Folding - Molecular Biology

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Folding - Molecular Biology

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Folding - Molecular Biology

  1. 1. Texto adicional Texto adicional Texto adicional texto adicional Texto adicional texto adicional New RNA Repair Technology and Therapeutic Strategies for Controlling Gene Expression Anny Carolina Sarria Mena Medicine Student, 3rd semester Teacher: Lina María Martinez Sánchez Molecular Biology UPB - 2012
  2. 4. INTRODUCTION The proper use of the tools offered by molecular biology would be of great benefit to modern medicine, as with so many technological advances, to the heart of mutations and would reduce the pathologies that they can be repaired. Interestingly travésde as identifyingRNA sequences and errors in the maturation of the same drugs can create and repair mechanisms such as RNA.
  3. 5. Scientists Create Novel RNA Repair Technology    
  4. 6. Scientists Create Novel RNA Repair Technology <ul><li>Identification a compound that can help repair a specific type of defect in RNA, a type of genetic material. </li></ul><ul><li>Methods in the new study could accelerate the development of therapeutics to treat a variety of incurable diseases such as Huntington's disease, Spinocerebellar ataxia, and Kennedy disease. </li></ul>
  5. 7. Scientists Create Novel RNA Repair Technology <ul><li>Describe a method to find compounds that target defective RNAs, specifically RNA that carries a structural motif known as an &quot;expanded triplet repeat. </li></ul><ul><li>The triplet repeat, a series of three nucleotides repeated many more times than normal in the genetic code of affected individuals, has been associated with a variety of neurological and neuromuscular disorders. </li></ul>
  6. 8. <ul><li>It has been shown recently that both the protein and the RNA are toxic. The toxic RNA defect actually sucks up other proteins that play critical roles in RNA processing, and that is what contributes to these various diseases. </li></ul><ul><li>Also opens up new avenues for therapeutic development because we have clearly demonstrated that small molecules can reverse this type of defect. </li></ul>Scientists Create Novel RNA Repair Technology
  7. 9. COMMENT
  8. 10. New RNA-Based Therapeutic Strategies for Controlling Gene Expression  
  9. 11. New RNA-Based Therapeutic Strategies for Controlling Gene Expression <ul><li>Small RNA-based nucleic acid drugs represent a promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes. </li></ul><ul><li>Short strands of nucleic acids, called small RNAs, can be used for targeted gene silencing, making them attractive drug candidates. </li></ul>
  10. 12. New RNA-Based Therapeutic Strategies for Controlling Gene Expression   <ul><li>Researchers have discovered new mechanisms by which RNA drugs can control gene activity. A comprehensive review article in Nucleic Acid Therapeutics, a peer-reviewed journal published by Mary Ann Liebert, Inc., details these advances . </li></ul>
  11. 13. New RNA-Based Therapeutic Strategies for Controlling Gene Expression <ul><li>Review common features shared by RNAi pathways for controlling gene expression and focus in detail on the potential for Argonaute-RNA complexes in gene regulation and other exciting new options for targeting emerging forms of non-coding RNAs and pre-mRNAs in the article &quot;Argonaute and the Nuclear RNAs: New Pathways for RNA Mediated Control of Gene Expression.&quot; </li></ul>
  12. 14. COMMENT
  13. 15. Medical Utility
  14. 16. Medical Utility The RNA may represent one of the great advances in medicine, if used properly and that the viruses that plague humanity are involved in transcription and maturation of the same. And with the proper identification of the processing and maturation of these viruses can find a solution by using drugs that can attack in its genome .
  15. 17. Medical Utility If accurately elucidate the general maturation and processing of RNA from this may create drugs that can &quot;manipulate&quot; the RNA and fix all the mutations that can occur.
  16. 18. Medical Utility Through the years and with the expertise of researchers have made ​​significant progress in the field of medicine have been established treatments and therapies, drugs and instruments which act on the genome and polymorphisms reduce all thanks to Molecular Biology.
  17. 19. BIBLIOGRAPHY <ul><li>“ Scientists Create Novel RNA Repair Technology”, Science Daily Journal, internet edition, January 2012, http://www.sciencedaily.com/releases/2012/01/120117191544.htm </li></ul><ul><li>“ New RNA-Based Therapeutic Strategies for Controlling Gene Expression”, Science Daily Journal, internet edition, February 2012, http://www.sciencedaily.com/releases/2012/02/120202164825.htm </li></ul>

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