Autism and behavioural disorders are no longer considered brain disorders. A more appropriate ‘whole body disorder’ perspective has come about after extensive research, with Martha Herbert MD PhD being the first to describe it this way. A complex set of factors influence Autism, ADD and mood disorders; such as toxins, environmental factors, digestive health and inflammation. All of these exert different effects on the brain and symptoms associated with these disorders.There a number of factors that we will discuss in regards to this; these include:YeastInflammationMethylationToxicity and DetoxificationOpiatesAnd most importantly of all…Poor digestion
According to Hippocrates – ‘all disease begins in the gut’. And certainly this is true with the disorders we are talking about today. (ADD, autism, anxiety etc). Digestion and gut health affect the overall health of the individual as well as affecting the brain.Our gut is one of the most important organs in the body; responsible for the breakdown and absorption of nutrients, immune function and elimination of wastes.If digestive system is working properly then the symptoms that are often experienced by patients can be markedly reduced if not eliminated.So it makes sense to support digestion and GI health in all mood disorders
Some autistic children given a dose of antibiotics enjoyed a marked short-term improvement, say US scientists. However, their autistic symptoms returned shortly after the drugs were stopped. The study, carried out at the Rush-Presbyterian-St Luke's Medical Center in Chicago, is being presented as evidence that disruption in gut bacteria was a cause of certain cases of autism. Autism affects approximately one child in 150, develops usually before the child is two years old. It involves loss of language, social and play skills. Only a small number of children were treated, all of whom had been found to have a particular type of bacterium colonising their guts. Bacterial neurotoxinThese bacteria produces a toxin which scientists theorised might be affecting their brains. The children were given an antibiotic targeted at this bacterium - nine out of the 11 treated enjoyed improved cognitive function, behaviour and social skills. Seeing most of these children apparently improve significantly was very excitingDr Richard Sandler The study team described the improvements in some cases as "impressive". Dr Richard Sandler, director of paediatric gastroenterology at Rush Children's Hospital, who led the study, said: "Autism is a devastating disorder with essentially no meaningful treatment. "Seeing most of these children apparently improve significantly was very exciting. "The next step, besides repeating clinical studies, is to go to the lab and try and find out why these effects may have been observed." Unfortunately, once the treatment stopped, the symptoms reasserted themselves. The research was sparked by the work of a Ellen Bolte, the mother of an autistic child, who developed the condition at 19 months old following several months of broad-spectrum antibiotic treatment for excess fluid in the inner ear. She reasoned that the initial antibiotic treatment had disrupted the natural bacteria which line the gut - called the intestinal flora. With this "damaged", other bacteria which could produce harmful toxins could get a foothold and colonise the gut. She said: "It was not long ago that patients diagnosed with peptic ulcers were advised to watch their diet and reduce stress. "Now, it is well-established that most peptic ulders are caused by Helicobacter pylori - a bacteria - and can be cured by antibiotic treatment."
Beneficial bacteria in the gastrointestinal system are responsible for the digestion and absorption of nutrients from food, they reduce inflammation, they inhibit the growth of harmful bacteria and pathogens. They also support the immune system and keep us disease free. Negative bacterial overgrowths are responsible for many gut disturbances. Such as constipation, diarrhoea, stomach pains, gas, and bloating In addition to causing damaging local effects to the gut tissue, abnormal bacteria have been shown to affect the brain. Probably because of GI inflammation and abnormal immune function, children with autism have abnormal levels of harmful bowel organisms. Frequent antibiotic use in the first years of life can contribute to the chronic imbalance referred to as intestinal dysbiosis. This is when the balance of bad or negative bacteria out weights that of the good bacteria.It has been documented in the literature that children with autism and behavioural disorders often have elevated levels of potentially harmful and toxin producing bacteria in the GI tract. The most common of these is from the Colstridium family. Others are often found in the bowel including Streptococcus.So what do we see in our kids with behavioural disorders?Abnormal stools are a huge tip off that there is abnormal bacteria growing. Fevers that come and go where the immune system is trying to fight the bacteria, alsoPersistent nasal congestion or cough, and behaviours that are abnormal
Candida is a type of yeast. We all have it; it occurs naturally, though normally in small amounts. The problem with Candida is, when the immune system is compromised in any way, Candida can get out of control and grow.When there is a problem with yeast overgrowth in the body, toxic by products enter the blood stream and make their way to the brain where they can cause symptoms such as inattention, ‘spaciness’, concentration problems and emotional ups and downs. These by products are substances such as alcohol, carbon dioxide gas and other toxins. No wonder we see so many people who are fatigued, they feel ‘out of it’ and have lots of gas!We commonly see yeast infections in children who are ‘run down’ and have recurring infections. Often they crave sugars and carbohydrate laden foods and this will be the only thing they want to eat! Bread, cereal, pasta and more bread, for example. They also may have been treated with antibiotics early in life on more than one occasion. Yeast infections are best treated with anti-fungals, as well as diet modifications, and immune enhancing supplements.
