Your SlideShare is downloading. ×
0
PARKINSON’S DISEASE
Alam Zeb
Roll no.09
Parkinsonism is a progressive
degenerative,disorder of muscle movement,
due to dysfunction in basal ganglia.
four cardinal...
 Degeneration of neurons in
the substantia nigra pars
compacta.
 Degeneration of nigrostriatal
(dopaminergic) tract
 Im...
 Drugs that replace dopamine (Dopamine
precursor):
Levodopa
 Dopa-decarboxylase inhibitors (Drugs which
increase the cen...
Parkinson by amir
Parkinson by amir
Parkinson by amir
Parkinson by amir
Parkinson by amir
Upcoming SlideShare
Loading in...5
×

Parkinson by amir

101

Published on

Parkinson's Disease

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
101
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
1
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Transcript of "Parkinson by amir"

  1. 1. PARKINSON’S DISEASE Alam Zeb Roll no.09
  2. 2. Parkinsonism is a progressive degenerative,disorder of muscle movement, due to dysfunction in basal ganglia. four cardinal features: 1.Bradykinesia or hypokinesia 2.Muscle rigidity 3.Resting tremor 4.Impairment of postural balance leading to disturbances of gait, and falling.  The secondary manifestations are mask-like face, difficulty in speech, slowing of mental process and dementia. 2
  3. 3.  Degeneration of neurons in the substantia nigra pars compacta.  Degeneration of nigrostriatal (dopaminergic) tract  Imbalance primarily between the excitatory neurotransmitter Acetylcholine and inhibitory neurotransmitter Dopamine in the Basal Ganglia.
  4. 4.  Drugs that replace dopamine (Dopamine precursor): Levodopa  Dopa-decarboxylase inhibitors (Drugs which increase the central availability of Levodopa) Carbidopa They act in the periphery as they do not enter brain  Drugs which increase release or inhibit reuptake of dopamine (also called dopamine facilitator) Amantadine 9
  1. A particular slide catching your eye?

    Clipping is a handy way to collect important slides you want to go back to later.

×