SlideShare a Scribd company logo
1 of 10
Download to read offline
Caroli 
disease 
Ahmed Abdulghany
In 1958, Jacques Caroli first described a rare 
congenital condition in which there was a non-obstructive 
saccular dilatation of large intrahepatic 
bile ducts. 
Caroli Syndrome: more common variable in which 
bile duct dilatation is associated with congenital 
hepatic fibrosis
Genetics 
Incompletely understood however gene for 
autosomal recessive polycystic kidney disease has 
been linked to caroli disease coding for Fibrocystin.
Clinical manifestations 
There are several modes of presentations 
depending on the age of onset and predominance of 
hepatic or renal involvement. 
Biliary dilation predispose to biliary stagnation and 
stone formation. 
Bacterial cholangitis occur frequently and may be 
complicated by septicemia.
Diagnosis 
Established by imaging studies (US & MRCP) 
showing irregular, cystic dilation of proximal 
intrahepatic bile ducts with normal common bile 
duct.
Liver functions show mild cholestatic pattern 
Liver biopsy is rarely required for diagnosis
Differential diagnosis 
1ry biliary cirrhosis 
1ry sclerosing 
cholangitis 
Drug induced 
cholestasis 
Intrahepatic 
cholestasis of 
pregnancy 
Sarcoidosis 
Amyloidosis 
Infiltrating neoplasms
Treatment 
Supportive 
Complications as cholangitis and portal 
hypertension 
Liver transplantation for recurrent cholangitis
Prognosis 
Variable depending upon severity of the disease 
and presence of coexisting renal dysfunction. 
Although risk of cholangiocarcinoma is up to 7%, 
surveillance is unclear. Suspect if there is 
unexplained clinical deterioration or development 
of new biliary strictures.
Thank you

More Related Content

What's hot (20)

Obstructive jaundice 1
Obstructive jaundice 1Obstructive jaundice 1
Obstructive jaundice 1
 
Upper GI Hemorrhage-- Surgical perspective
Upper GI Hemorrhage-- Surgical perspectiveUpper GI Hemorrhage-- Surgical perspective
Upper GI Hemorrhage-- Surgical perspective
 
Neonatal intestinal obstruction
Neonatal intestinal obstructionNeonatal intestinal obstruction
Neonatal intestinal obstruction
 
periampullary carcinoma
periampullary carcinomaperiampullary carcinoma
periampullary carcinoma
 
Obstructive jaundice
Obstructive jaundiceObstructive jaundice
Obstructive jaundice
 
Barretts oesophagus
Barretts oesophagusBarretts oesophagus
Barretts oesophagus
 
Acute pancreatitis surgery seminar
Acute pancreatitis surgery seminarAcute pancreatitis surgery seminar
Acute pancreatitis surgery seminar
 
Meckel’s diverticulum
Meckel’s diverticulumMeckel’s diverticulum
Meckel’s diverticulum
 
9 hernia
9 hernia9 hernia
9 hernia
 
Cholangitis
CholangitisCholangitis
Cholangitis
 
Obstructive jaundice
Obstructive jaundiceObstructive jaundice
Obstructive jaundice
 
Gastric outlet obstruction
Gastric outlet obstruction Gastric outlet obstruction
Gastric outlet obstruction
 
Enterocutaneous fistulas
Enterocutaneous fistulasEnterocutaneous fistulas
Enterocutaneous fistulas
 
Gastric cancer
Gastric cancerGastric cancer
Gastric cancer
 
FOURNIER'S GANGRENE
FOURNIER'S GANGRENEFOURNIER'S GANGRENE
FOURNIER'S GANGRENE
 
Paget disease of the breast
Paget disease of the breastPaget disease of the breast
Paget disease of the breast
 
Surgical Jaundice
Surgical JaundiceSurgical Jaundice
Surgical Jaundice
 
Gastric outlet obstruction
Gastric outlet obstructionGastric outlet obstruction
Gastric outlet obstruction
 
Cholecystitis
CholecystitisCholecystitis
Cholecystitis
 
Acute cholecystitis.pptx
Acute cholecystitis.pptxAcute cholecystitis.pptx
Acute cholecystitis.pptx
 

