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8. digesti

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4 pharmacy n from pharmacy

4 pharmacy n from pharmacy

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  • 1. DIGESTIVE ENZYMES Oleh Slamet Priyanto
  • 2. DIGESTIVE ENZYMES ENZYME ? DIGESTI ? AKTIVITAS & TEMPAT
  • 3.  TEMPAT DIGESTIo MULUT• ENZIME- PTIALIN/ AMILASE SALIVA- AKTIVITAS:- Digesti amilum- pH opt : 6,8- Hilang pada pH 4,0- HASIL : Oligosakarida, glukosa
  • 4. o LAMBUNG• ENZIM: PEPSIN, RENNIN/ KIMOSIN, RENNET1. PEPSIN• AKTIVASI : HCl• PESINOGEN PEPSIN PEPSIN• AKTIVITAS :• Ikatan peptida antara :• AA aromatik / AA dikarboksilat• pH : 1,0 -2,0• HASIL : Pepton, proteosa
  • 5. 2. RENNIN• Hanya terdapat pada lambung bayi• AKTIVITAS : KOAGULASI KASEIN• REAKSI : RENNIN• KASEIN + Ca2+ PARAKASEIN PEPSIN• PARAKASEIN PEPTON3. LIPASE• SBG BUFFER
  • 6. o USUS HALUS SEKRET PANKREAS :• KONSTITUEN:• AIR, BAHAN ORG & ANORG• pH 7,5 - 8,0• ENZIM - ENZIM
  • 7.  ENZ – ENZ DIGESTIV USUS HALUSA. TRIPSIN & KIMOTRIPSIN• AKTIVASI : Enterokinase- TRIPSINOGEN TRIPSIN Tripsin- KIMOTRIPSINOGEN KIMOTRIPSIN• DAYA PROTEOLITIK : ENDOPEPTIDASE• AKTIVITAS• pH : 7,5 - 12,0• TRIPSIN : IKT PEPTIDA DLM MOL PROT• KIMOTRIPSIN: IKT PEPTIDA YG DIBENTUK OLEH AA. AROMATIK• REAKSI : TripsinPROT, PROTEOSA, PEPTON POLIPEPTIDA Kimotripsin + PEPTIDA
  • 8. B. KARBOKSIPEPTIDASE• EKTRASELULER• ENDOPEPTIDASE• REAKSI :• AA-AA--AA--------------AA KARBOKSIPEP PEPTIDA + N-Ter C-Ter AA bebasC. AMILASE• ALFA AMILASE• AKTIVITAS AMILASE AMILUM MALTOSA + MALTOTRIOSA + DEXTRIN + GLUKOSA
  • 9. D. LIPASE• AKTIVITAS :HIDROLISIS LEMAK GLISEROL + 3. As. BebasE. KOLESTERIL ESTER HIDROLASE• AKTIVITAS : KOLESTEROL ESTER KOLESTEROL + As. LEMAKF. RIBONUKLEASE & DEOKSI RIBONUKLEASE• AKTIVITAS HIDROLISIS RNA & DNA
  • 10.  SEKRET USUS• KELENJAR BRUNNER & LIEBERKUHN• KONSTITUEN :1. AMINO PEPTIDASE2. DIPEPTIDASE3. DISAKARIDASE4. ISOMALTASE (alfa. DEKSTRINASE)5. Beta GALKTOSIDASE/TAKTASE
  • 11.  SEKRET KANTONG EMPEDU• ASAM EMPEDU PRIMER• ASAM KOLAT :• ASAM TAUROKOLAT & As. GLIKOKOLAT• ASAM KENODEOKSIKOLAT• As. TAUROKENODEOKSIKOLAT & As. GLIKOKENODEOKSIKOLAT• ASAM EMPEDU SEKUNDER• ASAM DEOKSIKOLAT• ASAM LITOKOLAT