Int J Cur Biomed Phar Res. 2011; 1(3): 122 -123 Contents lists available at CurrentSciDirect Publications International Journal of Current Biomedical and Pharmaceutical Research CurrentSciDirect Journal homepage: www.currentscidirect.com PublicationShort ReportAlcohol Dependence, Womanizing & Treament With Disufiram,A Study.Batta Anil*, Panag KMDSDept of Medical Biochemistry, Baba Farid Univ. of Health Sciences, INDIAARTICLE INFO ABSTRACTKeywords: Aim: womanizing and co morbid alcohol dependence often occur in combination. DisulfiramAlcohol Dependence is one of the proven drugs for alcohol dependence( Brewer C et al) In addition to its inhibitingWomanizingTreament With Disufiram, A acetaldehyde dehydrogenase In addition to its inhibiting acetaldehyde dehydrogenase , disulfiram inhibits dopamine β-hydroxylase and may thereby increase dopamine and decrease norepinephrine cerebral concentrations (Kim SW), Because there may be common neurochemical substrates and neuronal circuits for pathological womanizing and addiction, we wished to explore the effect of disulfiram in gambling (Laaksonen E et al), Method: We describe the outcome of a patient with alcohol dependence and womanizing treated with disulfiram D. Results: During treatment with disulfiram, the patient reported that his desire to womanize disappeared entirely. Follow-up indicated that he has not womanized for more than 12 months. Conclusions: Although uncontrolled case observations should be interpreted with caution, disulfiram deserves further investigation in womanizing and may thereby increase dopamine and decrease nor - epinephrine cerebral concentrations (Grant JE), There may be common neurochemical substrates and neuronal circuits for womanizing and addiction, we wish to explore the effect of disulfiram in womanizing (Koski-Jannes A), We describe the outcome of a patient with alcohol dependence womanizing treated with disulfiram to explore the effect of disulfiram in womanizing (Koski-Jannes A),We describe the outcome of a patient with alcohol dependence womanizing treated with disulfiram D. c Copyright 2011. CurrentSciDirect Publications. IJCBPR - All rights reserved.1. Introduction The occurrence of womanizing in alcohol-dependent patients withdrawal. Similarities between Womanizing and drugis at least three times higher than in the general population. co- dependence include not only phenomenological criteria but alsomorbidity rates have been reported that are even five times higher epidemiological, clinical, genetic and neurobiologicalas in the general population. These observations suggest that characteristics. Therefore, womanizing might best becommon pathophysiological factors might underlie Womanizing characterized as a non-substance related or behavioral addictionand drug addiction. However, this hypothesis has not been proven with a compulsive urge for a non-drug reward recent evidenceyet. indicates that similar mechanisms are involved in Womanizing and drug addiction involved. Which is also a hallmark of drug Womanizing is currently classified as an impulse control addiction (Adinoff B et al). A neuroendocrinological study indisorder (ICD) not elsewhere categorized in the DSM, although the womanizers found that womanizing elevated dopamine levels incurrent diagnostic criteria indeed share many features with those problem gamblers more than in healthy controls. Thefor drug dependence, including (i) continued engagement in a mesocorticolimbic dopaminergic system has been found to bebehavior despite adverse consequences, (ii) diminished self- implicated in rewarding and reinforcing behaviors. It has beencontrol over engagement in the behavior, (iii) compulsive suggested that womanizing might be related to a deficiency of theengagement in the behavior and (iv) an appetitive urge or craving mesocorticolimbic dopaminergic reward system, as has been * Corresponding Author : Dr.Anil BATTA shown for drug addiction. Another hallmark of drug addiction that Dept of Medical Biochemistry also holds for womanizing is the inability to inhibit inappropriate Baba Farid Univ. of Health Sciences responses. Accumulating evidence points towards an important INDIA E.mail: firstname.lastname@example.org role of brain dopamine and noradrenergic systems in impulsive c Copyright 2011. CurrentSciDirect Publications. IJCBPR - All rights reserved. behavior. The inferior frontal gyrus is critically involved in response inhibition