Viewers also liked

Git and hepatobiliary radiology mocks fcps
Git and hepatobiliary radiology mocks fcpsGit and hepatobiliary radiology mocks fcps
Git and hepatobiliary radiology mocks fcpsdrneelammalik
 
Pediatric liver masses
Pediatric liver massesPediatric liver masses
Pediatric liver massesSidra Afzal
 
Biliary atresia- Obstructive jaundice/ Pediatric surgery
Biliary atresia- Obstructive jaundice/ Pediatric surgeryBiliary atresia- Obstructive jaundice/ Pediatric surgery
Biliary atresia- Obstructive jaundice/ Pediatric surgerySelvaraj Balasubramani
 
Cholelithiasis:Early diagnosis and prompt treatment.
Cholelithiasis:Early diagnosis and prompt treatment.Cholelithiasis:Early diagnosis and prompt treatment.
Cholelithiasis:Early diagnosis and prompt treatment.KETAN VAGHOLKAR
 
Biliary tract
Biliary tractBiliary tract
Biliary tractairwave12
 
Case study on cholelithiasis
Case study on cholelithiasisCase study on cholelithiasis
Case study on cholelithiasiseducation4227
 
Gallstone presentation
Gallstone presentation Gallstone presentation
Gallstone presentation HAMAD DHUHAYR
 
Cholelithiasis final year lecture
Cholelithiasis   final year lectureCholelithiasis   final year lecture
Cholelithiasis final year lectureMr Adeel Abbas
 
Ultrasound of acute & chronic cholecystitis
Ultrasound of acute & chronic cholecystitisUltrasound of acute & chronic cholecystitis
Ultrasound of acute & chronic cholecystitisSamir Haffar
 
Ultrasound of the gallbladder
Ultrasound of the gallbladderUltrasound of the gallbladder
Ultrasound of the gallbladderSamir Haffar
 

Viewers also liked (19)

Git and hepatobiliary radiology mocks fcps
Git and hepatobiliary radiology mocks fcpsGit and hepatobiliary radiology mocks fcps
Git and hepatobiliary radiology mocks fcps
 
Pediatric liver masses
Pediatric liver massesPediatric liver masses
Pediatric liver masses
 
Choledochal cyst
Choledochal cystCholedochal cyst
Choledochal cyst
 
Choledochal cysts - Introduction, Classification, Pathogenesis & Management
Choledochal cysts - Introduction, Classification, Pathogenesis & ManagementCholedochal cysts - Introduction, Classification, Pathogenesis & Management
Choledochal cysts - Introduction, Classification, Pathogenesis & Management
 
Choledochal cyst
Choledochal cystCholedochal cyst
Choledochal cyst
 
Gallbladder, The Big Picture
Gallbladder, The Big PictureGallbladder, The Big Picture
Gallbladder, The Big Picture
 
Gallstones
GallstonesGallstones
Gallstones
 
Biliary atresia- Obstructive jaundice/ Pediatric surgery
Biliary atresia- Obstructive jaundice/ Pediatric surgeryBiliary atresia- Obstructive jaundice/ Pediatric surgery
Biliary atresia- Obstructive jaundice/ Pediatric surgery
 
Gall stones
Gall stonesGall stones
Gall stones
 
Cholelithiasis:Early diagnosis and prompt treatment.
Cholelithiasis:Early diagnosis and prompt treatment.Cholelithiasis:Early diagnosis and prompt treatment.
Cholelithiasis:Early diagnosis and prompt treatment.
 
