitamin D enhance bone resorption at high concentrations but supporting bone formation at
  • 3. lower concentrations, while Calcitonin & estrogen inhibit bone resorption. On the other hand, Glucocorticoids inhibit both resorption and formation of the bone, but primarily formation. Osteoblasts also synthesize a variety of cytokines and growth factors such as Bone morphogenetic protein (BMP), Transforming growth factor beta (TGF-BETA), Insulin-like growth factor, Platelet-derived growth factor (PDGF-AH) and Fibroblastic growth factor beta (FGF-BETA) that help in regulating cell metabolism. Osteocytes are osteoblasts secreted in thebone matrixes that are entrapped in lacunae. Anosteocyte lies in its own lacuna and contacts itsneighboring osteocytes cytoplasmically throughcanaliculi. The processes of adjacent cells makecontact via gap junctions, maintaining the vitalityof osteocytes by passing nutrients andmetabolites between blood vessels and distantosteocytes, regulating ion homeostasis, andtransmitting electrical signals in bone. Osteocytesare responsible for osteolysis or limitedresorption of bone materials at the walls of theosteolytic lacunae and canals, and osteoplasia,the secondary rebuilding of perilacunar bonemineral. They are known to be as the “housekeepers” of the bone since they are activelyinvolved in the maintenance of the bony matrix. Osteoclasts are probably derived from amonocytic-macrophage system, which areresponsible for bone resorption. They are large,multinucleated cells with fine, fingerlike cytoplasmicprocesses and are rich in lysosomes that containtartrate-resistant acid phosphatase (TRAP).Osteoclasts lie in resorption craters known asHowship’s lacunae on bone surfaces or in deepresorption cavities called cutting cones. They possessan organelle-poor, brush-like cytoplasmic borderknown as ruffled border which demarcates the zoneof resorption. The osteoclasts resorbs the bone byfirst attaching themselves to the mineralized tissueand create a sealed environment that is acidified to demineralize the hard tissue. After theexposure to the acidic environment, the organic matrix is broken down by the secretion ofproteolytic enzymes.
  • 4. Bone Matrix Bone matrix is the intercellular substances of bone and consists of organic and inorganic components. The association of these substances gives bone its hardness and resistance. The organic component is composed of:  collagen fibers with predominately type I collagen (95%) which provides tensile strength  proteoglycans that are responsible for compressive strength  matrix proteins  osteocalcin that functions to promote mineralization and bone formation  osteonectin that plays a role in regulating collagen attachment, and  osteopontin, a cell binding protein that is similar to an integrin  Cytokine and growth factors that aid in bone cell differentiation, activation, growth, and turnover. The inorganic component is made up of Hydroxyapatite crystals (Ca10(PO4)6(OH)2) which provides the compressive strength of the bone. Sharpey’s Fibers are lateral fibrous elements extended into the bone matrix. Blood Vessels, Nerves, Lymphatic vessels (Haversian canals)Structure of a bone Bone tissue of which bones are composed of may be described as compact bone or trabecular bone. The compact bone forms the outer layer of the bone itself. It is ivory-like and dense in structure and has no cavities. It is the shell of many bones and surrounds the trabecular bone in the center. The trabecular bone may also be reffered to as the spongy or cancellous bone. It has numerous cavities and contains the bone marrow. Complete osteons are usually absent here due to the thinness of the trabeculae. It consists of three layers namely: circumferential lamella (subperiosteal bone), concentric lamella and the interstitial lamella. The circumferential lamella makes up the outside surface of the bones. It is not made up of small concentric circles and follows the surface of circumference of the bone. The next one is the concentric lamella which contains the basic unit of the bone called the osteon.