Parasites are opportunistic organisms, that have adverse effects on the human body. Infestation can occur in typically clean environments from even the most cautious of parents. Basically everyone is susceptible to infection from parasites, bacteria and fungus.How parasites affect brain functionParasites often excrete toxins to increase their chance of survival. These toxins will often change blood PH allowing the parasite to multiply and maintain its perfect host environment. Toxic excretions effect many bodily functions in the human body, especially immunological and neurological function. The toxins excreted can cross the blood brain barrier and create inflammation in the brain. They can also slow down and inhibit immune function, affect concentration, comprehension and creating brain fog.
It is the break down of tight junctions in the intestinal wall, allowing molecules of undigested food and proteins to pass through the gut wall into the blood stream. This can lead to immune activation and tissue damage through inflammation also affecting the brain function.We are more prone to developing leaky gut through infections such as viruses, parasites, bacteria and yeast. We can also develop leaky gut through stress, inflammation, food intolerances and allergies, antibiotics, medications and a lack of good bacteria. Many parents have reported that their children’s behaviour improved when they put their child on a gluten free casein free diet. These proteins found in grains and dairy, have been found to be highly immune reactive, particularly those with GI symptoms.There is also strong evidence that parts of these protein molecules act directly on the opiate receptors on the brain. Improved language and cognition can be achieved when on this dietOne hypothesis is that these opioids disrupt the function of the brain, creating or contributing to behaviours such as decreased socialisation, decreased response to pain, abnormal language and self abusive or repetitive behaviours.
Its frequently observed that children with Autism do not have normal stools. Constipation and/or diarrhoea are common. Often with undigested food and can be quite smelly. With constipation - stools can be infrequent or difficult to pass. Loose stools or diarrhoea are the most common stool pattern, reported by a large Gastroenterology referral centre in America, with 78% of children affected.Studies show probiotics can shorten the duration of acute diarrhoea in children, eradicate Colstridiumdifficile, decrease food derived inflammation markers and reduce symptoms of lactose intolerance and milk allergies
Inflammation in the gut and brain can be caused by toxins, food sensitivities, bacteria or yeast in the gut this can cause pain that affects behaviour. Examples being self injury, head banging and eye poking are common signs.Inflammation doesn’t just affect one area of the body. When one part of the body is inflamed it sends out immune messengers that travel throughout the body. These trigger inflammation in areas such as joints, mucus membranes of the lungs and gut and even the brain. These create more inflammation. All of this inflammation leads to allergies which of course cause even more inflammation.It is the common denominator in many conditions such as eczema, hayfever, food allergies and is a major component of dysbiosis, immune dysfunction, autism, ADHD and asthma. Things that cause inflammation include…Food, vaccinations, stress, and infection.
Anger,SocialisationIsolationInstitutionalisedNeurdegenerationAlzhimersMetal retardationMetal disorderDepressionAnxietySelf confidence issuesChronic FatigueInflamatory conditions, FM arthritis
Brief out line of the tests that we do, and why we need to monitor and retest childBaseline and monitor treatment.
