This document describes foot-and-mouth disease, an infectious viral disease that affects horses and cattle. The disease is characterized by the formation of vesicles or blisters in the mouth and on the feet. Clinical signs include vesicles on the tongue, lips, dental pad, udder, and teats as well as lameness, fever, depression, anorexia, and excessive salivation. The disease should be differentiated from other conditions that cause similar vesicular lesions as well as from pox and herpes viruses. Treatment is the same as for foot-and-mouth disease.