Parkinson by amir
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  • 1. PARKINSON’S DISEASE Alam Zeb Roll no.09
  • 2. Parkinsonism is a progressive degenerative,disorder of muscle movement, due to dysfunction in basal ganglia. four cardinal features: 1.Bradykinesia or hypokinesia 2.Muscle rigidity 3.Resting tremor 4.Impairment of postural balance leading to disturbances of gait, and falling.  The secondary manifestations are mask-like face, difficulty in speech, slowing of mental process and dementia. 2
  • 3.  Degeneration of neurons in the substantia nigra pars compacta.  Degeneration of nigrostriatal (dopaminergic) tract  Imbalance primarily between the excitatory neurotransmitter Acetylcholine and inhibitory neurotransmitter Dopamine in the Basal Ganglia.
  • 4.  Drugs that replace dopamine (Dopamine precursor): Levodopa  Dopa-decarboxylase inhibitors (Drugs which increase the central availability of Levodopa) Carbidopa They act in the periphery as they do not enter brain  Drugs which increase release or inhibit reuptake of dopamine (also called dopamine facilitator) Amantadine 9