Digestive Enzymes Low Hydrochloric Acid Parasites, bacteria and fungus Gut dysbiosis and leaky gut Digestive disorders Allergens- how food can affect gut and immune system and associated disorders such as asthma and skin conditions How Poor digestive function affects mood and behavior
Proper digestion is absolutely critical for good health. Your body requires efficient elimination of wastes to maintain well-being and energy levels. Indigestion is the most common physiological disorder in humans and as you might guess, There are three stages to the digestive process and all must be in good working order for good health, but there are commonly problems at each step along the way. o First, there is indigestion, which begins in the mouth and goes on down to the stomach and into the small intestines. o Next, there is reduced absorption, which takes place in the small intestines. o Lastly, there is lower bowel constipation, which can show up as diarrhoea, infrequent bowel movements, bloating, or foul gas. How do we know that we might not be digesting our food properly? o Foul smelling stools, gas, Bloating , distension, acid reflux, constipation, diarrhoea, belching, undigested food in the stools, off coloured stools What can we do about it? o Increase our Hydrochloric acid in our gut, • apple cider vinegar or lemon juice in water before meals, • Increase B6 and protein in diet.
What are enzymes?These are protein like substances, formed in animal and plant cells, that act as catalysts to initiateor speed up specific chemical reactions within the cells. We have trillions of enzymes, and as theycomplete their function they die. Enzymes are in every cell of our body, performing vital functionsevery milli-second. Where do they come from?All living cells contain enzymes - they are the "spark of life" in the cells. We are born with a "bank ofenzymes". Although, to some degree, we can replenish enzymes by manufacturing metabolicenzymes in the liver and digestive enzymes in the pancreas (primarily for protein digestion), thenumber of enzymes each cell can produce is limited. Most of the enzymes needed for digestionshould come from food. What do enzymes do and why are they so important?These tiny substances are vital to all cellular activity in our bodies. Your heart, lungs, liver, eyes, skin,glands - every organ, tissue and cell in your body are dependent upon enzymes for every processand function. Enzymes help prevent degenerative disease, keep us youthful, increase our energy.Digestive enzymes break down food and insure complete digestion and assimilation of nutrients.When our enzyme bank is depleted, we die, so we want to be sure they are not wasted.
How can enzymes be wasted?When we eat foods that dont contain digestive enzymes, our body must use itslimited supply of metabolic enzymes to digest our food, for digestion is thebodys main priority Digestive enzymes are supposed to come from food. Our bodies cannot make up for the amount of enzymes needed to digest the average meal. Why dont most of our foods contain enzymes?Cooked, processed and chemical laden foods do not contain enzymes. Evenpeople who eat healthfully include cooked foods in their diet, for some foodsmust be cooked. Also, "live" foods (raw fruits, vegetables, etc.) that are notorganically grown dont contain enough enzymes. Not only do many of our foods not contain the necessary digestive enzymes, they --especially all "junk foods" -- use up an excessive amount of your metabolic enzymes as your body attempts to digest these "foodless foods".
What happens when we dont have enough enzymes for digestion?We experience digestive problems of all kinds, usually with gas, pain anddiscomfort. Essential nutrients are not assimilated and lack of nutrientsleads to disease. In addition, incomplete digestion causes toxicity fromundigested food particles and toxicity also leads to disease. Perhaps themost serious result of lack of enzymes and incomplete digestion is aweakened immune system. Many people, who would benefit from taking digestive enzymes, are taking over-the-counter medicine for digestive disturbances and what is commonly called "heartburn". These are harmful, and in fact, until recently, some of the more powerful ones could only be obtained by prescription. These medicines block the production of hydrochloric acid, which is essential for the digestion of minerals and protein. (In addition, hydrochloric acid is our first line of defence against harmful bacteria…but thats a different article.)
