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Professors Wall and Tonellato of Harvard Medical School in collaboration with Beth Israel Deaconess Medical Center discuss the emerging area of clinical whole genome sequencing analysis and tools. They report on the use of Amazon EC2 and Spot Instances to achieve a robust clinical time processing solution and examine the barriers to and resolution of producing clinical-grade whole genome results in the cloud. They benchmark an AWS solution, called COSMOS, against local computing solutions and demonstrate the time and capacity gains conferred through the use of AWS.
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