Vera Zdravkovic -End users and Open access in biomedical science

Vera Zdravkovic -End users and Open access in biomedical science - Presentation Transcript

KORISNIK I OTVORENI PRISTUP Vera Zdravkovi ć

KORISNIK

Ko su korisnici ?

Lekari

I straživači

P redavači

Pacijenti/roditelji

Otvoreni pristup je posebno neophodan u zemlji kao Srbija

ČASOPISI SA SLOBODNIM PRISTUPOM

Medicina 314

Pedijatrija 43

Clinical Pediatric endocrinolgy (Japan)

International Journal of Pediatric endocrinology (US)

International Journal of Pediatrics (US)

POTREBA ZA INFORMACIJOM

U toku dežurstva dobijate poziv za konsultaciju

Mlado muško odojče primljeno zbog izmenjenog stanje svesti

Laboratorijske analize: nizak Na i visok K

Treba da isključite adrenalnu insuficijenciju

Ne postoje svi elementi kliničke slike

Konsult u jete Pubmed

International Journal of Pediatric Endocrinology Volume 2009 (2009), Article ID 195728, 4 pages doi:10.1155/2009/195728 Case Report Transient Pseudohypoaldosteronism due to Urinary Tract Infection in Infancy: A Report of 4 Cases Radha Nandagopal , 1 Priya Vaidyanathan , 2 and Paul Kaplowitz 2 1 Inter-Institute Pediatric Endocrinology Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 2 Department of Endocrinology, Children's National Medical Center, Washington, DC 20010, USA Received 5 December 2008; Revised 10 March 2009; Accepted 23 April 2009 Academic Editor: Christa Flueck Copyright © 2009 Radha Nandagopal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract Hyponatremia with hyperkalemia in infancy is an uncommon but life-threatening occurrence. In the first weeks of life, this scenario is often associated with aldosterone deficiency due to salt-wasting congenital adrenal hyperplasia . However, alternative diagnoses involving inadequate mineralocorticoid secretion or action must be considered, particularly for infants one month of age or older. We report four infants who presented with profound hyponatremia accompanied by urinary tract infection , ultimately leading to the diagnosis of transient pseudohypoaldosteronism. Our cases provide support for the idea that the renal tubular resistance to aldosterone is due to urinary tract infection itself rather than to underlying urinary tract anomalies typically found in these infants. Awareness of this condition is important so that serum aldosterone, urine sodium, and urine cultures may be obtained immediately in any infant presenting with hyponatremia and hyperkalemia in whom a diagnosis of congenital adrenal hyperplasia was not found. Adequate replacement with intravenous saline and antibiotic therapy is sufficient to correct sodium levels over 24–48 hours.

JOŠ JEDNA PRIMENA OA

Saopštavanje važnih informacija javnosti

Neželjena dejstva leka

I nicijalno lečenje hipertireoize - lekovi

Propiltiouracil i metimazolski preparati

Poslednjih godina je prijavljeno 1 4 slučajeva insuficijencije jetre kod dece usled primene PTU

U registru pacijenata kojima je iz ovog razloga transplantirana jetra postoji 8 dece

ZAKLJUČAK WORKSHOPA ODRŽANOG 2008

Considering the above, we believe that PTU should never be used as first line treatment in children. PTU use should only be considered in rare circumstances, such as preparation for surgery in a patient allergic to MMI or in pregnancy.

PUBLIKACIJA ZAKLJUČAKA

Kako alarmirati javnost

S. Rivkees koji ima 140 radova na Pubmedu, u časopisima koji imaju IF i 50 se odlučuje za OA časopis

International Journal of Pediatric Endocrinology Volume 2009 (2009), Article ID 132041, 8 pages doi:10.1155/2009/132041 Commentary Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use Scott A. Rivkees 1 and Donald R. Mattison 2 1 Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, CT 06520, USA 2 Obstetric and Pediatric Pharmacology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA Received 5 April 2009; Accepted 7 April 2009 Izveštaj workshop -a koji je održan pod pokroviteljstvom Best Pharmaceuticals for Children Act, oktobra 2008 da bi se procenila bezbednost primene PTU kod dece

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