  • 5. The osteon contains the Haversian canals which provide a pathway so that nutrients from the bloodvessels may reach the osteocytes. The Volkmann’s canals interconnect the Haversian canals forming anetwork of blood vessels. The third one is the interstitial lamella which is said to be the incomplete orfragmented osteons that are located between the secondary osteons. They represent the remnantosteons left from partial resorption of old osteons during bone remodeling. circumferential lamella concentric lamellaGrowth of bone It is also known as ossification or the formation of the bone. It includes both bone formation andbone resorption or the removal of mineral materials and organic matrix of bone. There are three typesof ossification. These are the endochondral formation, intramembranous formation and the suturalbone growth. Endochondral formation is the formation of bone tissue that is preceded by the formation ofcartilage model that resembles the shape of the bone that is to be formed. The cartilage predecessor ofthe bone mineralizes and is gradually removed by resorption. The bone tissue formed replaces it. Theexamples of bones formed through this method are the long bones of the arms and legs. The second one is the intramembranous formation wherein the bone tissue is formed withoutpreceding cartilage pattern. It is formed by fibrous connective tissue. Osteoblasts secrete bone matrixcalled the osteoid and the matrix then mineralizes to form the bone proper. Some of the osteoblastsbecome trapped in the forming bone and become osteocytes. Examples of bones formed through thismethod are the mandible and maxilla. Lastly, the sutural bone growth. Sutures are fibrous joints between the bones which permit the skulland face to accommodate growing organs. It has the same osteogenic potential as the periosteum and itconnects 2 periosteal surfaces, namely: the cambium which is the osteogenic layer and the capsulewhich is the inner layer.Alveolar process As such develops in the conection with the growth of the jaw and erruption of the of teeth.These are parts of the maxilla and mandible that are especially designed to provide sockets and supportof teeth. It is called processus alveolaris in maxila and pars alveolaris in the mandible bone.
  • 6. Functions It supports the tooth roots on the facial and on the palatal/lingual sides. It is the one responsiblefor the separation of teeth from mesial to distal. And also contributes to absorption and distribution ofoclussal pressure produced in tooth to tooth contact.Structures of the alveolar boneCortical plate It provides strength and protection for the supporting bone (maxilla and mandible also acts as asite for attachment for skeletal muscles. It is covered by periosteum. In labial sections cortical plate isattached directly to the alveolar bone proper. This arrangement causes the bone overlying the roots ofthe anterior teeth brittle in nature. Cortical plate in mandible is more dense and has fewer perforationsfor passage of vessels and nerves than in the maxilla.Alveolar Crest The alveolar crest is the highest point of the alveolar ridge and joins the facial and lingualcortical plates.
  • 7. Trabecular Bone Trabecular or spongy bone lies within the central portion of the alveolar process, and is the lessdense, cancellous bone. When viewed by a radiograph, trabecular bone has a web-like appearance.Alveolar bone proper The alveolar bone proper is a thin layer of compact bone, which is a specialized continuation ofthe cortical plate and forms the tooth socket. The lamina dura is a horseshoe shape white line on adental radiograph that roughly corresponds to the alveolar bone proper.Development of the alveolar process The alveolar bone starts to develop near the end of the second month of fetal life. Both themaxilla and mandible form a groove at their free surface (towards the oral cavity). The tooth germs of
  • 8. the deciduous teeth are contained in this groove. Gradually, bony septa develop between the adjacenttooth germs. In fetal life, the developing bone is a non-lamellar type of bone surrounded by a thickperiosteum. Areas of secondary cartilages may appear at the growing alveolar margins during the rapidgrowth of alveolar bone. After eruption of teeth, the alveolar bone gradually takes its adult form. The alveolar processstarts developing strictly during tooth eruption. During the bell stage, the dental follicle migrates away from the tooth germ in preparation forthe formation of periodontium. Histodifferentiation happens. Fibers from outside of the dental folliclewill form a membrane containing network of fibers which contain cells. This develops into osteogenictissue where cells differentiate into osteoblasts. As the tooth erupts, the membranous bone in the body of mandible and maxilla extendsocclusally. It serves as an attachment of the periodontal ligament to hold the tooth in place.
  • 9. Reorganization of the spongiosa or the cancellous bone also determines the development of thealveolar process. In non-functional arches, the traberculae becomes thinner and therefore lessens thesize of the alveolar bone. in functional arches, the traberculae of the alveolar bone thickens to functionwell in mastication and therefore makes the alveolar process longer or larger.Vascular Supply of Alveolar Bone The alveolar processes of the maxilla are supplied with oxyhemoglobinated blood from theposterior superor alveolar artery, middle superior alveolar artery and anterior superior alveolar arterywhich are all branches of maxillary artery. The Alveolar processes of the mandible are supplied withoxyhemoglobinated blood by the inferior alveolar nerve which is also a branch of maxillary artery. Themaxillary artery is a branch of the external carotid artery.Age ChangesMesial drifting It is a gradual movement of all the posterior teeth in a mesial direction. It occurs only if therehas been interproximal wear between the teeth. The drift is not a passive one however, as it has beenshown that during chewing, the bite force has a mesial component. Bone will be resorbed in the tensearea of the periodontal ligament and bone formation in the pressured area.Masticatory Forces The alveolar bone will adapt and bone marrow spaces will become smaller and the trabeculabecomes thicker for increase in masticatory function.