Biliary tract
Biliary tractBiliary tract
Biliary tract
 
Case study on cholelithiasis
Case study on cholelithiasisCase study on cholelithiasis
Case study on cholelithiasis
 
Gallstone
GallstoneGallstone
Gallstone
 
Cholelithiasis
CholelithiasisCholelithiasis
Cholelithiasis
 
Gallstone presentation
Gallstone presentation Gallstone presentation
Gallstone presentation
 
Cholelithiasis final year lecture
Cholelithiasis   final year lectureCholelithiasis   final year lecture
Cholelithiasis final year lecture
 
Ultrasound of acute & chronic cholecystitis
Ultrasound of acute & chronic cholecystitisUltrasound of acute & chronic cholecystitis
Ultrasound of acute & chronic cholecystitis
 
Biliary atresia
Biliary atresiaBiliary atresia
Biliary atresia
 
Ultrasound of the gallbladder
Ultrasound of the gallbladderUltrasound of the gallbladder
Ultrasound of the gallbladder
 

Similar to Caroli syndrome

PPT on Neonatal cholestasis by Dr.ajay k chourasia
PPT on Neonatal cholestasis  by Dr.ajay k chourasiaPPT on Neonatal cholestasis  by Dr.ajay k chourasia
PPT on Neonatal cholestasis by Dr.ajay k chourasiaAjay Kumar
 
Approach to obstructive jaundice
Approach to obstructive jaundiceApproach to obstructive jaundice
Approach to obstructive jaundicesk harish
 
Cholecystitis and Choldocholithiasis
Cholecystitis and CholdocholithiasisCholecystitis and Choldocholithiasis
Cholecystitis and CholdocholithiasisNAVANEETA KUSUM
 
Gallbladder benign conditions
Gallbladder benign conditionsGallbladder benign conditions
Gallbladder benign conditionsdoctorcool10
 
Gallbladder Disease in Children.pptx
Gallbladder Disease in Children.pptxGallbladder Disease in Children.pptx
Gallbladder Disease in Children.pptxIndraPrima3
 
Surgical jaundice in neonates 7th yr
Surgical jaundice in neonates 7th yrSurgical jaundice in neonates 7th yr
Surgical jaundice in neonates 7th yrfreeburn simunchembu
 
Obstructive jaundice in neonate.ppt
Obstructive jaundice in neonate.pptObstructive jaundice in neonate.ppt
Obstructive jaundice in neonate.pptshashi singh
 
Liver Cirrhosis.pptxgsuhsbshhshhsjjsjbbshshh
Liver Cirrhosis.pptxgsuhsbshhshhsjjsjbbshshhLiver Cirrhosis.pptxgsuhsbshhshhsjjsjbbshshh
Liver Cirrhosis.pptxgsuhsbshhshhsjjsjbbshshhssusere3aa49
 
Imaging of dangerous cholecystitis
Imaging of dangerous cholecystitisImaging of dangerous cholecystitis
Imaging of dangerous cholecystitisAhmed Bahnassy
 
Presentation cholelithiasis
Presentation cholelithiasisPresentation cholelithiasis
Presentation cholelithiasisANJANI WALIA
 
Evaluation of Jaundice by Dr. Sookun Rajeev Kumar
Evaluation of Jaundice by Dr. Sookun Rajeev KumarEvaluation of Jaundice by Dr. Sookun Rajeev Kumar
Evaluation of Jaundice by Dr. Sookun Rajeev KumarDr. Sookun Rajeev Kumar
 
CHOLECYSTITIS.pptx
CHOLECYSTITIS.pptxCHOLECYSTITIS.pptx
CHOLECYSTITIS.pptxHarmonyOyiko
 

Similar to Caroli syndrome (20)

biliary atresia
biliary atresiabiliary atresia
biliary atresia
 
Oxford Abdomen Cases.pptx
Oxford Abdomen Cases.pptxOxford Abdomen Cases.pptx
Oxford Abdomen Cases.pptx
 
PPT on Neonatal cholestasis by Dr.ajay k chourasia
PPT on Neonatal cholestasis  by Dr.ajay k chourasiaPPT on Neonatal cholestasis  by Dr.ajay k chourasia
PPT on Neonatal cholestasis by Dr.ajay k chourasia
 
Approach to obstructive jaundice
Approach to obstructive jaundiceApproach to obstructive jaundice
Approach to obstructive jaundice
 
Cholecystitis and Choldocholithiasis
Cholecystitis and CholdocholithiasisCholecystitis and Choldocholithiasis
Cholecystitis and Choldocholithiasis
 
Gallbladder benign conditions
Gallbladder benign conditionsGallbladder benign conditions
Gallbladder benign conditions
 
