Ca larynx

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cancer of the throat

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Ca larynx

  1. 1. 1
  2. 2.  Anatomy  Incidence  Risk factors  Symptoms  Subtypes  Staging  Diagnosis  Treatment 2
  3. 3. ANATOMY OF THE LARYNX The larynx is an organ in the throat. It’s at the front of your neck. It’s cartilages. * It consists of three main parts.* It has 2 groups of muscles Extrinsic & Intrinsic.
  4. 4. CANCER CELLS
  5. 5. INCIDENCE  Larynx CA. is the most common head & neck cancer.  Male: female = 4:1  >90% squamous cell cancer.  Glottic CA most common in Caucasian.  Glottic CA = supraglottic in African American.
  6. 6. RISK FACTORS  Tobacco smoking  Alcohol  HPV infection in the throat  The backward flow of liquid from the stomach to the throat.
  7. 7. SYMPTOMS 1- Changes to voice .2- Swelling or lump in neck or throat .3- Difficulty swallowing .4- Earache that doesn’t get better 5- Feeling breathless. .6- Cough that doesn’t go away 9
  8. 8. SUBTYPES 1- Supraglottic cancer : 40% 2- Glottic cancer : 59% 3- Subglottic cancer: 1% 10
  9. 9. STAGING 11 Early cancer: Stage 0, 1, or 2 Stage 0 Stage 1
  10. 10. STAGING Advanced cancer: Stage 3 or 4 Stage 3 12
  11. 11. 13
  12. 12. DIAGNOSIS  History  Physical examination
  13. 13.  Indirect laryngoscopy  Direct laryngoscopy  Biopsy
  14. 14. CT and MRI
  15. 15. TREATMENT 20 Before Treatment
  16. 16. TREATMENT Methods: 1. Radiotherapy 2. Chemotherapy 3. Targeted therapy 4. Surgery Choice of Treatment 21
  17. 17. Radiotherapy  When is it used?  Side effects 22
  18. 18. 23
  19. 19. Chemotherapy  For patients of advanced stage laryngeal cancer  Side effects 24
  20. 20. Targeted Therapy  Maybe given with radiotherapy  Much more specific than chemotherapy  Cetuximab: the first approved targeted therapy for Laryngeal cancer 25
  21. 21. SURGICAL OPTIONS 26
  22. 22.  Trans- oral laser microsurgery  Laryngectomy  Partial laryngectomy  Total laryngectomy 27 Surgery
  23. 23. TOTAL LARYNGECTOMY Indications:  T3 or T4 unfit for partial  Extensive involvement of thyroid and cricoid cartilages  Invasion of neck soft tissues 28
  24. 24. Total laryngectomy specimen 29
  25. 25. 30
  26. 26. Post total laryngectomy 31
  27. 27. VOICE RESTORATION  Esophageal speech  Tracheo-esophageal puncture  Electrolarynx 32
  28. 28. Esophageal speech 33
  29. 29. Tracheo-esophageal puncture (TEP) 34
  30. 30. 35
  31. 31. Electrolarynx 36
  32. 32. 37

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