Protease,helps digest proteins. Un-digested proteins wind up in circulatory system and other parts of your body.Food Sources: Broccoli, Figs, Guava, Ginger root, Green plants, Kiwi, Mushrooms, Papaya, Pineapple,Romaine lettuce, Spinach, Soy bean, Wheat, Kidney beans Amylase,helps digest carbohydrates. Incomplete digestion can cause blood sugar imbalances, allergies, and asthmaFood sources: Banana, Beets (roots, leaves and stems), Cabbage, Reishi mushrooms, Sweet potatoEgg, Maple sap, Milk, Honey, Sugar-cane, Barley, Corn, Oats, Rice, Wheat, Kidney beans Lipase,helps digest fat. Incomplete digestion can lead to clogged arteries causing blood pressure and heartproblems.Food Sources: Avocado, Coconuts, Corn, Flaxseeds, Raw red meats, Romaine Lettuce, Spinach, Wheatgerm ,Rice, Soybeans, Rape seeds Cellulase,Helps break down cellulose (soluble fiber). Helps bind heavy metal and toxins to be expelled out of bodyFood Sources. Avocado, Peas, Reishi mushrooms, Oat sprouts,
Maltase,Helps convert complex sugar found in malt and grain products into glucoseFood Sources: Banana, Beet leaves, Green plants, Brewers’s yeast, Mushroom, Sugar-cane, Rice, Lactase,Helps digest lactose found in dairy productsFood Sources. Almonds, Apples, Peaches, Persimmons, Tomatoes, Milk. Sucrase,Helps digest sucrose including table sugarFood Sources. Cucumbers, Potato, Romaine Lettuce, Spinach, Sugar-cane Alpha Galatosidase,Hydrolyzes sugars in beans that ferment and cause gas. This enzyme is in the Bean-o ,Helps prevent gas.Food Sources: Cucumbers, Sprouted legumes (soy beans, cowpeas) Phytase,Helps digest Phytic acid (Phytate) found in Grains and Seeds releasing phosphorus, calcium and other nutrients
Hydrochloric acid helps break down proteins and also plays an important role in signalling to the pancreas to release digestive enzymes and bicarbonate. HCl helps sterilize stomach contents so that bad bacteria cannot hitch a ride into the small intestine for invasive and destructive colonization. Plenty of folks over 40 or 50 have insufficient HCl for digestion; heartburn is often linked to low HCl levels and over-the-counter medicines only address the symptom and not the root cause and can lead to poor digestion, dysbiosis, leaky gut and allergies.
Hypochlorhydria is the lack of adequate stomach acid (hydrochloric acid) production Insufficient stomach acid also causes absorption of partially digested food molecules, leading to food sensitivities. Low stomach acid increases the overgrowth of pathogens in the lower intestine. Malabsorbtion of minerals vitamins and amino acids and increases the chances of food sensitivities.
Stomach aching/pain/discomfort or Multiple food sensitivities bloating after meals Trouble digesting red meat Feel unwell/fatigued right after meals Food or water sits in stomach Constipation High fat foods cause Low iron levels nausea/stomach upset Frequent nausea Undigested food in stool Nausea/reflux after supplements (e.g. Reflux &/or heartburn fish oil) Poor appetite or feel overly full easily Burping after meals
What are they? Bacteria &Yeast Microbes & Parasites Intestinal Permeability (‘Leaky gut’) Inflammation Constipation & Diarrhoea Food Sensitivities and Allergens
Bacteria What do they do? Can they effect brain function? Why treating with Antibiotics does not work? Signs and symptoms of bacterial infection… Abnormal stools, fevers that come and go, persistent nasal congestion or cough, and behaviours that are abnormal
What is yeast? What are the symptoms? Itching, rashes, eczema, abdominal bloating, increase in flatulence, constipation or diarrhoea, smelly stool; silly/giddy behavior, aggressive, stimming, chewing - on anything, low energy, cravings for bread, pasta and sweets Why do we get it? How do we treat it?