Gallbladder Disease in Children.pptx
Gallbladder Disease in Children.pptxGallbladder Disease in Children.pptx
Gallbladder Disease in Children.pptx
 
Neonatal cholestasis
Neonatal cholestasisNeonatal cholestasis
Neonatal cholestasis
 
Surgical jaundice
Surgical jaundiceSurgical jaundice
Surgical jaundice
 
Surgical jaundice in neonates 7th yr
Surgical jaundice in neonates 7th yrSurgical jaundice in neonates 7th yr
Surgical jaundice in neonates 7th yr
 
Gallbladder Disease in Children
Gallbladder Disease in ChildrenGallbladder Disease in Children
Gallbladder Disease in Children
 
Surgical jaundice
Surgical jaundiceSurgical jaundice
Surgical jaundice
 
Hepato Biliary.pptx
Hepato Biliary.pptxHepato Biliary.pptx
Hepato Biliary.pptx
 
OBSTRUCTIVE JAUNDICE.pptx
OBSTRUCTIVE JAUNDICE.pptxOBSTRUCTIVE JAUNDICE.pptx
OBSTRUCTIVE JAUNDICE.pptx
 
Obstructive jaundice in neonate.ppt
Obstructive jaundice in neonate.pptObstructive jaundice in neonate.ppt
Obstructive jaundice in neonate.ppt
 
Liver Cirrhosis.pptxgsuhsbshhshhsjjsjbbshshh
Liver Cirrhosis.pptxgsuhsbshhshhsjjsjbbshshhLiver Cirrhosis.pptxgsuhsbshhshhsjjsjbbshshh
Liver Cirrhosis.pptxgsuhsbshhshhsjjsjbbshshh
 
Imaging of dangerous cholecystitis
Imaging of dangerous cholecystitisImaging of dangerous cholecystitis
Imaging of dangerous cholecystitis
 
Presentation cholelithiasis
Presentation cholelithiasisPresentation cholelithiasis
Presentation cholelithiasis
 
Evaluation of Jaundice by Dr. Sookun Rajeev Kumar
Evaluation of Jaundice by Dr. Sookun Rajeev KumarEvaluation of Jaundice by Dr. Sookun Rajeev Kumar
Evaluation of Jaundice by Dr. Sookun Rajeev Kumar
 
CHOLECYSTITIS.pptx
CHOLECYSTITIS.pptxCHOLECYSTITIS.pptx
CHOLECYSTITIS.pptx
 

More from Ahmed Ghany

Bronchial asthma updated
Bronchial asthma updatedBronchial asthma updated
Bronchial asthma updatedAhmed Ghany
 
Biliary complications
Biliary complicationsBiliary complications
Biliary complicationsAhmed Ghany
 
Reversible dementia
Reversible dementiaReversible dementia
Reversible dementiaAhmed Ghany
 
Drug induced skin emergencies
Drug induced skin emergenciesDrug induced skin emergencies
Drug induced skin emergenciesAhmed Ghany
 
Toxic epidermal necrolysis (TEN)
Toxic epidermal necrolysis (TEN)Toxic epidermal necrolysis (TEN)
Toxic epidermal necrolysis (TEN)Ahmed Ghany
 
Non-selective Beta blockers
Non-selective Beta blockersNon-selective Beta blockers
Non-selective Beta blockersAhmed Ghany
 
Non-variceal bleeding in cirrhotic pt
Non-variceal bleeding in cirrhotic ptNon-variceal bleeding in cirrhotic pt
Non-variceal bleeding in cirrhotic ptAhmed Ghany
 
Budd chari differential diagnosis. ppt
Budd chari differential diagnosis. pptBudd chari differential diagnosis. ppt
Budd chari differential diagnosis. pptAhmed Ghany
 
Budd chiari syndrome01ppt
Budd chiari syndrome01pptBudd chiari syndrome01ppt
Budd chiari syndrome01pptAhmed Ghany
 
Hemolytic anemia
Hemolytic anemiaHemolytic anemia
Hemolytic anemiaAhmed Ghany
 
Budd chiari syndrome
Budd chiari syndromeBudd chiari syndrome
Budd chiari syndromeAhmed Ghany
 
