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What is Hereditary
Fructose Intolerance?
Fructose intolerance is a
recessive genetic disease
in which the patients lack
the gene which code for
an enzyme called aldolase
B in the liver which is
responsible for digestion
of fructose and sucrose.
• Fructose is a 6C
  compound
• It is a ketose
• It has a keto functional
   group in the
   Second carbon atom.
Nausea and vomiting if fructose or sucrose is consumed in any form.

Mild jaundice which can be observed as yellowish discoloration on the skin and sclera

Hypoglycemia if fructose is consumed

  Dental caries is not seen in these patients.
Palpation           Eye examination              Liver biopsy

  By palpation we
                    By examining the      Biopsy can indicate the
  can identify
                    eye we can identify   Abnormal level of enzyme
  hepatomegaly
                    the presence of       Especially lack of aldolase B
  and
                    jaundice which is
  spleenomegaly
                    another symptom
  which are the
                    of HFI.
  symptoms of
  HFI.
Streptococcus mutans
                       Grown on selective agar
After gram staining    medium like Lauria media
found to be gram       (fructose and sucrose
positive               rich).
Fructose free diet is the best treatment for
avoiding complications like liver failure and death

It is unusually seen in children that they restrict
themselves from consuming sweets and chocolates
who suffer from this disorder.
* HFI
* Dental caries

* Microbiological basis of Dental

* Relation between HFI and Dental caries
Ida

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Ida

  • 1.
  • 3. Fructose intolerance is a recessive genetic disease in which the patients lack the gene which code for an enzyme called aldolase B in the liver which is responsible for digestion of fructose and sucrose.
  • 4. • Fructose is a 6C compound • It is a ketose • It has a keto functional group in the Second carbon atom.
  • 5.
  • 6.
  • 7. Nausea and vomiting if fructose or sucrose is consumed in any form. Mild jaundice which can be observed as yellowish discoloration on the skin and sclera Hypoglycemia if fructose is consumed Dental caries is not seen in these patients.
  • 8. Palpation Eye examination Liver biopsy By palpation we By examining the Biopsy can indicate the can identify eye we can identify Abnormal level of enzyme hepatomegaly the presence of Especially lack of aldolase B and jaundice which is spleenomegaly another symptom which are the of HFI. symptoms of HFI.
  • 9.
  • 10.
  • 11.
  • 12. Streptococcus mutans Grown on selective agar After gram staining medium like Lauria media found to be gram (fructose and sucrose positive rich).
  • 13.
  • 14. Fructose free diet is the best treatment for avoiding complications like liver failure and death It is unusually seen in children that they restrict themselves from consuming sweets and chocolates who suffer from this disorder.
  • 15. * HFI * Dental caries * Microbiological basis of Dental * Relation between HFI and Dental caries