DEFINITIONCancer of the larynx is a malignant tumor in the larynx(voice box).
INCIDENT RATEIt accounts for 2% to 3% of all malignancies.Four times more in men than women.Most common in age above 60.Each year approximately 9000 new cases are detecting.3700 persons with cancer of larynx will dies.90% of untreated people will die with in 3years.Potentially curable if diagnosed and treated early.
ETIOLOGY AND RISK FACTORSCARCINOGENS Tobacco Combined effects of tobacco and alcohol Asbestos Second hand smoke Paint fumes Cement dust Chemicals Tar products Leather and metals
Contn..OTHER FACTORS Straining the voice Chronic laryngitis Nutritional deficiencies Familial predisposition Age Gender Race (more prevalent in African American) Weakened immune system
DIAGNOSTIC EVALUATION History collection Physical examination laryngoscopy Endoscopy biopsy CT scan and MRI Barium swallow
MEDICAL MANAGEMENT Chemotherapy:Drugs are used to prevent the multiplication of tumorcells, either by killing or by preventing cell divisionSystemic chemotherapyRegional chemotherapy Chemoprevention Drug Isotretinoin used to prevent the recurrence.
Contn…. Radiosensiteizers: drugs that make tumor cells moresensitive to radiation therapywhen used in combination with chemotherapy, itis more effective.
SURGICAL MANAGEMENT Cordectomy Supraglottic laryngectomy Hemilaryngectomy Partial laryngectomy Total laryngectomy Thyroidectomy Laser surgery Adjuvent therapy