Coma flowchart in adults
Coma flowchart in adultsComa flowchart in adults
Coma flowchart in adultsAhmed Ghany
 
Ecg step by step not by me
Ecg step by step not by meEcg step by step not by me
Ecg step by step not by meAhmed Ghany
 
Systemic Lupus and Abdominal Pains
Systemic Lupus and Abdominal PainsSystemic Lupus and Abdominal Pains
Systemic Lupus and Abdominal PainsAhmed Ghany
 
Multiple Myloma Diagnostic Criteria
Multiple Myloma Diagnostic CriteriaMultiple Myloma Diagnostic Criteria
Multiple Myloma Diagnostic CriteriaAhmed Ghany
 
Severe Ulcerative Colitis
Severe Ulcerative ColitisSevere Ulcerative Colitis
Severe Ulcerative ColitisAhmed Ghany
 
Tuberous Sclerosis Complex With Renal AML 2
Tuberous Sclerosis Complex With Renal AML 2Tuberous Sclerosis Complex With Renal AML 2
Tuberous Sclerosis Complex With Renal AML 2Ahmed Ghany
 
Neurocutaneous disorders
Neurocutaneous disordersNeurocutaneous disorders
Neurocutaneous disordersAhmed Ghany
 

More from Ahmed Ghany (20)

Bronchial asthma updated
Bronchial asthma updatedBronchial asthma updated
Bronchial asthma updated
 
Biliary complications
Biliary complicationsBiliary complications
Biliary complications
 
Cardiac exam
Cardiac examCardiac exam
Cardiac exam
 
Reversible dementia
Reversible dementiaReversible dementia
Reversible dementia
 
Rasopathies
RasopathiesRasopathies
Rasopathies
 
Drug induced skin emergencies
Drug induced skin emergenciesDrug induced skin emergencies
Drug induced skin emergencies
 
Toxic epidermal necrolysis (TEN)
Toxic epidermal necrolysis (TEN)Toxic epidermal necrolysis (TEN)
Toxic epidermal necrolysis (TEN)
 
Non-selective Beta blockers
Non-selective Beta blockersNon-selective Beta blockers
Non-selective Beta blockers
 
Non-variceal bleeding in cirrhotic pt
Non-variceal bleeding in cirrhotic ptNon-variceal bleeding in cirrhotic pt
Non-variceal bleeding in cirrhotic pt
 
Budd chari differential diagnosis. ppt
Budd chari differential diagnosis. pptBudd chari differential diagnosis. ppt
Budd chari differential diagnosis. ppt
 
Budd chiari syndrome01ppt
Budd chiari syndrome01pptBudd chiari syndrome01ppt
Budd chiari syndrome01ppt
 
Hemolytic anemia
Hemolytic anemiaHemolytic anemia
Hemolytic anemia
 
Budd chiari syndrome
Budd chiari syndromeBudd chiari syndrome
Budd chiari syndrome
 
Coma flowchart in adults
Coma flowchart in adultsComa flowchart in adults
Coma flowchart in adults
 
Ecg step by step not by me
Ecg step by step not by meEcg step by step not by me
Ecg step by step not by me
 
Systemic Lupus and Abdominal Pains
Systemic Lupus and Abdominal PainsSystemic Lupus and Abdominal Pains
Systemic Lupus and Abdominal Pains
 
Multiple Myloma Diagnostic Criteria
Multiple Myloma Diagnostic CriteriaMultiple Myloma Diagnostic Criteria
Multiple Myloma Diagnostic Criteria
 
Severe Ulcerative Colitis
Severe Ulcerative ColitisSevere Ulcerative Colitis
Severe Ulcerative Colitis
 
Tuberous Sclerosis Complex With Renal AML 2
Tuberous Sclerosis Complex With Renal AML 2Tuberous Sclerosis Complex With Renal AML 2
Tuberous Sclerosis Complex With Renal AML 2
 
Neurocutaneous disorders
Neurocutaneous disordersNeurocutaneous disorders
Neurocutaneous disorders
 

