Sectors Of The National And Global Economy Including TextilesPresentation Transcript
Medical Applications of Nanotechnology Timothy E. Morey, M.D. Associate Professor of Anesthesiology University of Florida
How small is nano? E. Corcoran. The Next Small Thing. Forbes Magazine , 07/23/01 Decade: 1/3 rd second Acre: 1/100 th square inch $151,700: 1/100 th cent Scale: Nanoscale
Nanotechnology Growth S. Milunovich, J. Roy. United States Technology Strategy. Merrill Lynch. 4 Sept. 2001
Smart Nanostructures for Selective Drug Delivery
Drug Delivery for:
#1 - Cardiovascular disease
#2 – Cancer
#3 - Infectious diseases
Toxin Removal for:
Adverse drug reactions >106,000 deaths/yr
Pesticide Poisonings >220,000 deaths/yr
Video Clip Scale: 1/40 th of red blood cell Nanotube Nanocap
- drug overdose
- brain trauma
- disease markers
- law enforcement
- homeland security
Why the University of Florida?
Comprehensive university on a compact campus
Institutional support and priority (2002)
“… biotechnology, particularly at the interface of medicine and nanoscience.”
Interdisciplinary faculty with critical mass and focus
Active OTL partner with a biotechnology incubator
NanoMedical Research Center
Vision: Create and harness nano-structured material technologies for the prevention, detection and treatment of diseases in order to enhance the public health and to expand the Florida and national economies
Focus: Develop nanostructures for medical diagnostics and therapeutics
Funding: State of Florida Centers of Excellence
$19.9 million for FY2003-07 with milestones
Product: Knowledge / Publications / Translational Science Prototypes and IP for OTL licensure
Additional Slides to Answer Questions
MIT Institute for Soldier Nanotechnologies
Vision: lighter, faster, more agile force using nanotech.
Focus: use nanotechnology to dramatically improve the survival and lethality of soldiers
Faculty: 40 faculty in eight academic departments >100 students and postdocs 11 supportive staff members
Funding: United States Army
5 year, $50 million grant beginning FY2002
Product: create a battlesuit that combines high-tech capabilities with light weight and comfort
What is nanotechnology
Creation of functional materials, devices, and systems.
Control of matter on the nanometer (1-100 nm) length scale.
Exploitation of novel properties and phenomena developed at that scale.
What is nano? nanos: dwarf nano 10 -9 mikros: small micro 10 -6 milli: thousand milli 10 -3 chilioi: thousand kilo 10 3 megas: large mega 10 6 gigas: giant giga 10 9 teras: monster tera 10 12 Origins Prefix Power
Why is the nanometer scale different?
The wavelike properties of electrons inside matter are influenced by variations on the nanometer scale.
The systematic organization of matter on the nanometer length scale is a key feature of biological systems.
Nanoscale components have very high surface areas.
The finite size of material entities, determine an increase of the relative importance of surface tension and local electromagnetic effects.
The interaction wavelength scales of various external wave phenomena become comparable to the material entity size.
"There's plenty of room at the bottom."
Richard P. Feynman, Ph.D.
stain resistant textiles
information recording layers
high hardness cutting tools
chemical and bio-detectors
advanced drug delivery systems
Who else is interested?
Rensselaer Polytechnic Institute (Troy, NY)
focus on physical nanotechnology
Rice University (Houston, TX)
focus on environment and carbon nanotubes
Cornell University (Ithaca, NY)
origins in materials engineering
University of Michigan (Ann Arbor, MI)
invested in therapeutics
Why Nano-Medical in Florida?
Targets key industries in Florida
3 of the 10 highest wage Florida industries
3 times as many jobs exist in these industries as in Florida’s IT industries
Florida – Profile of the State Economy; M. Porter; Harvard Business School; Prepared for Gov Bush; 2002
State of Florida Center of Excellence
State of Florida
$30 million for 2-5 Centers of Excellence
Grants solicited in 2002 for FY2003 commencement
NanoMedical Research Center
Focused on nanomedical therapeutics and diagnostics
Collaboration of chemists, engineers, medical researchers
Requested $20 million
Ranked 3 rd of 16 applicant centers
Awards: UCF, UF (regenerative medicine), FAU
UF Strategic Plan: Priority Areas
Cancer and Genetics
Research on the Brain
Biotechnology – Interface of Medical Science and Nanoscience
Children and Families
UF Unique Capabilities - Programs
Deliverables Pipeline Pesticide detoxification Drug detox Bacteriorhodopsin-based data storage Microemulsion formulation technology Biophotonics-based detection of disease Nanoengineered pulmonary drug delivery systems Knowledge of bio-nano toxicity Nanosensors for management of traumatic brain injury Smart nanostructures for targeted drug delivery 2003 2005 2009 2004 2006 2007 2008 Breath detection of drugs Breath detection of diseases Flexible device/system integration Deliverables Chip-based drug delivery system