Dr William Shaw (an Autism specialist) has also suggested an association between Autistic symptoms and yeast overgrowth in the bowel. Children with mood disorders could be vulnerable either because of larger than normal yeast populations or an impaired capacity to detox the yeast by products. Many parents and physicians report improvement in both GI and behavioural symptoms in children with the use of antifungals (which kill yeast) (Jepson B, MD. Changing the course of Autism. p98, 2007)
What is a parasite? Where do we get them from? Signs and Symptoms of a parasitic infection… Allergies, Headaches, Anxiety, Depression, Comprehension difficulty, Brain Fog, Gas and bloating, Constipation, Diarrhoea, Foul smelling stools, Chronic fatigue, low energy or hyperactivity, Flu symptoms, fever and aches, Poor Immune function, Sleep disturbances, Grinding teeth at night, Vision problems, Anaemia, Eczema, Rashes and itchy back passage, Weight gain or loss
Headaches, “heavy head,” “heavy-feeling headaches.” Alternated periods of mental “fuzziness” and greater mental clarity. Feeling “muggy-headed” or “blah” or sick in the morning. Transient malaise, flu-like symptoms. Transiently increased fatigue, waxing and waning fatigue, feeling more tired and sluggish, weakness. Dizziness. Irritability. Sensation of “brain firing: bing, bong, bing, bong,” “brain moving very fast.” Depression, feeling overwhelmed, strong emotions. Greater need for “healing naps.” Swollen or painful lymph nodes. Runny nose, low grade “sniffles,” sneezing, coughing.
A study that assessed SIBO in test subjects, found that84% of irritable bowel syndrome sufferers, 77% ofchronic fatigue patients and 100% of fibromyalgia (FM)sufferers had this small bowel dysbiotic overgrowth.A further study of FM patients revealed that eradicationof SIBO significantly decreased overall pain, abdominalbloating, wind, constipation, diarrhoea, joint pain andfatigue.
• bloating• abdominal distension• abdominal pain or discomfort• diarrhoea• fatigue and weakness• malabsorption syndrome• nutritional deficiencies• metabolic bone disorders e.g. osteoporosis
What is it? How does this happen? How does it affect the brain and mood? behaviours such as decreased socialisation, decreased response to pain, abnormal language and self abusive or repetitive behaviours
Afzal and others report a high frequency of both constipation and loose stools in children with Autism & mood disorders, suggesting a bowel motility disorder Afzal et al, Constipation and acquired megarectum in children with Autism. Paediatrics. 2003 Oct;112(4):939-42 Can probiotics help? Studies show probiotics can shorten the duration of acute diarrhoea in children, eradicate Colstridium difficile, decrease food derived inflammation markers and reduce symptoms of lactose intolerance and milk allergies
Turns out the runny nose and itchy eyes could actually be affecting your mood and even be exacerbating your risk for depression.Doctors agree theres a real connection between allergies and mood, researchalso shows there is about a doubling of risk for depression in a person sufferingallergies -- and those who have been seen by an allergist are three times morelikely of having depression. BUT WHY?
Although allergies do not cause clinical depression, they cause mood changesthat result in the physiological symptoms of mild depression, leading to overallfeelings of sadness, lethargy, and fatigue. And those who already suffer fromdepression, their symptoms worsen with the allergy.An allergic reaction brings about the release of cytokines in the body that bringson the feeling of being ill and ‘mentally drained.’ Earlier studies, had proved thatallergies triggered off by pollen caused fatigue and mood changes and sloweddown cognitive processing.Allergies/sensitivities create inflammatoryprocess’s in the gut wall which lead to inflammation.
Symptoms of food allergy include• wheezing• stomach upsets and• skin rashes• Bloating• Gastrointestinal pain and gas• Mood and behavioural disturbancesSymptoms of food intolerance are similar to food allergy, but can be associatedwith conditions including• asthma,• chronic fatigue syndrome and• irritable bowel syndrome (IBS).• ADD/ADHDSome food allergens include nuts, gluten and wheat, casein, shellfish, milk, eggand soy products.