Recently uploaded

Human Skeletal System_By Anupam Das......
Human Skeletal System_By Anupam Das......Human Skeletal System_By Anupam Das......
Human Skeletal System_By Anupam Das......anupamdas2143
 
Brief introduction to information ecosystem x public health.pptx
Brief introduction to information ecosystem x public health.pptxBrief introduction to information ecosystem x public health.pptx
Brief introduction to information ecosystem x public health.pptxTina Purnat
 
SGK BỆNH LÝ GOUT YHN hay lắm nha aaaa.pdf
SGK BỆNH LÝ GOUT YHN hay lắm nha aaaa.pdfSGK BỆNH LÝ GOUT YHN hay lắm nha aaaa.pdf
SGK BỆNH LÝ GOUT YHN hay lắm nha aaaa.pdfHongBiThi1
 
airway management recorded for S2.pptx
airway management  recorded  for S2.pptxairway management  recorded  for S2.pptx
airway management recorded for S2.pptxnakera38
 
Thyroid function tests for MBBS, LAB. MED & BDS.pptx
Thyroid function tests for MBBS, LAB. MED & BDS.pptxThyroid function tests for MBBS, LAB. MED & BDS.pptx
Thyroid function tests for MBBS, LAB. MED & BDS.pptxRajendra Dev Bhatt
 
NECROSIS FOR MBBS FIRST YEAR STUDENTS MADE EASY.pptx
NECROSIS FOR MBBS FIRST YEAR STUDENTS MADE EASY.pptxNECROSIS FOR MBBS FIRST YEAR STUDENTS MADE EASY.pptx
NECROSIS FOR MBBS FIRST YEAR STUDENTS MADE EASY.pptxSizan Thapa
 
Derma Pharmaceutical Franchise Company - Solace Biotech Limited
Derma Pharmaceutical Franchise Company - Solace Biotech LimitedDerma Pharmaceutical Franchise Company - Solace Biotech Limited
Derma Pharmaceutical Franchise Company - Solace Biotech LimitedSBL DIGITAL
 
TARGET DELINEATION IN CERVIX CANCER BY DR KANHU
TARGET DELINEATION IN CERVIX CANCER BY DR KANHUTARGET DELINEATION IN CERVIX CANCER BY DR KANHU
TARGET DELINEATION IN CERVIX CANCER BY DR KANHUKanhu Charan
 
Ten lessons learnt as anesthetist.pptx
Ten  lessons  learnt as anesthetist.pptxTen  lessons  learnt as anesthetist.pptx
Ten lessons learnt as anesthetist.pptxtusharchokshi1
 
ANATOMY OF THE CEREBRUM WITH CLINICAL ANATOMY.pptx
ANATOMY OF THE CEREBRUM WITH CLINICAL ANATOMY.pptxANATOMY OF THE CEREBRUM WITH CLINICAL ANATOMY.pptx
ANATOMY OF THE CEREBRUM WITH CLINICAL ANATOMY.pptxsiddharthroy26587
 
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...Genesis Institute of Pharmacy, Radhanagari.
 
SGK VIÊM KHỚP DẠNG THẤP YHN .pdf
SGK VIÊM KHỚP DẠNG THẤP YHN              .pdfSGK VIÊM KHỚP DẠNG THẤP YHN              .pdf
SGK VIÊM KHỚP DẠNG THẤP YHN .pdfHongBiThi1
 
INTRODUCTION TO THE FORENSIC SCIENCE.ppt
INTRODUCTION TO THE FORENSIC SCIENCE.pptINTRODUCTION TO THE FORENSIC SCIENCE.ppt
INTRODUCTION TO THE FORENSIC SCIENCE.pptKavitha Krishnan
 
Methicillin-resistant Staphylococcus Aureus (MRSA)
Methicillin-resistant Staphylococcus Aureus (MRSA)Methicillin-resistant Staphylococcus Aureus (MRSA)
Methicillin-resistant Staphylococcus Aureus (MRSA)Ahmad Thanin
 