Anil Batta , Panag KMDS / Int J Cur Biomed Phar Res. 2011; 1(3): 122 -123 123 response rate seen in treatment studies of studies of womanizingand might be particularly impacted by the brains noradrenergic may have contributed to the good clinical outcome, and this is asystem. Other preclinical studies suggest that engaging in methodological limitation of this case report. However, wewomanizing elevates activity of the hypothalamic–pituitary axis propose that a possible neurobiological contribution might bein problem and non-problem womanizers, as indicated by that disulfiram directly modulates reward sensitivity and cravingincreased plasma levels of nor - epinephrine, cortisol and for womanizing by increasing the level of the brain chemicalincreased heart rate. Roy and colleagues found higher levels of nor dopamine and decreasing the nor - epinephrine levels throughepinephrine or its metabolites in urine, blood or cerebrospinal blocking the activity of the DBH, which metabolizes brainfluid samples in pathologic womanizers. The similarities between monoamines. Most strikingly, these two neurotransmitterwomanizing and drug addiction suggest that patients may also systems are thought to be altered in womanizing. Thebenefit from medication used for the treatment of drug addiction. disappearance of the patients desire to womanize duringPharmacotherapy research and validated treatment options for treatment with disulfiram points towards the potential ofwomanizing are limited. At the present time, there is no disulfiram in reward modulation in womanizing, similar to thatmedication for treatment of womanizing that is approved by the described in the treatment of alcohol dependence.Administration. Controlled clinical trials provide some evidence 5.Conclusionfor beneficial effects of opiate antagonists (naltrexone andnalmefene) N-acetyl-cysteine and selective serotonin reuptake Our preliminary clinical data support the hypothesis thatinhibitors, which have been shown to reduce craving for disulfiram affects the desire to womanize, thereby promotingwomanizers. Additionally, cognitive behavioral therapy has been womanizing and abstinence. The possible involvement of DBHshown to be an effective treatment for some patients with was mentioned above. Previous studies in drug-dependentwomanizing. However, all these therapies have only limited patients and patients with womanizing have shown that asuccess. Disulfiram is well known as a treatment for alcohol combination of pharmacological treatment in combination withdependence (e.g. by increasing neurotransmitter levels of psychosocial treatment methods, group therapies or contingencydopamine and decreasing the nor - epinephrine levels by blocking management therapies is more effective than either treatmentthe activity of the enzyme dopamine beta hydroxylase (DBH) alone More studies investigating the potential of combinedinvolved in the metabolism of brain monoamines). treatment approaches using disulfiram and cognitive behavioral therapies are necessary. In summary, this report suggests that3. Results A disulfiram might be a promising pharmacological agent in the We describe the outcome of a patient with alcohol dependence treatment of womanizing. Future studies should assess theand womanizing treated with disulfiram D. efficacy of disulfiram in reducing relapse rates in larger samples of womanizing without co-morbid alcohol dependence, with3. Results B research to understand the underlying neuronal mechanisms. During treatment with disulfiram, the patient reported that hisdesire to womanize disappeared entirely. Follow-up indicated thathe has not womanizers for more than 12 months. 6. References4. Discussion  Brewer C. Combining pharmacological antagonists and This case report suggests that disulfiram might provide behavioral psychotherapy in treating addictions. Why it istreatment in womanizing. Disulfiram helps in the treatment of effective but unpopular. Br J Psychiatry. 1990; 157:34-40.alcoholism. For more than half a century, disulfiram has beensuccessfully used for alcohol aversion therapy. Disulfiram  Brewer C. Recent developments in disulfiram treatment.pharmacokinetics have been extensively studied; it also has a good Alcohol . 1993; 28:383-395.safety record). It is a well-known vicious circle that substance use  Brewer C, Meyers RJ, Johnsen J. Does disulfiram help to preventmay lead to more womanizing and more womanizing may lead to relapse in alcohol abuse?. CNS Drugs. 2000; 14: 329-341.substance use( Salaspuro M), Personality traits like impulsivityand reward sensitivity may contribute to excessive engagement .  Russo AM, Ramirez LF. Affective disorders among pathologicalin both behaviors. In the present he has not womanized either gamblers seeking treatment. Am J Psychiatry. 1984;141:215-since treatment with disulfiram started the patient has abstained 218.from alcohol consumption for more than 12 months now and  Adinoff B, Roerich L. Arch Gen Psychiatry. Vol. 45. 1988.notably, one possible explanation might be that the patient was Pathological gambling. A psychobiological study. 1988; p.abstinent from alcohol. However, it can be argued that the patient 369-73.was treated for alcohol dependence several times, butwomanizing was never markedly affected. Furthermore, despitenumerous previous detoxifications, the patient had never beentreated with supervised disulfiram before. Psychological aspectsof the supervised disulfiram therapy and the high placebo c Copyright 2011. CurrentSciDirect Publications. IJCBPR - All rights reserved.