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Protein protein interaction basic
 

Protein protein interaction basic

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this presentation include info for stater students and have basic knowledge of pro pro interaction

this presentation include info for stater students and have basic knowledge of pro pro interaction

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    Protein protein interaction basic Protein protein interaction basic Presentation Transcript

    •  Ayesha Aftab Malik Amber Malik
    •  Proteins are the workhorses that facilitate most biological processes in a cell.
    •  The majority of proteins interact with other proteins for proper function Publication of the human genome Development of the field of proteomics,
    • Two types Stable Transient Both types can be weak or strong
    •  Alter the kinetic properties of enzymes Allow for substrate channeling Create a new binding site Inactivate or destroy a protein Change the specificity of a protein for interaction with different proteins Serve a regulatory role
    • SlowTime consumingNot accurateDifficult to handleCostlyLack of equipments
    • Primary databasesInt actMintBindstringMeta databasesPINAAPIP
    •  STRING: known and predicted protein interactions. Interactions physical and functional associations The database currently covers 5214234 proteins from 1133 organisms.
    •  K VOTE to create seven different integrated networks by using values of k ranging from 1-7. modularity, similarity-based modularity, clustering score, enrichment.
    •  Proteins rarely act alone