(IDE)and(IVD),QMS,21 CFR part820 , 801)
(IDE)and(IVD),QMS,21 CFR part820  , 801)(IDE)and(IVD),QMS,21 CFR part820  , 801)
(IDE)and(IVD),QMS,21 CFR part820 , 801)chahattyagi200
 
Neurological Evaluation of Acute Ischemic stroke in Emergency Room
Neurological Evaluation of Acute Ischemic stroke in Emergency RoomNeurological Evaluation of Acute Ischemic stroke in Emergency Room
Neurological Evaluation of Acute Ischemic stroke in Emergency RoomSudhir Kumar
 
bleeding disorders 1 Dr.Nannika Pradhan
bleeding disorders 1  Dr.Nannika Pradhanbleeding disorders 1  Dr.Nannika Pradhan
bleeding disorders 1 Dr.Nannika Pradhanthesalberry
 
TARGET DELINEATION IN RECTUM CANCER BY DR KANHU
TARGET DELINEATION IN RECTUM  CANCER BY DR KANHUTARGET DELINEATION IN RECTUM  CANCER BY DR KANHU
TARGET DELINEATION IN RECTUM CANCER BY DR KANHUKanhu Charan
 

Recently uploaded (20)

Human Skeletal System_By Anupam Das......
Human Skeletal System_By Anupam Das......Human Skeletal System_By Anupam Das......
Human Skeletal System_By Anupam Das......
 
Oral disorders .pptx
Oral disorders .pptxOral disorders .pptx
Oral disorders .pptx
 
Catalysts for Change in SCLC: Optimizing the Use of Standard Therapies and Ac...
Catalysts for Change in SCLC: Optimizing the Use of Standard Therapies and Ac...Catalysts for Change in SCLC: Optimizing the Use of Standard Therapies and Ac...
Catalysts for Change in SCLC: Optimizing the Use of Standard Therapies and Ac...
 
Brief introduction to information ecosystem x public health.pptx
Brief introduction to information ecosystem x public health.pptxBrief introduction to information ecosystem x public health.pptx
Brief introduction to information ecosystem x public health.pptx
 
SGK BỆNH LÝ GOUT YHN hay lắm nha aaaa.pdf
SGK BỆNH LÝ GOUT YHN hay lắm nha aaaa.pdfSGK BỆNH LÝ GOUT YHN hay lắm nha aaaa.pdf
SGK BỆNH LÝ GOUT YHN hay lắm nha aaaa.pdf
 
airway management recorded for S2.pptx
airway management  recorded  for S2.pptxairway management  recorded  for S2.pptx
airway management recorded for S2.pptx
 
Thyroid function tests for MBBS, LAB. MED & BDS.pptx
Thyroid function tests for MBBS, LAB. MED & BDS.pptxThyroid function tests for MBBS, LAB. MED & BDS.pptx
Thyroid function tests for MBBS, LAB. MED & BDS.pptx
 
NECROSIS FOR MBBS FIRST YEAR STUDENTS MADE EASY.pptx
NECROSIS FOR MBBS FIRST YEAR STUDENTS MADE EASY.pptxNECROSIS FOR MBBS FIRST YEAR STUDENTS MADE EASY.pptx
NECROSIS FOR MBBS FIRST YEAR STUDENTS MADE EASY.pptx
 
Derma Pharmaceutical Franchise Company - Solace Biotech Limited
Derma Pharmaceutical Franchise Company - Solace Biotech LimitedDerma Pharmaceutical Franchise Company - Solace Biotech Limited
Derma Pharmaceutical Franchise Company - Solace Biotech Limited
 
TARGET DELINEATION IN CERVIX CANCER BY DR KANHU
TARGET DELINEATION IN CERVIX CANCER BY DR KANHUTARGET DELINEATION IN CERVIX CANCER BY DR KANHU
TARGET DELINEATION IN CERVIX CANCER BY DR KANHU
 
Ten lessons learnt as anesthetist.pptx
Ten  lessons  learnt as anesthetist.pptxTen  lessons  learnt as anesthetist.pptx
Ten lessons learnt as anesthetist.pptx
 