  • 10. Loss of function As a result of loss of function, the bone marrow spaces become wider and the trabeculabecomes thinner.Tooth extraction/exfoliation Alveolar process disappears because of bone resorption by osteoclasts. There will be anapposition of embryonic bone. There will be a formation of residual or alveolar ridge. The residual ridgewill appear more radiolucent in radiographs because of its lesser calcification.The MandibleThe mandible is the largest and strongest bone of the face, serves for the reception of the lower teeth. Itconsists of a curved, horizontal portion, the body, and two perpendicular portions, the rami, which unitewith the ends of the body nearly at right angles.Development of the Mandible: The Body of the Mandible
  • 11. 1. The mandible is ossified in the fibrous membrane covering the outer surfaces of Meckels cartilages. These cartilages form the cartilaginous bar of the mandibular arch and are two in number, a right and a left.2. Their proximal or cranial ends are connected with the ear capsules, and their distal extremities are joined to one another at the symphysis by mesodermal tissue.3. Meckel’s cartilage has a close, relationship to the mandibular nerve, at the junction between posterior and middle thirds, where the mandibular nerve divides into the lingual and inferior dental nerve. The lingual nerve passes forward, on the medial side of the cartilage, while the inferior dental lies lateral to its upper margins & runs forward parallel to it and terminates by dividing into the mental and incisive branches. From the proximal end of each cartilage the malleus and incus, two of the bones of the middle ear, are developed; the next succeeding portion, as far as the lingula, is replaced by fibrous tissue, which persists to form the sphenomandibular ligament & the perichondrium of the cartilage persist as sphenomallular ligament.4. Between the lingula and the canine tooth the cartilage disappears, while the portion of it below and behind the incisor teeth becomes ossified and incorporated with this part of the mandible. The mandible first appears as a band of dense fibrocellular tissue which lies on the lateral side of the inferior dental and incisive nerves. For each half of the mandible,
  • 12. 5. Ossification takes place in the membrane covering the outer surface of Meckels cartilage and each half of the bone is formed from a single center which appears, in the region of the bifurcation of the mental and incisive branches, about the sixth week of fetal life.6. REMNANT’S OF MECKEL’S CARTILAGE a. Ossification grows medially below the incisive nerve and then spread upwards between this nerve and Meckel’s cartilage and so the incisive nerve is contained in a trough or a groove of bone formed by the lateral and medial plates which are united beneath the nerve. At the same stage the notch containing the incisive nerve extends ventrally around the mental nerve to form the mental foramen. Also the bony trough grow rapidly forwards towards the middle line where it comes into close relationship with the similar bone of the opposite side, but from which it is separated by connective tissue. b. A similar spread of ossification in the backward direction produces at first a trough of bone in which lies the inferior dental nerve and much later the mandibular canal is formed. The ossification stops at the site of future lingula. By these processes of growth the original primary center ossification produces the body of the mandible.
  • 13. Development of the Mandible: The Ramus of the Mandible 1. The ramus of the mandible develops by a rapid spread of ossification backwards into the mesenchyme of the first branchial arch diverging away from Meckel’s cartilage. This point of divergence is marked by the mandibular foramen. 2. Somewhat later, accessory nuclei of cartilage make their appearance: a. a wedge-shaped nucleus in the condyloid process and extending downward through the ramus. b. a small strip along the anterior border of the coronoid process. 3. The condylar cartilage: a. Carrot shaped cartilage appears in the region of the condyle and occupies most of the developing ramus. It is rapidly converted to bone by endochondral ossification (14th. WIU) it gives rise to: b. Condyle head and neck of the mandible. c. The posterior half of the ramus to the level of inferior dental foramen 4. The coronoid cartilage: a. It is relatively transient growth cartilage center ( 4th. - 6th. MIU). it gives rise to: i. Coronoid process. ii. The anterior half of the ramus to the level of inferior dental foramen 5. These accessory nuclei possess no separate ossific centers, but are invaded by the surrounding membrane bone and undergo absorption.The Maxilla The maxillæ are the largest bones of the face, excepting the mandible, and form, by their union,the whole of the upper jaw. Each assists in forming the boundaries of three cavities, the roof of themouth, the floor and lateral wall of the nose and the floor of the orbit; it also enters into the formationof two fossæ, the infratemporal and pterygopalatine, and two fissures, the inferior orbital andpterygomaxillary. Each bone consists of a body and four processes—zygomatic, frontal, alveolar, andpalatine.Development of the Maxilla: The Maxilla Proper 1. It develops in the mesenchyme of the maxillary process of the mandibular arch as intramembranous ossification. It has one center of ossification which appears in a band of fibrocellular tissue immediately lateral to and slightly below the infra orbital where it gives off its anterior superior dental branch. The ossification center lies above that part of the dental lamina from which develop the enamel organ of the canine.