In an inflammatory attack, immune cells rev each other up by pumping outsubstances known as inflammatory cytokinesThe first inkling of a connection between mood and inflammation camearound 1990. Michael Maes, a psychiatrist now at the University of Maastrichtin the Netherlands, was investigating claims that depressed people areunusually vulnerable to infections and cancer, a theory that could beexplained by a lacklustre immune system.But when Maes looked at immune cells from depressed people such asnatural-killer cells, monocytes and macrophages, he found instead that thecells were more active than normal, and spewed out more inflammatorycytokines. "We had expected to find just the opposite," admits Maes.Summary, Immune activation leads to Inflammation systemically especially inthe brain.
Inflammation What causes it? How does it affect the brain and mood? What conditions involve inflammation? eczema, hayfever, food allergies, dysbiosis, immune dysfunction, Autism, ADHD and asthma
Socialimplications on the Child and into Adulthood Long term health problems. IBS, inflammatory diseases Increased prevalence of illness, Immune dysfunction/suppression Learning difficulties Autism ADD/ADHD
Urinary Indican Test Blood Tests Pathology Live Blood Screening CDSA (Complete digestive stool analysis) Allergy testing Stool test Microbiology testing for specific parasites stool test
“This study is the firstto show that theprobioticsL.acidophilus NCFM …neither B.lactis& B.lactis Bi-07 BB12 or L.reuterireduce the duration & ATCC had any effectincidence of on respiratoryrespiratory illness in illnesses in children…children”
THE RIGHT STRAIN CAN BE LIFE CHANGINGLactobacillus GG was effective in preventionof early atopic disease in children at highrisk…..The frequency of atopic eczema washalf that in the placebo group Published in “The Lancet”
Relief & prevention ofinfectious diarrhoea(bacterial & viral – 1 capsule)Prevention of eczema, allergiesand atopy(taken pre & postnatally – 2caps)
• NCFM contains; Each capsule – Helps control intestinal L.acidophillus NCFM 11.5 billion B.lactis Bi-07 11.5and bacterial pathogens billion overgrowth L.rhamnosus GG (LGG) 2 billion Restoration of gut flora – Promotes Colostrum 62mg balance of the gut immune system Maintenance of gut health – Improves NOW WITH 1 capsule daily lactose digestion LGG General digestive health • Bi-07 Re-inoculation of the 30 capsules – Improves gut immunity & gut bowel after antibiotics 60 capsules health Also available Dairy Free • LGG (without colostrum) – Strengthens gut wall, mucosa & villi
Each capsule contains: S. boullardii 7.5 billion L. rhamnosus HN001 500 million Dysbiosis (2 to 4 caps) 2 to 4 capsules daily Traveller’s diarrhoea (2 caps) 60 capsules Candida Overgrowth (4 caps)
Presenting with Results Child 3 years of age Frequent and normal stools Constipation Reduction in skin dermatitis eczema Diarrhoea Normal temperature Reoccurring infections Less waking at nights Allergies Better appetite, especially in the mornings Rashes No pain Regular high temps Less gas Morning Nausea Stomach pain Retesting Indicans ClearTests Microbiology Clear Indicans test +3green Microbiology test(positive clostridium, Helicobacter worms) Low Bifido bacteriumTreatment Herbal antibacterial ant parasitic medication Followed by specific probiotic for candida/immune and gut function repair Vit C Zinc Changed diet to remove Dairy and gluten Increased Fibre and protein
Presenting with Out come 32 year old female No pain on defecation Fatigue Increased energy IBS Diagnosed Acne cleared Allergies to Milk & Grass Less gas Frequent sinus/chest infection Noticed more gas when she ate dairy on occasions Headaches Only occasional headaches Bloating, Gas Pain on defecation Testing Acne on face and back Indican (+1 yellow) Continued to retest and keep on a program ofTesting supplementation for bowel and gut repair Indican urinalysis (+ 3 yellow) Metametrix Allergy testing (positive casein, wheat)Treatment Herbal Parasite and bacterial cleanse Colostrinun based supplementation VitC & Zinc Followed by specific probiotic supplementation Anti inflammatory gut mucosa healing supplement Aloe Vera Juice Removed dairy and Wheat from diet.