Your SlideShare is downloading. ×
Etiology of lymphadenopathy
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×

Saving this for later?

Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime - even offline.

Text the download link to your phone

Standard text messaging rates apply

Etiology of lymphadenopathy

2,642
views

Published on

for more presentations …

for more presentations
http://medicalpresentation.blogspot.in/

Published in: Health & Medicine

0 Comments
4 Likes
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
2,642
On Slideshare
0
From Embeds
0
Number of Embeds
3
Actions
Shares
0
Downloads
127
Comments
0
Likes
4
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. LYMPHADENOPATHY-ETIOLOGY
  • 2. Lymphadenopathy - pathophysiology Lymph node enlargement may occur via any of the following mechanisms:  Nodal cells may replicate in response to antigenic stimulation or malignant transformation (e.g., lymphoma).  Large number of reactive cells from outside node (e.g., neutrophils or metastatic cells) may enter node.  Foreign material may be deposited into node by lipid-laden histiocytes (e.g., lipid storage diseases).  Vascular engorgement and edema may occur secondary to local cytokine release.  Suppuration secondary to tissue necrosis (e.g., Mycobacterium tuberculosis)
  • 3. Clinically 2 types Generalised and Localised
  • 4. Generalized adenopathy has beendefined as  involvement of three or more noncontiguous lymph node areas.  generalized lymphadenopathy is frequently associated with nonmalignant disorders
  • 5. 1.Common infectious causes:Bacterial Group A streptococcus Mycobacteria: typical and atypical Anaerobic bacteria Diphtheria Brucellosis Actinomycetes Gram –ve enterios
  • 6. Common infectious causes:Viral  Epstein-Barr virus  Herpes simplex  Measles  Mumps  Coxsackie  Adenovirus  HIV  Rubella
  • 7. Common infectious causes:Fungal / *Parasitic  Aspergillosis  Candida  Cryptococcus  Histoplasmosis  Coccidioidomycosis  Sporotrichosis  Blastomycosis  Toxoplasmosis*
  • 8. 2.Immunologic diseases.a. Rheumatoid arthritisb. Juvenile rheumatoid arthritisc. Mixed connective tissue diseased. Systemic lupus erythematosuse. Dermatomyositisf. Sjögren’s syndromeg. Serum sickness
  • 9. h. Drug hypersensitivityi. Primary biliary cirrhosisj. Graft-versus-host diseasek. Silicone-associated
  • 10. a. Hematologic—Hodgkin’s disease, non- Hodgkin’s lymphomas, acute or chronic lymphocytic leukemia, hairy cell leukemia, malignant histiocytosis, b. Metastatic—from numerous primary sites
  • 11. 4. Lipid storage diseases—Gaucher’s, Niemann-Pick5. Endocrine diseases—hyperthyroidism
  • 12. 6. Other disordersa. Castleman’s disease (giant lymph nodehyperplasia)b. Sarcoidosisc. Dermatopathic lymphadenitisd.Histiocytic necrotizing lymphadenitise. Sinus histiocytosis with massive lymphadenopathyf. Mucocutaneous lymph node syndrome (Kawasaki’sdisease
  • 13. g. Familial Mediterranean feverh. Severe hypertriglyceridemiai. Vascular transformation ofsinuses j. Inflammatory pseudotumor oflymph node
  • 14. Few causes of large nodes Lymphangitis  Acute  Suppurative-staphylococci most common cause-mode is firm and tender, erythematous and swollen  Cat Scratch- most common cause, node lasting longer than 3 wks. Found in any nodes, large, red, tender Hodgkin- malignant nodes matted, firm, rubbery, asymmetry is the rule Non-Hodgkin-malignant-well defined and solid, nontender Lymphadenitis – node it’s self is infected- one node enlarged, red , warm, tender- no streaking
  • 15. Mimicking Lymphadenopathy: Branchial cleft cyst Cystic hygroma Thyroglossal duct cyst Epidermoid cyst Sternocleidomastoid tumor
  • 16. Mimicking Lymphadenopathy: Branchial cleft cyst Cystic hygroma Thyroglossal duct cyst Epidermoid cyst Sternocleidomastoid tumor
  • 17.  The causes of lymphadenopathy is broad. A patients medical history and review of systems is important in narrowing this differential. Upon examination, recognizing the pattern of lymph drainage aids in seeking an infectious focus.
  • 18. THANK YOU!!!!