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Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
Acute Generalized Exanthematous Pustulosis
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Acute Generalized Exanthematous Pustulosis

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Acute Generalized Exanthematous Pustulosis …

Acute Generalized Exanthematous Pustulosis

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  • 1. ACUTEACUTEACUTEACUTEACUTEACUTEACUTEACUTE GENERALIZEDGENERALIZEDGENERALIZEDGENERALIZEDGENERALIZEDGENERALIZEDGENERALIZEDGENERALIZED EXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUSEXANTHEMATHOUS PUSTULOSISPUSTULOSISPUSTULOSISPUSTULOSISPUSTULOSISPUSTULOSISPUSTULOSISPUSTULOSIS CHULEEPORN KONGMEESOOK, M.D.CHULEEPORN KONGMEESOOK, M.D.CHULEEPORN KONGMEESOOK, M.D.CHULEEPORN KONGMEESOOK, M.D.CHULEEPORN KONGMEESOOK, M.D.CHULEEPORN KONGMEESOOK, M.D.CHULEEPORN KONGMEESOOK, M.D.CHULEEPORN KONGMEESOOK, M.D.
  • 2. OutlineOutline •• EpidemiologyEpidemiology •• Clinical featuresClinical features •• DiagnosisDiagnosis•• DiagnosisDiagnosis •• TreatmentTreatment
  • 3. EpidemiologyEpidemiology •• UnreliableUnreliable •• 11--5 cases per million per year5 cases per million per year AlexisAlexis SidoroffSidoroff ChemChem ImmunolImmunol Allergy 2012;97:139Allergy 2012;97:139––148148
  • 4. Clinical FeaturesClinical Features •• Numerous, small nonNumerous, small non--follicular,follicular, intraepidermalintraepidermal oror subcornealsubcorneal pustulespustules (<5 mm) on an(<5 mm) on an erythematouserythematous backgroundbackground •• TypicalTypical histopathologicalhistopathological changeschanges •• Fever (> 38Fever (> 38 °°C)C)•• Fever (> 38Fever (> 38 °°C)C) •• BloodBlood neutrophilneutrophil counts > 7counts > 7 ×× 101099/L/L •• Acute evolution with spontaneousAcute evolution with spontaneous resolution of pustules < 15 daysresolution of pustules < 15 days MarijnMarijn M.M. SpeeckaertSpeeckaert et alet al Eur J Dermatol 2010; 20 : 425Eur J Dermatol 2010; 20 : 425--3333
  • 5. AlexisAlexis SidoroffSidoroff ChemChem ImmunolImmunol Allergy 2012;97:139Allergy 2012;97:139––148148
  • 6. MajaMaja MockenhauptMockenhaupt JDDG 2009 ;7:142JDDG 2009 ;7:142––162162
  • 7. www.regiscar.uniwww.regiscar.uni--freiburg.de/diseases/agepfreiburg.de/diseases/agep
  • 8. Differential diagnosisDifferential diagnosis •• PustularPustular psoriasispsoriasis •• SubcornealSubcorneal pustularpustular dermatosisdermatosis •• PustularPustular vasculitisvasculitis•• PustularPustular vasculitisvasculitis AlexisAlexis SidoroffSidoroff et alet al JJ CutanCutan PatholPathol 2001; 28:1132001; 28:113––119119
  • 9. PustularPustular psoriasispsoriasis www.dermis.netwww.dermis.net
  • 10. SubcornealSubcorneal pustularpustular dermatosisdermatosis www.uptodate.comwww.uptodate.com
  • 11. PustularPustular vasculitisvasculitis YoshihideYoshihide Asano et alAsano et al ActaActa DermDerm VenereolVenereol 2010;90:4202010;90:420--421421
  • 12. HistopathologyHistopathology MarijnMarijn M.M. SpeeckaertSpeeckaert et alet al Eur J DermatolEur J Dermatol 20102010;;2020::425425--3333
  • 13. EtiologyEtiology •• DrugsDrugs ((9090 %%)) •• InfectionsInfections •• Other factors (spider bite, mercury,Other factors (spider bite, mercury, chemotherapy, herbal medicationschemotherapy, herbal medications))chemotherapy, herbal medicationschemotherapy, herbal medications)) AlexisAlexis SidoroffSidoroff ChemChem ImmunolImmunol AllergyAllergy 20122012;;9797::139139––148148 SuranSuran L Fernando Australasian Journal of DermatologyL Fernando Australasian Journal of Dermatology 20122012;; 5353:: 8787––9292 MarijnMarijn M.M. SpeeckaertSpeeckaert et alet al Eur J DermatolEur J Dermatol 20102010;;2020::425425--3333 SimaSima HalevyHalevy CurrCurr OpinOpin AllergyAllergy ClinClin ImmunolImmunol 20092009;;99::322322––328328
  • 14. AlexisAlexis SidoroffSidoroff et al British Journal of Dermatology 2007;157: 989et al British Journal of Dermatology 2007;157: 989––996996
  • 15. AlexisAlexis SidoroffSidoroff et al British Journal of Dermatology 2007;157: 989et al British Journal of Dermatology 2007;157: 989––996996
  • 16. AlexisAlexis SidoroffSidoroff et al British Journal of Dermatology 2007;157: 989et al British Journal of Dermatology 2007;157: 989––996996
  • 17. AlexisAlexis SidoroffSidoroff et al British Journal of Dermatology 2007;157: 989et al British Journal of Dermatology 2007;157: 989––996996
  • 18. AlexisAlexis SidoroffSidoroff et alet al JJ CutanCutan PatholPathol 2001; 28:1132001; 28:113––119119
  • 19. MinMin JeeJee ChoiChoi et al Annet al Ann DermatolDermatol 20102010;;2222::163163--169169
  • 20. DiagnosisDiagnosis •• Not standardized diagnostic toolsNot standardized diagnostic tools AlexisAlexis SidoroffSidoroff ChemChem ImmunolImmunol Allergy 2012;97:139Allergy 2012;97:139––148148 SuranSuran L Fernando Australasian Journal of Dermatology 2012; 53: 87L Fernando Australasian Journal of Dermatology 2012; 53: 87––9292
  • 21. TreatmentTreatment •• SelfSelf--limited diseaselimited disease •• Discontinue causative drugDiscontinue causative drug •• Systemic corticosteroid not necessarySystemic corticosteroid not necessary •• Antibiotics if indicateAntibiotics if indicate SuranSuran L Fernando Australasian Journal of Dermatology 2012; 53: 87L Fernando Australasian Journal of Dermatology 2012; 53: 87––9292 AlexisAlexis SidoroffSidoroff et alet al JJ CutanCutan PatholPathol 2001; 28:1132001; 28:113––119119
  • 22. THANK YOUTHANK YOUTHANK YOUTHANK YOUTHANK YOUTHANK YOUTHANK YOUTHANK YOU
  • 23. PathophysiologyPathophysiology MarijnMarijn M.M. SpeeckaertSpeeckaert et alet al Eur J DermatolEur J Dermatol 20102010;; 2020 :: 425425--3333
  • 24. MajaMaja MockenhauptMockenhaupt JDDGJDDG 20092009 ;;77::142142––162162
  • 25. MajaMaja MockenhauptMockenhaupt JDDG 2009 ;7:142JDDG 2009 ;7:142––162162
  • 26. MarijnMarijn M.M. SpeeckaertSpeeckaert et alet al Eur J DermatolEur J Dermatol 20102010;;2020::425425--3333
  • 27. MarijnMarijn M.M. SpeeckaertSpeeckaert et alet al Eur J DermatolEur J Dermatol 20102010;;2020::425425--3333

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