On October 23rd, 2014, we updated our
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There is no singular test for diagnosing rheumatoid
Instead, rheumatoid arthritis is diagnosed based
on :history & physical examination & investigations
The Importance of Early Diagnosis
RA is progressive, not benign.
Structural damage/disability occurs
within first 2 to 3 years of disease.
Slower progression of disease linked
to early treatment
6 weeks of morning stiffness > 1 hr .
6 weeks of swelling of three or more joints .
6 weeks of swelling of wrist, MCP, PIP.
Symmetrical joint swelling.
X-ray changes that must include erosions or
unequivocal bony decalcification.
6. Rheumatoid nodules.
7. Positive serum rheumatoid factor.
Can do usual
or limited mobility
of 1-3 joints.
• Are made after a full medical and family history
and physical and diagnostic testing.
• Medical testing may include a wide variety of tests
ANA (Anti nuclear antibodies)
MRI (Magnetic resonance imaging) & US (ultra sound)
Anti cyclic citrullinated peptide (CCP):
has been found to be more specific than
rheumatoid factor in rheumatoid arthritis
And high titer anti-CCP may predict aggressive
Antinuclear antibody: positive in systemic
lupus erythematosus (SLE) and related
conditions; also in up to 30% of rheumatoid
arthritis patients and weakly positive in up to
10% of the normal population.
• C-Reactive protein
– Correlates with disease activity and radiologic
– One of the most responsive acute phase reactants
– Can be elevated in many non-RA related
• Erythrocyte sedimentation rate
– Influenced by non-acute phase response factors
– Can be elevated in many non-RA related
Is an autoantibody that is present in the blood
of most people with RA (75-80%)
Directed against host immunoglobulin
(is positive in no more than 5 percent of patients
without rheumatoid arthritis).
6-12 months following disease onset if
Liver function tests… mild elevation of alkaline
phosphatase and .Low serum albumin .
CBC…normochromic normocytic or Microcytic anemia .
Hemoglobin slightly decreased; hemoglobin averages
around 10 g/dL .Platelets & WBCs Usually increased.
Urinalysis … Microscopic hematuria or proteinuria
may be present, indicat connective tissue diseases.
Joint fluid … to rule out other diseases; 5,000 to
25,000 WBC with polymorphonuclear leukocytes .
cultures are negative, there are no crystals, and fluid
glucose level typically is low.
X-Ray of both hands and wrists and feet for
MRI it is more sensitive to detect RA change.
Loss of joint space
Soft tissue swelling
• Social factors
– Low socioeconomic status
– Less education
– Psychosocial stress
– female sex
• Physical factors
– Extra-articular manifestations
– Elevated CRP and ESR
– High titers of RF
– early Erosions on x-ray
– Duration of disease
Goals of Treatment
Slow down or stop joint damage
Maintaining the ability to function in daily
activities, improving the quality of life.
• Current Treatment
• Non - pharmacological
• Routine monitoring and ongoing care.
• Physiotherapy is a vital part of treating RA may be
useful in decreasing the symptoms of RA.
• program of exercise strengthens joints & minimize
deformity and increase the range of movement and
• Natural treatments include using massage with
herbs, magneto therapy etc..
• Occupational therapy can give advice to do every
day activities with less pain or advice on how to use
splints, skills training.
• Weight loss & Smoking cessation
used only for pain relief
•used as an adjunct along with DMARD’s to reduce the
inflammation and pain
reduction in swelling.
mobility, flexibility, range of motion
Ineffective in Erosive disease
NSAID’S act by inhibiting COX-1 &2 & thus reduces
- GI toxicity – ulcer
•DMARD,s (disease modifying anti-rheumatic
• used to slow down the progression of disease.
E.g. Methotrexate once weekly Oral or IM
Advantages of DMARDs
•Slow disease progression
•Improve functional disability
•Interfere with inflammatory processes
•Retard development of joint erosions
Active Hepatitis B Infection
Multiple sclerosis, optic neuritis
Active serious infections
Chronic or recurrent infections
History of TB or positive PPD (untreated)
Congestive heart failure (Class III or IV)
Early appropriately aggressive intervention
in patients with inflammatory arthritis:
critical to best possible outcome.
The combination of a biologic plus MTX is
frequently more effective than either agent
• Early and aggressive disease control
– Rheumatologist Referral
• Early/Undiagnosed: NSAIDs, short course
• Late/Uncontrolled: DMARD therapy
– depends on the presence or absence of joint
damage, functional limitation, presence of
predictive factors for poorer prognosis
• Establish early diagnosis of RA
• Document baseline disease activity and
• Estimate prognosis of patient
• Patient education
• Physical/occupational therapy
• Consider NSAID and/or local or low-dose steroids
• Start disease-modifying agent within 3 months
Periodically assess disease