Presentation at OneMedForum, San Francisco. January 2011

158 views

Published on

"At The Forefront of Stem Cell Therapy"

1/12/2011

Published in: Technology, Business
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
158
On SlideShare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
1
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Presentation at OneMedForum, San Francisco. January 2011

  1. 1. Advanced Cell TechnologyAt The Forefront ofStem Cell TherapyJanuary 2011 Corporate Presentation
  2. 2. This presentation is intended to present a summary of ACT’s (“ACT”, or “Advanced Cell TechnologyInc”, or “the Company”) salient business characteristics.The information herein contains “forward-looking statements” as defined under the federal securitieslaws. Actual results could vary materially. Factors that could cause actual results to vary materially aredescribed in our filings with the Securities and Exchange Commission.You should pay particular attention to the “risk factors” contained in documents we file from time to timewith the Securities and Exchange Commission. The risks identified therein, as well as others notidentified by the Company, could cause the Company’s actual results to differ materially from thoseexpressed in any forward-looking statements.Cautionary Statement Concerning Forward-Looking Statements2
  3. 3. At The Forefront of Regenerative Medicine3• Method of Producing human embryonic stem cells (hESCs)without Harm to Embryo• Commencing 2 of 3 Human Clinical Trials using hESCs EverApproved by FDA in coming months• Stargardt’s Disease• Dry AMD – (Dry Age-Related Macular Degeneration)• Myoblast Program for Heart Failure approved for Phase II• Seeking to File IND for our Hemangioblast Program
  4. 4. Blastomere Program• Method for generating hESCs without harm tothe embryo• Uses routine method similar to pre-implantationgenetic diagnostics (PGD)• PGD is routine - used in thousands ofpregnancies every year• Published in Nature and Cell Stem Cell• NIH proposing expanded funding toaccommodate ACT’s blastomere-derived lines.4
  5. 5. Therapeutic Programs Indication Clinical StageRetinal Pigment Epithelium (RPE)ProgramStargardt’s Macular DystrophyDry AMDIND approved Nov. 2010Phase I to begin 1st Half 2011IND approved Jan. 3, 2011Phase I to begin 1st Half 2011Myoblast Program Heart Disease, Heart Attack andHeart FailurePhase I successfully completedFDA-approved for Phase IIHemangioblast Program Diseases and Disorders of Circulatoryand Vascular SystemPreclinicalAnticipate IND filing 20115
  6. 6. RPE Program: Why the Eye? Why RPE Cells?• Eye is immune-privileged• RPE cells are pigmented so easy to identify(no need for staining)• Small dosage vs. other therapies6• Ease of administration– Doesn’t require separate approval by the FDA– Procedure already used by eye surgeons; no new skill set required for doctorsRPE cell therapy could positivelyimpact over 200 retinal diseases
  7. 7. Dry AMD– The most common form of Age-Related Macular Degeneration (as high as 90percent)– Affects 10-15 Million Americans– No Approved Therapies available– $25-30 Billion market in US and Europe alone– FDA-approved for Phase I/II clinical trial; will start first half 2011Stargardt’s Disease– Affects at least 30,000 Americans– FDA Orphan Status; 7 years of Market Exclusivity– FDA-approved for Phase I/II clinical trial; will start first half 2011– Applying for similar Orphan Status in EuropeDry AMD and Stargardt’s Disease Programs7
  8. 8. Myoblast ProgramAdult Stem Cells for Treatment of Heart FailureTarget MarketSufferers of Heart Failure, Chronic HeartFailure and patients with scarred orischemic (dead) heart tissue caused by orrelated to heart attackProgram StatusClearance from FDA to Proceed with PhaseII Clinical TrialCharlestown, MA GMP Facility8
  9. 9. Hemangioblast ProgramSynthesizing Blood CellsThe HG cell is the precursor to all cell types in the circulatory andvascular systems9
  10. 10. Hemangioblast Program• Investigating using HG cells to treatcardiovascular disease, stroke and cancer• Can generate large numbers, documentedin Nature Methods• Joint Venture with leading Korean stemcell developer CHA Biotech10
  11. 11. 11Intellectual PropertyRPE Cells• Worldwide Patent Filings• Dominant Patent Position for Treating Retinal Degeneration• One issued patent broadly covers methods for treating retinaldegeneration using human RPE cells differentiated from hESCs.• Broad IP Coverage for Manufacturing RPE Cells from hESCs• Two other patentsBlastomere Technology• Worldwide Patent Filings• Pending domestic patent applications
  12. 12. 12Solid Financial FootingMost Stable Financial Situation In Company History• 12/31 Announced $25 Million Funding Commitment• $15 Million on Balance Sheet• More Available• Virtually Debt-Free• Able to pay for both clinical trials, but that will likely notbe necessary:• Anticipate additional non-dilutive funding• Federal and state grants• Other grant and loan sources
  13. 13. The Advanced Cell Technology TeamWorld Class Scientific TeamSeasoned Management TeamDr. Robert Lanza, M.D. – Chief Scientific OfficerDr. Jonathan Dinsmore, Ph.D. – Myoblast Project AdvisorMatthew Vincent, Ph.D. – Business Development and IP Strategy13Gary Rabin – Interim CEOEdmund Mickunas – Vice President of RegulatoryRoger Gay, PhD – Senior Director of ManufacturingRita Parker – Director of OperationsBill Douglass – Director of Corporate Communications & Social MediaStephen Price – Interim SVP – Corporate Development
  14. 14. Thank you for your timeFor more information, visit www.advancedcell.com14

×