ANATOMY OF THE CEREBRUM WITH CLINICAL ANATOMY.pptx
ANATOMY OF THE CEREBRUM WITH CLINICAL ANATOMY.pptxANATOMY OF THE CEREBRUM WITH CLINICAL ANATOMY.pptx
ANATOMY OF THE CEREBRUM WITH CLINICAL ANATOMY.pptx
 
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
 
SGK VIÊM KHỚP DẠNG THẤP YHN .pdf
SGK VIÊM KHỚP DẠNG THẤP YHN              .pdfSGK VIÊM KHỚP DẠNG THẤP YHN              .pdf
SGK VIÊM KHỚP DẠNG THẤP YHN .pdf
 
INTRODUCTION TO THE FORENSIC SCIENCE.ppt
INTRODUCTION TO THE FORENSIC SCIENCE.pptINTRODUCTION TO THE FORENSIC SCIENCE.ppt
INTRODUCTION TO THE FORENSIC SCIENCE.ppt
 
Methicillin-resistant Staphylococcus Aureus (MRSA)
Methicillin-resistant Staphylococcus Aureus (MRSA)Methicillin-resistant Staphylococcus Aureus (MRSA)
Methicillin-resistant Staphylococcus Aureus (MRSA)
 
(IDE)and(IVD),QMS,21 CFR part820 , 801)
(IDE)and(IVD),QMS,21 CFR part820  , 801)(IDE)and(IVD),QMS,21 CFR part820  , 801)
(IDE)and(IVD),QMS,21 CFR part820 , 801)
 
Neurological Evaluation of Acute Ischemic stroke in Emergency Room
Neurological Evaluation of Acute Ischemic stroke in Emergency RoomNeurological Evaluation of Acute Ischemic stroke in Emergency Room
Neurological Evaluation of Acute Ischemic stroke in Emergency Room
 
bleeding disorders 1 Dr.Nannika Pradhan
bleeding disorders 1  Dr.Nannika Pradhanbleeding disorders 1  Dr.Nannika Pradhan
bleeding disorders 1 Dr.Nannika Pradhan
 
TARGET DELINEATION IN RECTUM CANCER BY DR KANHU
TARGET DELINEATION IN RECTUM  CANCER BY DR KANHUTARGET DELINEATION IN RECTUM  CANCER BY DR KANHU
TARGET DELINEATION IN RECTUM CANCER BY DR KANHU
 

Caroli syndrome

  • 1. Caroli disease Ahmed Abdulghany
  • 2. In 1958, Jacques Caroli first described a rare congenital condition in which there was a non-obstructive saccular dilatation of large intrahepatic bile ducts. Caroli Syndrome: more common variable in which bile duct dilatation is associated with congenital hepatic fibrosis
  • 3. Genetics Incompletely understood however gene for autosomal recessive polycystic kidney disease has been linked to caroli disease coding for Fibrocystin.
  • 4. Clinical manifestations There are several modes of presentations depending on the age of onset and predominance of hepatic or renal involvement. Biliary dilation predispose to biliary stagnation and stone formation. Bacterial cholangitis occur frequently and may be complicated by septicemia.
  • 5. Diagnosis Established by imaging studies (US & MRCP) showing irregular, cystic dilation of proximal intrahepatic bile ducts with normal common bile duct.
  • 6. Liver functions show mild cholestatic pattern Liver biopsy is rarely required for diagnosis
  • 7. Differential diagnosis 1ry biliary cirrhosis 1ry sclerosing cholangitis Drug induced cholestasis Intrahepatic cholestasis of pregnancy Sarcoidosis Amyloidosis Infiltrating neoplasms
  • 8. Treatment Supportive Complications as cholangitis and portal hypertension Liver transplantation for recurrent cholangitis
  • 9. Prognosis Variable depending upon severity of the disease and presence of coexisting renal dysfunction. Although risk of cholangiocarcinoma is up to 7%, surveillance is unclear. Suspect if there is unexplained clinical deterioration or development of new biliary strictures.

Editor's Notes

  1. CENTRAL DOT SIGN: small foci of strong contrast enhancement
  2. ----- Meeting Notes (10/26/14 22:00) ----- Supportive: cholangitis fat sol vitamens portal htn