  • 14. 2. The ossified tissue appears as a thin strip of bone. It spread in different directions as: a. Backward: Below the orbit toward the developing zygomatic bone. b. Forward: Toward the future incisor region c. Upward: To form the frontal process of the maxilla.3. As a result of this pattren of bone deposition, a bony trough is formed (infraorbital groove) where the infraorbital nerves lies. The inner and outer edges of this groove grow up, meet and fuse forming a canal that encloses the nerve & open anteriorly at the infraorbital foramen4. The ossified tissue appears as a thin strip of bone. It spread in different directions as: a. downward: To form the outer alveolar plate for the maxillary tooth germs b. Toward the midline: Ossification spreads with the development of the palatal process in the substance of the united palatal folds to form the hard palate. At the union between the palatal process and the main part of the developing maxilla, a large mass of bone produced. From this region & on the inner side of the dental lamina & tooth germs, the inner alveolar plate of deciduous canines and molars develops.5. Development of the maxillary sinus: At 4 MIU as a small depression of the mucosa of the lateral wall of the nasal cavity. In its gradual extension the sinus comes into relation with the maxilla above the level of the palatal process & hallows out the interior of the bone, so separating its upper or orbital surface from its lower or dental region.
  • 15. Development of the Maxilla: The PremaxillaTwo centers of ossification for the premaxilla: A. The palato-ficial center: Appear at the end of 6 WIU. It starts close to the external surface of the nasal capsule, in front of the anterior superior dental nerve and above the germ of the lateral deciduous incisor. From this center bone formation spreads: 1. Above the teeth germ of the incisors. 2. Then downward behind them. To form the inner wall of their alveoli & palatal part of the premaxilla. B. The prevomerine center (paraseptal center): It begins at about 8-9 WIU along the outer alveolar wall. It is situated beneath the anterior part of the vomer bone and it forms that part of the bone lies mesial to the nasal paraseptal cartilage.Accessory Cartilages 1. Accessory cartilagenous center appears in the region of the future zygomatic or molar process and this undergoes rapid ossification & adds considerable thickness to the bulk of this part. 2. Also small areas of secondary cartilagenous center appears along the growing margin of the alveolar plate. 3. In the middle line of the developing hard palate between the two palatine processes.
  • 16. Lines in Bones There are four lines that can be seen in bone tissues: reversal, cementing, aplastic and resting lines. Reversal line shows the evidence of previous remodeling activity and it is formed by filling of new bone in a previously resorbed cavity. The relative amount of reversal lines indicates the amount of remodeling that has occurred. Cementing lines separates adjacent lamellae of bone from each other. It is also refered RL as the incremental lines in bone . Aplastic line is a layer of basophilic AL substance which laid down on the surface of the bone that has been AL inactive for a long period of time. While resting line is a line which separates the new layer of bone from the old bone which has been inactive. CL ALClinical Consideration Although bone is one of the hardest tissues in the human body, bone is also is biologically a highly plastic tissue. It is also exceedingly sensitive to pressure. Bone resorbs on the side of pressure and apposes on the side of tension. On sites where bone receives pressure, high amounts of cyclic adenosine monophosphate can also be observed. Bone also gives response to its functionality. A highly functional bone is denser than a bone that does not receive any functional forces at all. When bones are fractured or a tooth was extracted from it, embryonic type of bone or coarse fibrillar bone is formed on the site. Bone is continuously remodels and is being replaced by a newer bone tissue from embryonic period until death is termed as bone turnover. Bone turnover rate of 30% to 100% per year is common to rapidly growing children. In adults, it is decreased to 5% per year. Periodontal diseases gives the most frequent and harmful change in the alveolar process. Progressive loss of alveolar bone in periodontal disease is difficult to control and even more difficult to regenerate or repair when damaged. This situation is one of the greatest challenges to periodontics. Studies and experiments on implanting artificial roots on the alveolar bone gave promising results in decreasing the speed of bone resorption. Acromegaly is an overgrowth of the jaw bone. Acromegaly Periodontitis
  • 17. BIBLIOGRAPHYOral Histology – Development, Structure and Function, 4th Edition by Ten Cate, A. R.Orban’s Oral Histology and Embryology, 11th Edition by Bhaskar, S. N.Permar’s Oral Histology and Microscopic Anatomy, 10th Edition by Melfy, R. C.Northern Illinois University:Department of Biological Sciences WebsiteMedscap WebsiteOral Biology by Berkovitz, Moxham, Linden, and Sloan